(31 nodes) Tumor necrosis factor-mediated signaling pathway network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdip1	Cell death-inducing p53 target 1. (221 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (319 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	LOC107103870	TNF receptor-associated factor. (428 aa)
	LOC107095771	TRAF3 interacting protein 2-like. (439 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (655 aa)
	LOC107086576	Protein kinase domain-containing protein. (740 aa)
	ENSCVAP00000007406	TNFR-Cys domain-containing protein. (209 aa)
	LOC107101899	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (267 aa)
	TNFRSF19	TNF receptor superfamily member 19. (369 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	LOC107095483	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (304 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC107092860	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (597 aa)
	ENSCVAP00000010382	Zgc:174906. (216 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (515 aa)
	ENSCVAP00000017074	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (64 aa)
	LOC107087916	Uncharacterized protein. (437 aa)
	plvap	Plasmalemma vesicle associated protein b. (422 aa)
	traf3ip2	SEFIR domain-containing protein. (290 aa)
	LOC107093456	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (254 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1013 aa)
	ENSCVAP00000032625	Uncharacterized protein. (347 aa)
	commd7	COMM domain containing 7. (71 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (710 aa)
	card14	Caspase recruitment domain family, member 14. (963 aa)
	ENSCVAP00000024868	CARD domain-containing protein. (82 aa)
	ENSCVAP00000026250	TNFR-Cys domain-containing protein. (385 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSCVAP00000017074	ENSCVAP00000001539	ENSCVAP00000017074	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.822
CHUK	LOC107086576	ENSCVAP00000001539	ENSCVAP00000002893	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.944
CHUK	LOC107092860	ENSCVAP00000001539	ENSCVAP00000001591	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.579
CHUK	LOC107095483	ENSCVAP00000001539	ENSCVAP00000009748	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC107103870	ENSCVAP00000001539	ENSCVAP00000002344	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.579
CHUK	ikbkb	ENSCVAP00000001539	ENSCVAP00000030160	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.952
CHUK	nfkbia	ENSCVAP00000001539	ENSCVAP00000001881	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.958
CHUK	tnfrsf1a	ENSCVAP00000001539	ENSCVAP00000000255	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor receptor superfamily, member 1a.	0.535
CHUK	traf2	ENSCVAP00000001539	ENSCVAP00000014412	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.579
CHUK	traf3	ENSCVAP00000001539	ENSCVAP00000008442	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.764
CHUK	traf6	ENSCVAP00000001539	ENSCVAP00000013118	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
ENSCVAP00000010382	ENSCVAP00000024868	ENSCVAP00000010382	ENSCVAP00000024868	Zgc:174906.	CARD domain-containing protein.	0.457
ENSCVAP00000017074	CHUK	ENSCVAP00000017074	ENSCVAP00000001539	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.822
ENSCVAP00000017074	ENSCVAP00000026250	ENSCVAP00000017074	ENSCVAP00000026250	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.998
ENSCVAP00000017074	LOC107086576	ENSCVAP00000017074	ENSCVAP00000002893	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Protein kinase domain-containing protein.	0.886
ENSCVAP00000017074	LOC107092860	ENSCVAP00000017074	ENSCVAP00000001591	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.823
ENSCVAP00000017074	LOC107093456	ENSCVAP00000017074	ENSCVAP00000019931	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.580
ENSCVAP00000017074	LOC107095483	ENSCVAP00000017074	ENSCVAP00000009748	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.585
ENSCVAP00000017074	LOC107101899	ENSCVAP00000017074	ENSCVAP00000008225	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.622
ENSCVAP00000017074	LOC107103870	ENSCVAP00000017074	ENSCVAP00000002344	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor.	0.823