(12 nodes) Beta-catenin destruction complex network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107090180	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (438 aa)
	apc	APC regulator of WNT signaling pathway. (1981 aa)
	AXIN2	Axin 2. (777 aa)
	cacybp	Calcyclin binding protein. (227 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	ENSCVAP00000032385	APC_N_CC domain-containing protein. (285 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	axin1	Axin 1. (845 aa)
	LOC107092835	Axin 2 (conductin, axil). (832 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2518 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (425 aa)
	LOC107097051	Uncharacterized protein. (883 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	ENSCVAP00000032385	ENSCVAP00000020009	ENSCVAP00000032385	Axin 2.	APC_N_CC domain-containing protein.	0.780
AXIN2	LOC107090180	ENSCVAP00000020009	ENSCVAP00000017264	Axin 2.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.792
AXIN2	apc	ENSCVAP00000020009	ENSCVAP00000019069	Axin 2.	APC regulator of WNT signaling pathway.	0.977
AXIN2	apc2	ENSCVAP00000020009	ENSCVAP00000010438	Axin 2.	APC regulator of WNT signaling pathway 2.	0.977
AXIN2	gsk3a	ENSCVAP00000020009	ENSCVAP00000028209	Axin 2.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.792
AXIN2	gsk3b	ENSCVAP00000020009	ENSCVAP00000011710	Axin 2.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.982
ENSCVAP00000032385	AXIN2	ENSCVAP00000032385	ENSCVAP00000020009	APC_N_CC domain-containing protein.	Axin 2.	0.780
ENSCVAP00000032385	LOC107090180	ENSCVAP00000032385	ENSCVAP00000017264	APC_N_CC domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.782
ENSCVAP00000032385	LOC107092835	ENSCVAP00000032385	ENSCVAP00000001964	APC_N_CC domain-containing protein.	Axin 2 (conductin, axil).	0.780
ENSCVAP00000032385	LOC107097051	ENSCVAP00000032385	ENSCVAP00000012572	APC_N_CC domain-containing protein.	Uncharacterized protein.	0.782
ENSCVAP00000032385	apc	ENSCVAP00000032385	ENSCVAP00000019069	APC_N_CC domain-containing protein.	APC regulator of WNT signaling pathway.	0.866
ENSCVAP00000032385	axin1	ENSCVAP00000032385	ENSCVAP00000021222	APC_N_CC domain-containing protein.	Axin 1.	0.782
ENSCVAP00000032385	ctnnbip1	ENSCVAP00000032385	ENSCVAP00000029424	APC_N_CC domain-containing protein.	Catenin, beta interacting protein 1.	0.575
ENSCVAP00000032385	gsk3a	ENSCVAP00000032385	ENSCVAP00000028209	APC_N_CC domain-containing protein.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.782
ENSCVAP00000032385	gsk3b	ENSCVAP00000032385	ENSCVAP00000011710	APC_N_CC domain-containing protein.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.782
LOC107090180	AXIN2	ENSCVAP00000017264	ENSCVAP00000020009	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Axin 2.	0.792
LOC107090180	ENSCVAP00000032385	ENSCVAP00000017264	ENSCVAP00000032385	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC_N_CC domain-containing protein.	0.782
LOC107090180	LOC107092835	ENSCVAP00000017264	ENSCVAP00000001964	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Axin 2 (conductin, axil).	0.792
LOC107090180	LOC107097051	ENSCVAP00000017264	ENSCVAP00000012572	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.809
LOC107090180	apc	ENSCVAP00000017264	ENSCVAP00000019069	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC regulator of WNT signaling pathway.	0.782