(86 nodes) Positive regulation of cell growth network (Cyprinodon variegatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	adnp2	ADNP homeobox 2b. (1004 aa)
	Fgfr1op	LisH domain-containing protein. (174 aa)
	LOC107101621	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC107084551	Uncharacterized protein. (807 aa)
	ino80	INO80 complex ATPase subunit. (1564 aa)
	RND2	Rho family GTPase 2. (230 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (410 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	dbnl	Drebrin-like b. (477 aa)
	LOC107084890	Si:ch211-113g11.6; Belongs to the semaphorin family. (641 aa)
	ucn	Urotensin 1. (144 aa)
	syt1	Synaptotagmin Ia. (422 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	ENSCVAP00000028604	Uncharacterized protein. (237 aa)
	spast	Spastin; Belongs to the AAA ATPase family. (474 aa)
	islr2	Immunoglobulin superfamily containing leucine-rich repeat 2. (716 aa)
	adam10	Uncharacterized protein. (752 aa)
	parp2	Poly [ADP-ribose] polymerase. (615 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
	ENSCVAP00000002342	Uncharacterized protein. (534 aa)
	slc44a4	Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (716 aa)
	extl3	Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (914 aa)
	LOC107095772	Protein kinase domain-containing protein. (1007 aa)
	LOC107102657	Uncharacterized protein. (143 aa)
	LOC107102666	NMDA receptor synaptonuclear signaling and neuronal migration factor b. (581 aa)
	LOC107097210	Synaptotagmin Vb. (424 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	shtn1	Shootin 1. (355 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1373 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	LOC107103127	Uncharacterized protein. (492 aa)
	Park2	RBR-type E3 ubiquitin transferase. (71 aa)
	ENSCVAP00000007456	Uncharacterized protein. (158 aa)
	LOC107087023	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (287 aa)
	golga4	Golgin A4. (2107 aa)
	supv3l1	SUV3-like helicase. (779 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1029 aa)
	ddx49	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family. (474 aa)
	LOC107103646	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
	LOC107087577	ADAM metallopeptidase domain 17a. (871 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1052 aa)
	ENSCVAP00000009967	Uncharacterized protein. (586 aa)
	LOC107097602	Parvalbumin 8; Belongs to the parvalbumin family. (109 aa)
	klhl22	Kelch-like family member 22. (634 aa)
	LOC107089162	Uncharacterized protein. (431 aa)
	ENSCVAP00000012808	Semaphorin 7A; Belongs to the semaphorin family. (443 aa)
	n6amt1	N-6 adenine-specific DNA methyltransferase 1. (226 aa)
	plaa	Phospholipase A2-activating protein. (798 aa)
	ist1	IST1 factor associated with ESCRT-III. (352 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	FXN	Uncharacterized protein. (187 aa)
	zfyve27	Zinc finger, FYVE domain containing 27. (420 aa)
	LOC107091926	Uncharacterized protein. (339 aa)
	LOC107080667	Uncharacterized protein. (202 aa)
	srf	MADS-box domain-containing protein. (596 aa)
	trim32	Tripartite motif containing 32. (679 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1354 aa)
	dbn1	Drebrin 1. (507 aa)
	LOC107102147	Cyclin-dependent kinase-like 5. (1054 aa)
	LOC107090732	Uncharacterized protein. (1208 aa)
	LOC107090161	COMM domain containing 5. (211 aa)
	adam17	ADAM metallopeptidase domain 17b. (844 aa)
	LOC107103972	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (739 aa)
	rnf157	Ring finger protein 157. (698 aa)
	exosc2	Exosome component 2. (293 aa)
	l1cam	L1 cell adhesion molecule, paralog a. (1279 aa)
