STRINGSTRING
LOC107098637 LOC107098637 ENSCVAP00000020299 ENSCVAP00000020299 rnf8 rnf8 cdc73 cdc73 LOC107080723 LOC107080723 ENSCVAP00000028757 ENSCVAP00000028757 ctr9 ctr9 LOC107086853 LOC107086853 LOC107082085 LOC107082085 LOC107095150 LOC107095150 LOC107095145 LOC107095145 ENSCVAP00000007791 ENSCVAP00000007791 wac wac LOC107092437 LOC107092437 rnf40 rnf40
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC107098637E3 ubiquitin protein ligase. (1032 aa)
ENSCVAP00000020299RING-type domain-containing protein. (196 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (502 aa)
LOC107080723RING-type domain-containing protein. (210 aa)
ENSCVAP00000028757RING-type domain-containing protein. (536 aa)
ctr9CTR9 homolog, Paf1/RNA polymerase II complex component. (1146 aa)
LOC107086853WW domain-containing protein. (528 aa)
LOC107082085RING-type domain-containing protein. (263 aa)
LOC107095150RING-type domain-containing protein. (198 aa)
LOC107095145Zgc:66440. (369 aa)
ENSCVAP00000007791RING-type domain-containing protein. (203 aa)
wacWW domain containing adaptor with coiled-coil a. (543 aa)
LOC107092437Si:dkey-3h3.3. (339 aa)
rnf40E3 ubiquitin protein ligase. (1001 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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