(46 nodes) Positive regulation of macroautophagy network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCVAP00000004363	WW domain-containing protein. (198 aa)
	sirt1	Sirtuin 1. (691 aa)
	LOC107083298	Sestrin 2. (553 aa)
	pip4k2a	Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a. (443 aa)
	pink1	PTEN induced kinase 1. (472 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (412 aa)
	lrsam1	Leucine rich repeat and sterile alpha motif containing 1. (482 aa)
	htt	Huntingtin. (2595 aa)
	LOC107094864	Forkhead box A3. (468 aa)
	sptlc1	Serine palmitoyltransferase, long chain base subunit 1. (440 aa)
	snx30	Sorting nexin family member 30. (444 aa)
	ENSCVAP00000014329	PX domain-containing protein. (127 aa)
	c9orf72	Zgc:100846. (462 aa)
	gpsm1	G protein signaling modulator 1b. (658 aa)
	LOC107092565	Si:zfos-80g12.1. (444 aa)
	wdr45	WD repeat domain 45. (296 aa)
	snx4	Sorting nexin 4. (438 aa)
	LOC107101625	PX domain-containing protein. (432 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (921 aa)
	scoc	Short coiled-coil protein a. (80 aa)
	tsc2	TSC complex subunit 2. (1708 aa)
	ENSCVAP00000021578	Uncharacterized protein. (662 aa)
	hspb8	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family. (221 aa)
	rnf31	Ring finger protein 31. (1112 aa)
	ENSCVAP00000023371	Uncharacterized protein. (456 aa)
	rab3gap2	RAB3 GTPase activating protein subunit 2 (non-catalytic). (1208 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (320 aa)
	dcn	Decorin; May affect the rate of fibrils formation. (359 aa)
	calcoco2	SKICH domain-containing protein. (592 aa)
	ENSCVAP00000026994	Uncharacterized protein. (472 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1374 aa)
	ENSCVAP00000029384	Decorin; May affect the rate of fibrils formation. (102 aa)
	LOC107102465	TSC complex subunit 1b. (1258 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (460 aa)
	sting1	Transmembrane protein 173. (395 aa)
	LOC107096175	Uncharacterized protein. (320 aa)
	bnip3	BCL2 interacting protein 3. (191 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (986 aa)
	LOC107099770	Uncharacterized protein. (1053 aa)
	vps13d	Vacuolar protein sorting 13 homolog D. (4296 aa)
	LOC107088947	Zgc:73226. (182 aa)
	LOC107081664	FYVE and coiled-coil domain containing 1b. (1385 aa)
	wdr24	WD repeat domain 24. (787 aa)
	sesn1	Sestrin 1. (548 aa)
	LOC107081974	FYVE and coiled-coil domain containing 1a. (1456 aa)
	LOC107096835	Uncharacterized protein. (749 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000004363	hspb8	ENSCVAP00000004363	ENSCVAP00000021692	WW domain-containing protein.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.898
ENSCVAP00000014329	LOC107101625	ENSCVAP00000014329	ENSCVAP00000018098	PX domain-containing protein.	PX domain-containing protein.	0.815
ENSCVAP00000014329	snx4	ENSCVAP00000014329	ENSCVAP00000016655	PX domain-containing protein.	Sorting nexin 4.	0.815
ENSCVAP00000021578	RIPK2	ENSCVAP00000021578	ENSCVAP00000030122	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.831
ENSCVAP00000023371	hspb8	ENSCVAP00000023371	ENSCVAP00000021692	Uncharacterized protein.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.422
ENSCVAP00000023371	pink1	ENSCVAP00000023371	ENSCVAP00000006233	Uncharacterized protein.	PTEN induced kinase 1.	0.487
ENSCVAP00000023371	tsc2	ENSCVAP00000023371	ENSCVAP00000020496	Uncharacterized protein.	TSC complex subunit 2.	0.975
LOC107083298	LOC107092565	ENSCVAP00000005555	ENSCVAP00000015684	Sestrin 2.	Si:zfos-80g12.1.	0.904
LOC107083298	sesn1	ENSCVAP00000005555	ENSCVAP00000000738	Sestrin 2.	Sestrin 1.	0.903
LOC107083298	tsc2	ENSCVAP00000005555	ENSCVAP00000020496	Sestrin 2.	TSC complex subunit 2.	0.412
LOC107083298	wdr24	ENSCVAP00000005555	ENSCVAP00000000857	Sestrin 2.	WD repeat domain 24.	0.978
LOC107088947	pink1	ENSCVAP00000032705	ENSCVAP00000006233	Zgc:73226.	PTEN induced kinase 1.	0.443
LOC107092565	LOC107083298	ENSCVAP00000015684	ENSCVAP00000005555	Si:zfos-80g12.1.	Sestrin 2.	0.904
LOC107092565	sesn1	ENSCVAP00000015684	ENSCVAP00000000738	Si:zfos-80g12.1.	Sestrin 1.	0.904
LOC107092565	wdr24	ENSCVAP00000015684	ENSCVAP00000000857	Si:zfos-80g12.1.	WD repeat domain 24.	0.755
LOC107096835	RIPK2	ENSCVAP00000004099	ENSCVAP00000030122	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.831
LOC107101625	ENSCVAP00000014329	ENSCVAP00000018098	ENSCVAP00000014329	PX domain-containing protein.	PX domain-containing protein.	0.815
LOC107101625	snx30	ENSCVAP00000018098	ENSCVAP00000012553	PX domain-containing protein.	Sorting nexin family member 30.	0.815
LOC107101625	snx4	ENSCVAP00000018098	ENSCVAP00000016655	PX domain-containing protein.	Sorting nexin 4.	0.901
LOC107102465	hspb8	ENSCVAP00000029404	ENSCVAP00000021692	TSC complex subunit 1b.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.422