(117 nodes) Regulation of cell-substrate adhesion network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107090471	Uncharacterized protein. (1690 aa)
	LOC107088303	LIM domain-containing protein. (335 aa)
	tbcd	Tubulin folding cofactor D. (1198 aa)
	LOC107087645	Rac family small GTPase 3b. (192 aa)
	LOC107092212	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (870 aa)
	LOC107081852	Uncharacterized protein. (318 aa)
	LOC107092660	Fibronectin 1a. (2499 aa)
	bcar1	BCAR1 scaffold protein, Cas family member. (978 aa)
	EGFLAM	EGF like, fibronectin type III and laminin G domains. (914 aa)
	LOC107103178	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (187 aa)
	ptpra	Receptor-type tyrosine-protein phosphatase alpha. (813 aa)
	arl2	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	lrrc45	Leucine rich repeat containing 45. (674 aa)
	LOC107087022	Si:dkey-32e6.6. (605 aa)
	LOC107098980	Ras and Rab interactor 2. (1020 aa)
	ECM2	Extracellular matrix protein 2. (766 aa)
	nedd9	Neural precursor cell expressed, developmentally down-regulated 9. (787 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (228 aa)
	ARHGAP6	Rho GTPase activating protein 6. (729 aa)
	ENSCVAP00000009246	Cas scaffold protein family member 4. (771 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (292 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (435 aa)
	rac2	Uncharacterized protein. (192 aa)
	LOC107090375	Uncharacterized protein. (271 aa)
	LOC107101297	Chondroitin sulfate proteoglycan 5b. (636 aa)
	LOC107098912	Ras responsive element binding protein 1a. (1793 aa)
	ILK	Integrin linked kinase. (452 aa)
	ajap1	Adherens junctions associated protein 1. (390 aa)
	FBLN2	Fibulin 2. (1170 aa)
	fermt1	Fermitin family member 1. (665 aa)
	LOC107084203	Vitronectin b. (439 aa)
	limch1	LIM and calponin homology domains 1b. (1096 aa)
	egfl6	EGF-like-domain, multiple 6. (539 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (379 aa)
	crk	CRK proto-oncogene, adaptor protein. (310 aa)
	tesk1	Si:dkeyp-75h12.2. (669 aa)
	LOC107101748	Uncharacterized protein. (281 aa)
	LOC107080763	Uncharacterized protein. (357 aa)
	LOC107083575	LIM domain-containing protein. (407 aa)
	LOC107084669	Neuron-derived neurotrophic factor, like. (601 aa)
	LOC107080667	Uncharacterized protein. (202 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (532 aa)
	cspg5	Chondroitin sulfate proteoglycan 5a. (602 aa)
	GREM1	Gremlin. (184 aa)
	LOC107084591	Vinculin a. (1066 aa)
	LOC107092536	Rac family small GTPase 1b. (192 aa)
	nexmif	Neurite extension and migration factor b. (1450 aa)
	LOC107088538	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1132 aa)
	ENSCVAP00000016658	BCAS3 microtubule associated cell migration factor. (344 aa)
	LOC107101058	Uncharacterized protein. (282 aa)
	cask	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (955 aa)
	LOC107087916	Uncharacterized protein. (437 aa)
	ENSCVAP00000017608	SCY domain-containing protein. (108 aa)
	ENSCVAP00000018010	MARVEL domain-containing protein. (173 aa)
	ap1ar	Adaptor related protein complex 1 associated regulatory protein. (282 aa)
	LOC107094679	Ephrin-A5a; Belongs to the ephrin family. (229 aa)
	LOC107092396	Olfactomedin-like domain-containing protein. (459 aa)
	LOC107083382	BCL2 apoptosis regulator b. (227 aa)
	ptk2b	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (995 aa)
	LOC107085000	Uncharacterized protein. (277 aa)
	ENSCVAP00000020878	Coiled-coil domain containing 80. (756 aa)
	ENSCVAP00000021138	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (400 aa)
	LOC107095682	Elastin microfibril interfacer 1a. (1022 aa)
	ENSCVAP00000021860	Uncharacterized protein. (80 aa)
	CDC42	Cell division cycle 42. (191 aa)
	Wdpcp	Uncharacterized protein. (96 aa)
	agr2	Anterior gradient 2. (166 aa)
	tsta3	Tissue specific transplantation antigen P35B. (325 aa)
	LOC107100889	Si:dkeyp-66d1.7. (294 aa)
	LOC107100883	MARVEL domain-containing protein. (296 aa)
	LOC107090045	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (550 aa)
	LOC107101988	Testis associated actin remodelling kinase 2. (597 aa)
	spry4	Sprouty homolog 4 (Drosophila). (381 aa)
	LOC107100882	Uncharacterized protein. (293 aa)
	LOC107090056	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	LOC107100840	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (346 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSCVAP00000023371	Uncharacterized protein. (456 aa)
	LOC107103176	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (183 aa)
	nf1	Neurofibromin 1b. (2729 aa)
