(88 nodes) Protein kinase activator activity network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STRADB	STE20 related adaptor beta. (430 aa)
	DGKQ	Diacylglycerol kinase. (917 aa)
	ccny	Cyclin Y; Belongs to the cyclin family. (287 aa)
	parp16	Poly [ADP-ribose] polymerase. (301 aa)
	LOC107089263	CD40 ligand; Belongs to the tumor necrosis factor family. (240 aa)
	gas6	Uncharacterized protein. (652 aa)
	bmpr1a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (522 aa)
	LOC107101915	Transforming growth factor, alpha. (242 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	ccnt1	Cyclin T1; Belongs to the cyclin family. (668 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1052 aa)
	LOC107084224	Cyclin Y like 1; Belongs to the cyclin family. (341 aa)
	ccnk	Cyclin K; Belongs to the cyclin family. (543 aa)
	armc9	Armadillo repeat containing 9. (843 aa)
	ereg	EGF-like domain-containing protein. (151 aa)
	LOC107085304	EGF-like domain-containing protein. (165 aa)
	incenp	Uncharacterized protein. (849 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC107089813	Neuregulin 2a. (673 aa)
	LOC107086019	Heparin-binding EGF-like growth factor a. (237 aa)
	Als2	Uncharacterized protein. (629 aa)
	pak2	Non-specific serine/threonine protein kinase. (528 aa)
	LOC107083525	Uncharacterized protein. (1486 aa)
	GPRC5D	G protein-coupled receptor class C group 5 member D. (417 aa)
	ENSCVAP00000014019	SH3 domain-containing protein. (102 aa)
	dusp19	Dual specificity phosphatase 19a. (211 aa)
	gprc5c	G protein-coupled receptor, class C, group 5, member C. (414 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Bb. (419 aa)
	LOC107084040	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (77 aa)
	ccnyl1	Cyclin Y-like 1; Belongs to the cyclin family. (346 aa)
	GREM1	Gremlin. (184 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1002 aa)
	LOC107082390	Calcium binding protein 39, like 1. (343 aa)
	LOC107097541	Uncharacterized protein. (143 aa)
	LOC107096388	EGF-like domain-containing protein. (625 aa)
	LOC107100795	ALK and LTK ligand 1. (157 aa)
	fam20a	FAM20A golgi associated secretory pathway pseudokinase. (536 aa)
	LOC107086848	Abl-interactor 1b. (529 aa)
	LOC107105186	Cyclin-dependent kinase 5 activator. (324 aa)
	tpx2	TPX2 microtubule nucleation factor. (707 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (260 aa)
	ccnt2	Cyclin T2; Belongs to the cyclin family. (695 aa)
	LOC107103972	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (739 aa)
	ENSCVAP00000019147	WD_REPEATS_REGION domain-containing protein. (66 aa)
	LOC107100960	Calcium binding protein 39-like. (334 aa)
	LOC107087288	MOB kinase activator 1A. (216 aa)
	LOC107096926	Uncharacterized protein. (558 aa)
	LOC107093367	MOB kinase activator 1Bb. (216 aa)
	LOC107104991	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (555 aa)
	LOC107089487	Insulin-like growth factor 2b. (214 aa)
	rplp1	Ribosomal protein, large, P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (112 aa)
	mob3c	MOB kinase activator 3C. (216 aa)
	btc	EGF-like domain-containing protein. (176 aa)
	bmpr1b	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	LOC107104706	Uncharacterized protein. (561 aa)
	LOC107097720	MOB kinase activator 3A. (216 aa)
	cab39	Calcium binding protein 39. (341 aa)
	strada	STE20 related adaptor alpha. (428 aa)
	dele1	Uncharacterized protein. (503 aa)
	LOC107101840	Cyclin-dependent kinase 5 activator. (331 aa)
	LOC107083164	G_PROTEIN_RECEP_F3_4 domain-containing protein. (398 aa)
	ENSCVAP00000027183	annotation not available (180 aa)
	LOC107090307	Sprouty RTK signaling antagonist 2. (351 aa)
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	LOC107092537	G protein-coupled receptor, class C, group 5, member Ba. (397 aa)
	LOC107085705	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	LOC107090144	Neuregulin 2b. (696 aa)
	LOC107085681	Uncharacterized protein. (380 aa)
	LOC107088457	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
