(12 nodes) Histone H3-K9 demethylation network (Cyprinodon variegatus)

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Your Input:
	LOC107093321	Lysine (K)-specific demethylase 4B. (1222 aa)
	phf2	PHD finger protein 2. (991 aa)
	kdm3b	Lysine (K)-specific demethylase 3B. (1788 aa)
	kdm4a	PHD-type domain-containing protein. (292 aa)
	kdm7a	Lysine (K)-specific demethylase 7Ab. (847 aa)
	kdm4c	Lysine (K)-specific demethylase 4C. (1534 aa)
	ENSCVAP00000019490	Lysine (K)-specific demethylase 4A, genome duplicate b. (357 aa)
	ENSCVAP00000024399	Uncharacterized protein. (271 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (856 aa)
	LOC107102789	Uncharacterized protein. (595 aa)
	phf8	PHD finger protein 8. (1023 aa)
	ENSCVAP00000032681	Uncharacterized protein. (201 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000019490	ENSCVAP00000032681	ENSCVAP00000019490	ENSCVAP00000032681	Lysine (K)-specific demethylase 4A, genome duplicate b.	Uncharacterized protein.	0.898
ENSCVAP00000019490	kdm1a	ENSCVAP00000019490	ENSCVAP00000028102	Lysine (K)-specific demethylase 4A, genome duplicate b.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.554
ENSCVAP00000019490	kdm4a	ENSCVAP00000019490	ENSCVAP00000016512	Lysine (K)-specific demethylase 4A, genome duplicate b.	PHD-type domain-containing protein.	0.437
ENSCVAP00000024399	kdm1a	ENSCVAP00000024399	ENSCVAP00000028102	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.433
ENSCVAP00000032681	ENSCVAP00000019490	ENSCVAP00000032681	ENSCVAP00000019490	Uncharacterized protein.	Lysine (K)-specific demethylase 4A, genome duplicate b.	0.898
ENSCVAP00000032681	LOC107102789	ENSCVAP00000032681	ENSCVAP00000030807	Uncharacterized protein.	Uncharacterized protein.	0.851
ENSCVAP00000032681	kdm1a	ENSCVAP00000032681	ENSCVAP00000028102	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.554
LOC107093321	kdm1a	ENSCVAP00000000166	ENSCVAP00000028102	Lysine (K)-specific demethylase 4B.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.554
LOC107093321	kdm3b	ENSCVAP00000000166	ENSCVAP00000016504	Lysine (K)-specific demethylase 4B.	Lysine (K)-specific demethylase 3B.	0.645
LOC107102789	ENSCVAP00000032681	ENSCVAP00000030807	ENSCVAP00000032681	Uncharacterized protein.	Uncharacterized protein.	0.851
LOC107102789	kdm1a	ENSCVAP00000030807	ENSCVAP00000028102	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.554
LOC107102789	kdm3b	ENSCVAP00000030807	ENSCVAP00000016504	Uncharacterized protein.	Lysine (K)-specific demethylase 3B.	0.410
kdm1a	ENSCVAP00000019490	ENSCVAP00000028102	ENSCVAP00000019490	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Lysine (K)-specific demethylase 4A, genome duplicate b.	0.554
kdm1a	ENSCVAP00000024399	ENSCVAP00000028102	ENSCVAP00000024399	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Uncharacterized protein.	0.433
kdm1a	ENSCVAP00000032681	ENSCVAP00000028102	ENSCVAP00000032681	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Uncharacterized protein.	0.554
kdm1a	LOC107093321	ENSCVAP00000028102	ENSCVAP00000000166	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Lysine (K)-specific demethylase 4B.	0.554
kdm1a	LOC107102789	ENSCVAP00000028102	ENSCVAP00000030807	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Uncharacterized protein.	0.554
kdm1a	kdm3b	ENSCVAP00000028102	ENSCVAP00000016504	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Lysine (K)-specific demethylase 3B.	0.433
kdm1a	kdm4a	ENSCVAP00000028102	ENSCVAP00000016512	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	PHD-type domain-containing protein.	0.554
kdm1a	kdm4c	ENSCVAP00000028102	ENSCVAP00000016900	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Lysine (K)-specific demethylase 4C.	0.554