	LOC107086129	Uncharacterized protein. (191 aa)
	vwc2	Von Willebrand factor C domain containing 2. (303 aa)
	ccn1	Cellular communication network factor 1. (375 aa)
	COL26A1	Collagen type XXVI alpha 1 chain. (429 aa)
	myoc	Myocilin. (480 aa)
	ENSCVAP00000002342	Uncharacterized protein. (534 aa)
	LOC107087152	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (492 aa)
	ENSCVAP00000001965	Protein kinase domain-containing protein. (113 aa)
	LOC107096201	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1105 aa)
	ENSCVAP00000001689	Uncharacterized protein. (284 aa)
	LOC107091163	Zgc:77748. (284 aa)
	LOC107091162	Uncharacterized protein. (284 aa)
	LOC107094621	Uncharacterized protein. (967 aa)
	ndnf	Neuron-derived neurotrophic factor. (571 aa)
	ENSCVAP00000000853	Elastin microfibril interfacer 1b. (871 aa)
	LOC107082256	Uncharacterized protein. (191 aa)
	dab2	DAB adaptor protein 2. (767 aa)
	LOC107092393	Si:ch211-173a9.6. (471 aa)
	vcl	Vinculin b. (1066 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1048 aa)
	LOC107084008	Epithelial cell adhesion molecule. (298 aa)
	LOC107085118	Uncharacterized protein. (191 aa)
	LOC107091872	Eph receptor A4b. (985 aa)
	ENSCVAP00000030809	Uncharacterized protein. (267 aa)
	LOC107090777	Junction plakoglobin a. (724 aa)
	LOC107087944	C-C motif chemokine. (95 aa)
	LOC107084047	Protein S100; Belongs to the S-100 family. (98 aa)
	LOC107102465	TSC complex subunit 1b. (1258 aa)
	ENSCVAP00000028612	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (150 aa)
	ENSCVAP00000028198	Integrin beta 1 binding protein 1. (142 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	LOC107102916	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	LOC107083630	Olfactomedin-like domain-containing protein. (459 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (308 aa)
	plekha2	Si:ch211-204d2.4. (282 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (277 aa)
	vtn	Vitronectin a. (543 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP6	CDC42	ENSCVAP00000009238	ENSCVAP00000021883	Rho GTPase activating protein 6.	Cell division cycle 42.	0.431
ARHGAP6	LOC107082256	ENSCVAP00000009238	ENSCVAP00000000232	Rho GTPase activating protein 6.	Uncharacterized protein.	0.407
ARHGAP6	LOC107085118	ENSCVAP00000009238	ENSCVAP00000031124	Rho GTPase activating protein 6.	Uncharacterized protein.	0.431
ARHGAP6	LOC107086129	ENSCVAP00000009238	ENSCVAP00000003772	Rho GTPase activating protein 6.	Uncharacterized protein.	0.407
ARHGAP6	LOC107087645	ENSCVAP00000009238	ENSCVAP00000024612	Rho GTPase activating protein 6.	Rac family small GTPase 3b.	0.414
ARHGAP6	LOC107092536	ENSCVAP00000009238	ENSCVAP00000016191	Rho GTPase activating protein 6.	Rac family small GTPase 1b.	0.414
ARHGAP6	egfl6	ENSCVAP00000009238	ENSCVAP00000011254	Rho GTPase activating protein 6.	EGF-like-domain, multiple 6.	0.465
ARHGAP6	rac2	ENSCVAP00000009238	ENSCVAP00000009517	Rho GTPase activating protein 6.	Uncharacterized protein.	0.414
CDC42	ARHGAP6	ENSCVAP00000021883	ENSCVAP00000009238	Cell division cycle 42.	Rho GTPase activating protein 6.	0.431
CDC42	LOC107087645	ENSCVAP00000021883	ENSCVAP00000024612	Cell division cycle 42.	Rac family small GTPase 3b.	0.625
CDC42	LOC107088538	ENSCVAP00000021883	ENSCVAP00000016429	Cell division cycle 42.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.486
CDC42	LOC107092212	ENSCVAP00000021883	ENSCVAP00000024482	Cell division cycle 42.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.486
CDC42	LOC107092536	ENSCVAP00000021883	ENSCVAP00000016191	Cell division cycle 42.	Rac family small GTPase 1b.	0.625
CDC42	LOC107096201	ENSCVAP00000021883	ENSCVAP00000001959	Cell division cycle 42.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.486
CDC42	ptk2b	ENSCVAP00000021883	ENSCVAP00000019590	Cell division cycle 42.	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.486
CDC42	rac2	ENSCVAP00000021883	ENSCVAP00000009517	Cell division cycle 42.	Uncharacterized protein.	0.625
CDC42	rasa1	ENSCVAP00000021883	ENSCVAP00000032034	Cell division cycle 42.	RAS p21 protein activator (GTPase activating protein) 1a.	0.547
EFNA5	LOC107091872	ENSCVAP00000009072	ENSCVAP00000030994	Ephrin A5; Belongs to the ephrin family.	Eph receptor A4b.	0.539
ENSCVAP00000001965	ENSCVAP00000021138	ENSCVAP00000001965	ENSCVAP00000021138	Protein kinase domain-containing protein.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.874
ENSCVAP00000001965	cask	ENSCVAP00000001965	ENSCVAP00000017370	Protein kinase domain-containing protein.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.736