	lgi1	Leucine-rich, glioma inactivated 1b. (492 aa)
	rusc1	Uncharacterized protein. (1858 aa)
	LOC107083382	BCL2 apoptosis regulator b. (227 aa)
	LOC107099889	NMDA receptor synaptonuclear signaling and neuronal migration factor a. (469 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2406 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (756 aa)
	cdkn2aip	CDKN2A interacting protein. (312 aa)
	nol12	Nucleolar protein 12. (231 aa)
	rufy3	RUN and FYVE domain containing 3. (637 aa)
	LOC107083863	Ig-like domain-containing protein. (693 aa)
	LOC107093197	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	exosc4	Exosome component 4. (245 aa)
	LOC107082632	MADS-box domain-containing protein. (489 aa)
	LOC107092660	Fibronectin 1a. (2499 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (415 aa)
	ENSCVAP00000025901	Uncharacterized protein. (112 aa)
	LOC107084753	Rho family GTPase 2. (235 aa)
	LOC107093683	Leucine-rich, glioma inactivated 1a. (545 aa)
	LOC107101223	Synaptotagmin-1-like. (424 aa)
	LOC107083922	Synaptotagmin IIa. (431 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000007456	mul1	ENSCVAP00000007456	ENSCVAP00000006273	Uncharacterized protein.	Mitochondrial E3 ubiquitin protein ligase 1b.	0.679
ENSCVAP00000025901	syt1	ENSCVAP00000025901	ENSCVAP00000028922	Uncharacterized protein.	Synaptotagmin Ia.	0.485
LOC107080667	LOC107083382	ENSCVAP00000015020	ENSCVAP00000019531	Uncharacterized protein.	BCL2 apoptosis regulator b.	0.900
LOC107082632	srf	ENSCVAP00000023494	ENSCVAP00000015112	MADS-box domain-containing protein.	MADS-box domain-containing protein.	0.902
LOC107083382	LOC107080667	ENSCVAP00000019531	ENSCVAP00000015020	BCL2 apoptosis regulator b.	Uncharacterized protein.	0.900
LOC107084753	golga4	ENSCVAP00000026629	ENSCVAP00000007730	Rho family GTPase 2.	Golgin A4.	0.493
LOC107087023	LOC107102657	ENSCVAP00000007664	ENSCVAP00000000652	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	Uncharacterized protein.	0.402
LOC107087023	igf1	ENSCVAP00000007664	ENSCVAP00000028775	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	Insulin-like growth factor 1.	0.564
LOC107087577	adam17	ENSCVAP00000009251	ENSCVAP00000018716	ADAM metallopeptidase domain 17a.	ADAM metallopeptidase domain 17b.	0.902
LOC107090161	mul1	ENSCVAP00000018315	ENSCVAP00000006273	COMM domain containing 5.	Mitochondrial E3 ubiquitin protein ligase 1b.	0.522
LOC107090732	l1cam	ENSCVAP00000032515	ENSCVAP00000019118	Uncharacterized protein.	L1 cell adhesion molecule, paralog a.	0.903
LOC107091926	LOC107093197	ENSCVAP00000014972	ENSCVAP00000023025	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.821
LOC107091926	LOC107101621	ENSCVAP00000014972	ENSCVAP00000031965	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.821
LOC107091926	sfrp2	ENSCVAP00000014972	ENSCVAP00000013859	Uncharacterized protein.	Secreted frizzled-related protein 2.	0.900
LOC107093197	LOC107091926	ENSCVAP00000023025	ENSCVAP00000014972	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.821
LOC107093197	sfrp2	ENSCVAP00000023025	ENSCVAP00000013859	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2.	0.821
LOC107101621	LOC107091926	ENSCVAP00000031965	ENSCVAP00000014972	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.821
LOC107101621	sfrp2	ENSCVAP00000031965	ENSCVAP00000013859	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2.	0.821
LOC107102657	LOC107087023	ENSCVAP00000000652	ENSCVAP00000007664	Uncharacterized protein.	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	0.402
LOC107102657	f2	ENSCVAP00000000652	ENSCVAP00000003097	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.662