(25 nodes) Cellular response to heat network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ywhae	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
	daxx	Death-domain associated protein. (673 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
	LOC107105164	Transcriptional and immune response regulator a. (100 aa)
	LOC107100299	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (724 aa)
	tfec	Transcription factor EC. (395 aa)
	LOC107091048	Marker of proliferation Ki-67. (1794 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1071 aa)
	ENSCVAP00000004363	WW domain-containing protein. (198 aa)
	ENSCVAP00000005439	Heat shock protein nuclear import factor hikeshi. (199 aa)
	st8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (332 aa)
	hsbp1	Heat shock factor binding protein 1a. (77 aa)
	sumo1	Small ubiquitin-related modifier. (76 aa)
	IER5L	Immediate early response 5 like. (296 aa)
	LOC107084826	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (356 aa)
	ENSCVAP00000011457	Uncharacterized protein. (62 aa)
	LOC107091957	Translocated promoter region b, nuclear basket protein. (2192 aa)
	tpr	Translocated promoter region a, nuclear basket protein. (1972 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (674 aa)
	ENSCVAP00000015714	Uncharacterized protein. (81 aa)
	hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (724 aa)
	LOC107100300	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (731 aa)
	nf1	Neurofibromin 1b. (2729 aa)
	LOC107081867	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (255 aa)
	IER5L-2	Immediate early response 5-like. (271 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	ENSCVAP00000005439	ENSCVAP00000014804	ENSCVAP00000005439	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein nuclear import factor hikeshi.	0.602
CLPB	ENSCVAP00000015714	ENSCVAP00000014804	ENSCVAP00000015714	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Uncharacterized protein.	0.714
CLPB	LOC107100299	ENSCVAP00000014804	ENSCVAP00000003477	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.714
CLPB	LOC107100300	ENSCVAP00000014804	ENSCVAP00000022171	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.714
CLPB	hsp90ab1	ENSCVAP00000014804	ENSCVAP00000021437	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.714
ENSCVAP00000004363	LOC107081867	ENSCVAP00000004363	ENSCVAP00000024378	WW domain-containing protein.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	0.409
ENSCVAP00000004363	ywhae	ENSCVAP00000004363	ENSCVAP00000011531	WW domain-containing protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.409
ENSCVAP00000005439	CLPB	ENSCVAP00000005439	ENSCVAP00000014804	Heat shock protein nuclear import factor hikeshi.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.602
ENSCVAP00000011457	ENSCVAP00000015714	ENSCVAP00000011457	ENSCVAP00000015714	Uncharacterized protein.	Uncharacterized protein.	0.424
ENSCVAP00000011457	LOC107100299	ENSCVAP00000011457	ENSCVAP00000003477	Uncharacterized protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.424
ENSCVAP00000011457	LOC107100300	ENSCVAP00000011457	ENSCVAP00000022171	Uncharacterized protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.424
ENSCVAP00000011457	hsp90ab1	ENSCVAP00000011457	ENSCVAP00000021437	Uncharacterized protein.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.424
ENSCVAP00000015714	CLPB	ENSCVAP00000015714	ENSCVAP00000014804	Uncharacterized protein.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.714
ENSCVAP00000015714	ENSCVAP00000011457	ENSCVAP00000015714	ENSCVAP00000011457	Uncharacterized protein.	Uncharacterized protein.	0.424
ENSCVAP00000015714	LOC107081867	ENSCVAP00000015714	ENSCVAP00000024378	Uncharacterized protein.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	0.526
ENSCVAP00000015714	hsbp1	ENSCVAP00000015714	ENSCVAP00000008605	Uncharacterized protein.	Heat shock factor binding protein 1a.	0.516
ENSCVAP00000015714	ywhae	ENSCVAP00000015714	ENSCVAP00000011531	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.526
LOC107081867	ENSCVAP00000004363	ENSCVAP00000024378	ENSCVAP00000004363	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	WW domain-containing protein.	0.409
LOC107081867	ENSCVAP00000015714	ENSCVAP00000024378	ENSCVAP00000015714	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Uncharacterized protein.	0.526
LOC107081867	LOC107100299	ENSCVAP00000024378	ENSCVAP00000003477	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.526