(52 nodes) Regulation of telomere maintenance network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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Your Input:
	Pot1	Telo_bind domain-containing protein. (332 aa)
	tinf2	TERF1 (TRF1)-interacting nuclear factor 2. (561 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1579 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1274 aa)
	ino80e	INO80 complex subunit E. (247 aa)
	ten1	TEN1 subunit of CST complex. (139 aa)
	ylpm1	YLP motif containing 1. (1733 aa)
	cct3	T-complex protein 1 subunit gamma. (540 aa)
	naf1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (300 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (386 aa)
	ino80	INO80 complex ATPase subunit. (1564 aa)
	smg5	SMG5 nonsense mediated mRNA decay factor. (949 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2502 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (623 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (570 aa)
	mcrs1	Microspherule protein 1. (430 aa)
	ino80d	INO80 complex subunit Da. (994 aa)
	nek2	NIMA-related kinase 2. (445 aa)
	ppp1r10	Protein phosphatase 1, regulatory subunit 10. (799 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1071 aa)
	sirt6	Sirtuin 6. (349 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)
	LOC107103120	SLX1 homolog B, structure-specific endonuclease subunit. (218 aa)
	dkc1	Dyskeratosis congenita 1, dyskerin. (511 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (416 aa)
	fbxo4	F-box protein 4. (392 aa)
	ENSCVAP00000009967	Uncharacterized protein. (586 aa)
	Terf2	Uncharacterized protein. (95 aa)
	smg6	SMG6 nonsense mediated mRNA decay factor. (1625 aa)
	ENSCVAP00000010843	Uncharacterized protein. (67 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1278 aa)
	ENSCVAP00000011755	TAN domain-containing protein. (119 aa)
	Atm	Uncharacterized protein. (145 aa)
	LOC107093706	Uncharacterized protein. (421 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (600 aa)
	exosc10	Exosome component 10. (888 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	LOC107084655	Poly [ADP-ribose] polymerase. (1261 aa)
	atrx	ATRX chromatin remodeler. (1892 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
	ercc1	Excision repair cross-complementation group 1. (351 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (533 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1170 aa)
	ENSCVAP00000018664	Uncharacterized protein. (129 aa)
	Nat10	DUF1726 domain-containing protein. (282 aa)
	Smg1	FATC domain-containing protein. (275 aa)
	Slx4	BTB domain-containing protein. (1002 aa)
	ENSCVAP00000021922	Uncharacterized protein. (698 aa)
	ccdc174	Coiled-coil domain containing 174. (540 aa)
	ercc4	Excision repair cross-complementation group 4. (885 aa)
	tfpt	Uncharacterized protein. (198 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSCVAP00000011755	ENSCVAP00000011758	ENSCVAP00000011755	Uncharacterized protein.	TAN domain-containing protein.	0.922
Atm	ENSCVAP00000018664	ENSCVAP00000011758	ENSCVAP00000018664	Uncharacterized protein.	Uncharacterized protein.	0.420
Atm	ENSCVAP00000021922	ENSCVAP00000011758	ENSCVAP00000021922	Uncharacterized protein.	Uncharacterized protein.	0.578
Atm	LOC107103120	ENSCVAP00000011758	ENSCVAP00000006986	Uncharacterized protein.	SLX1 homolog B, structure-specific endonuclease subunit.	0.633
Atm	Slx4	ENSCVAP00000011758	ENSCVAP00000018954	Uncharacterized protein.	BTB domain-containing protein.	0.612
Atm	Smg1	ENSCVAP00000011758	ENSCVAP00000021912	Uncharacterized protein.	FATC domain-containing protein.	0.578
Atm	atr	ENSCVAP00000011758	ENSCVAP00000030889	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.972
Atm	atrx	ENSCVAP00000011758	ENSCVAP00000016016	Uncharacterized protein.	ATRX chromatin remodeler.	0.420
Atm	ercc1	ENSCVAP00000011758	ENSCVAP00000016561	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.587
Atm	ercc4	ENSCVAP00000011758	ENSCVAP00000023074	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.622
Atm	rad50	ENSCVAP00000011758	ENSCVAP00000027755	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.994
Atm	rtel1	ENSCVAP00000011758	ENSCVAP00000017597	Uncharacterized protein.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.621
Atm	uchl5	ENSCVAP00000011758	ENSCVAP00000014031	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.408
Atm	xrcc1	ENSCVAP00000011758	ENSCVAP00000028501	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.404
Atm	xrcc5	ENSCVAP00000011758	ENSCVAP00000016035	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.879
ENSCVAP00000009967	ercc4	ENSCVAP00000009967	ENSCVAP00000023074	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.431
ENSCVAP00000009967	ino80d	ENSCVAP00000009967	ENSCVAP00000001684	Uncharacterized protein.	INO80 complex subunit Da.	0.824
ENSCVAP00000009967	ino80e	ENSCVAP00000009967	ENSCVAP00000019100	Uncharacterized protein.	INO80 complex subunit E.	0.947
ENSCVAP00000009967	mcrs1	ENSCVAP00000009967	ENSCVAP00000000832	Uncharacterized protein.	Microspherule protein 1.	0.823
ENSCVAP00000009967	nfrkb	ENSCVAP00000009967	ENSCVAP00000011693	Uncharacterized protein.	Nuclear factor related to kappaB binding protein.	0.908