	ENSCVAP00000031960	CYCLIN domain-containing protein; Belongs to the cyclin family. (220 aa)
	ENSCVAP00000032923	Uncharacterized protein. (71 aa)
	ENSCVAP00000032381	WD_REPEATS_REGION domain-containing protein. (68 aa)
	daxx	Death-domain associated protein. (673 aa)
	dbf4	DBF4 zinc finger. (606 aa)
	LOC107096283	Dual specificity phosphatase 19b. (203 aa)
	LOC107105022	Regulator of cell cycle. (126 aa)
	LOC107087175	Fam20C domain-containing protein. (425 aa)
	LOC107099756	DBF4-type domain-containing protein. (786 aa)
	ercc6	Excision repair cross-complementation group 6. (1441 aa)
	LOC107090555	Si:dkey-266m15.5. (241 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1724 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (449 aa)
	cdk5r1	Cyclin-dependent kinase 5 activator. (307 aa)
	CCNY	CYCLIN domain-containing protein; Belongs to the cyclin family. (337 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1373 aa)
	Cdk5r2	Cyclin-dependent kinase 5, regulatory subunit 2b (p39). (296 aa)
	alkal2	Uncharacterized protein. (157 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000019147	rictor	ENSCVAP00000019147	ENSCVAP00000003274	WD_REPEATS_REGION domain-containing protein.	RPTOR independent companion of MTOR, complex 2 a.	0.964
ENSCVAP00000019147	rptor	ENSCVAP00000019147	ENSCVAP00000005829	WD_REPEATS_REGION domain-containing protein.	Regulatory associated protein of MTOR, complex 1.	0.965
ENSCVAP00000031960	ccnk	ENSCVAP00000031960	ENSCVAP00000010311	CYCLIN domain-containing protein; Belongs to the cyclin family.	Cyclin K; Belongs to the cyclin family.	0.655
ENSCVAP00000031960	mnat1	ENSCVAP00000031960	ENSCVAP00000006112	CYCLIN domain-containing protein; Belongs to the cyclin family.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.619
ENSCVAP00000032381	rictor	ENSCVAP00000032381	ENSCVAP00000003274	WD_REPEATS_REGION domain-containing protein.	RPTOR independent companion of MTOR, complex 2 a.	0.964
ENSCVAP00000032381	rptor	ENSCVAP00000032381	ENSCVAP00000005829	WD_REPEATS_REGION domain-containing protein.	Regulatory associated protein of MTOR, complex 1.	0.965
LOC107082390	LOC107100960	ENSCVAP00000016206	ENSCVAP00000019289	Calcium binding protein 39, like 1.	Calcium binding protein 39-like.	0.901
LOC107082390	STRADB	ENSCVAP00000016206	ENSCVAP00000006286	Calcium binding protein 39, like 1.	STE20 related adaptor beta.	0.946
LOC107082390	cab39	ENSCVAP00000016206	ENSCVAP00000025864	Calcium binding protein 39, like 1.	Calcium binding protein 39.	0.901
LOC107082390	stk11	ENSCVAP00000016206	ENSCVAP00000003596	Calcium binding protein 39, like 1.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.975
LOC107082390	strada	ENSCVAP00000016206	ENSCVAP00000026050	Calcium binding protein 39, like 1.	STE20 related adaptor alpha.	0.946
LOC107085304	LOC107086019	ENSCVAP00000010557	ENSCVAP00000011715	EGF-like domain-containing protein.	Heparin-binding EGF-like growth factor a.	0.762
LOC107085304	LOC107101915	ENSCVAP00000010557	ENSCVAP00000008153	EGF-like domain-containing protein.	Transforming growth factor, alpha.	0.752
LOC107085304	btc	ENSCVAP00000010557	ENSCVAP00000022160	EGF-like domain-containing protein.	EGF-like domain-containing protein.	0.822
LOC107085304	ereg	ENSCVAP00000010557	ENSCVAP00000010550	EGF-like domain-containing protein.	EGF-like domain-containing protein.	0.797
LOC107085705	dbf4	ENSCVAP00000030517	ENSCVAP00000000810	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	DBF4 zinc finger.	0.516
LOC107086019	LOC107085304	ENSCVAP00000011715	ENSCVAP00000010557	Heparin-binding EGF-like growth factor a.	EGF-like domain-containing protein.	0.762
LOC107086019	LOC107090307	ENSCVAP00000011715	ENSCVAP00000028033	Heparin-binding EGF-like growth factor a.	Sprouty RTK signaling antagonist 2.	0.520
LOC107086019	LOC107101915	ENSCVAP00000011715	ENSCVAP00000008153	Heparin-binding EGF-like growth factor a.	Transforming growth factor, alpha.	0.766
LOC107086019	btc	ENSCVAP00000011715	ENSCVAP00000022160	Heparin-binding EGF-like growth factor a.	EGF-like domain-containing protein.	0.806