(113 nodes) Response to tumor necrosis factor network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107089035	Uncharacterized protein. (500 aa)
	LOC107103361	SCY domain-containing protein. (99 aa)
	LOC107103362	SCY domain-containing protein. (99 aa)
	ENSCVAP00000031059	Ig-like domain-containing protein. (181 aa)
	LOC107087944	C-C motif chemokine. (95 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (710 aa)
	LOC107099365	SCY domain-containing protein. (99 aa)
	LOC107084711	Zinc finger CCCH-type containing 12A. (619 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	ENSCVAP00000028604	Uncharacterized protein. (237 aa)
	cdip1	Cell death-inducing p53 target 1. (221 aa)
	LOC107096537	C-C motif chemokine. (93 aa)
	ENSCVAP00000027757	SCY domain-containing protein. (92 aa)
	ENSCVAP00000027745	C-C motif chemokine. (94 aa)
	nr1d1	Nuclear receptor subfamily 1, group d, member 1. (618 aa)
	gsdme	Gasdermin Eb. (463 aa)
	ENSCVAP00000026250	TNFR-Cys domain-containing protein. (385 aa)
	akap12	A kinase (PRKA) anchor protein 12b. (1396 aa)
	LOC107084353	Uncharacterized protein. (466 aa)
	ENSCVAP00000025291	Uncharacterized protein. (465 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1216 aa)
	ENSCVAP00000024868	CARD domain-containing protein. (82 aa)
	LOC107091641	Sb:cb81. (415 aa)
	zfp36l1	Zinc finger protein 36, C3H type-like 1a. (368 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (722 aa)
	LOC107100241	Deoxyribonuclease; Belongs to the DNase I family. (297 aa)
	card14	Caspase recruitment domain family, member 14. (963 aa)
	commd7	COMM domain containing 7. (71 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1013 aa)
	LOC107083844	GTP cyclohydrolase 1. (254 aa)
	LOC107085523	GTP cyclohydrolase 2. (241 aa)
	LOC107092314	C-C motif chemokine. (92 aa)
	ENSCVAP00000022592	Uncharacterized protein. (197 aa)
	Slamf1	IG domain-containing protein. (145 aa)
	ENSCVAP00000022427	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (103 aa)
	LOC107098013	Deoxyribonuclease 1 like 4, tandem duplicate 1. (342 aa)
	ENSCVAP00000021268	Ig-like domain-containing protein. (297 aa)
	LOC107082055	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (499 aa)
	LOC107093456	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (254 aa)
	traf3ip2	SEFIR domain-containing protein. (290 aa)
	gfer	Sulfhydryl oxidase. (195 aa)
	gba	Glucosylceramidase. (520 aa)
	plvap	Plasmalemma vesicle associated protein b. (422 aa)
	tmem130	Transmembrane protein 130. (308 aa)
	Irg1	Aconitate decarboxylase 1. (535 aa)
	YTHDC2	YTH domain containing 2. (1387 aa)
	LOC107089037	Immunoresponsive gene 1, like. (486 aa)
	LOC107102670	Si:dkey-206d17.12. (600 aa)
	tank	TRAF family member-associated NFKB activator. (335 aa)
	ENSCVAP00000000888	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (310 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	LOC107093437	Sphingomyelin phosphodiesterase 4. (648 aa)
	ENSCVAP00000017608	SCY domain-containing protein. (108 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (608 aa)
	LOC107087916	Uncharacterized protein. (437 aa)
	nub1	Negative regulator of ubiquitin-like proteins 1. (492 aa)
	ENSCVAP00000017432	Uncharacterized protein. (112 aa)
	zfp36l2	Uncharacterized protein. (413 aa)
	ENSCVAP00000017097	Uncharacterized protein; Belongs to the peptidase C14A family. (340 aa)
	ENSCVAP00000017074	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (64 aa)
	ENSCVAP00000017041	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (149 aa)
	LOC107086824	Uncharacterized protein; Belongs to the peptidase C14A family. (477 aa)
	LOC107085767	Nuclear factor, erythroid 2-like 2a. (653 aa)
	LOC107091921	Zgc:162730. (414 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (225 aa)
	trim32	Tripartite motif containing 32. (679 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (515 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	ENSCVAP00000013874	C-C motif chemokine. (94 aa)
	LOC107096993	SCY domain-containing protein. (108 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	LOC107096536	C-C motif chemokine. (91 aa)
	LOC107096538	C-C motif chemokine. (101 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	LOC107091523	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	ENSCVAP00000010514	Cytochrome P450, family 1, subfamily C, polypeptide 2. (338 aa)
	ENSCVAP00000010443	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (529 aa)
	ENSCVAP00000010382	Zgc:174906. (216 aa)
	LOC107090382	Uncharacterized protein. (321 aa)
	LOC107092340	Uncharacterized protein. (303 aa)
	ILK	Integrin linked kinase. (452 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	LOC107095771	TRAF3 interacting protein 2-like. (439 aa)
	LOC107092860	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (597 aa)
	LOC107095483	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (304 aa)
	adamts13	ADAM metallopeptidase with thrombospondin type 1 motif, 13. (1328 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (416 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	TNFRSF19	TNF receptor superfamily member 19. (369 aa)
	LOC107093866	NK3 homeobox 1. (192 aa)
	LOC107101899	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (267 aa)
	asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (334 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (474 aa)
	LOC107082057	Nuclear factor, erythroid 2-like 2a. (647 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (319 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (684 aa)
	LOC107095718	SCY domain-containing protein. (110 aa)
	LOC107103870	TNF receptor-associated factor. (428 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (655 aa)
	bag4	BCL2 associated athanogene 4. (372 aa)
	LOC107086576	Protein kinase domain-containing protein. (740 aa)
	LOC107092313	C-C motif chemokine. (104 aa)
	sirt1	Sirtuin 1. (691 aa)
	adam10	Uncharacterized protein. (752 aa)
	LOC107088618	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (527 aa)
	LOC107083215	SCY domain-containing protein. (99 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (627 aa)
	ENSCVAP00000007406	TNFR-Cys domain-containing protein. (209 aa)
	ENSCVAP00000032625	Uncharacterized protein. (347 aa)
	ENSCVAP00000031987	SCY domain-containing protein. (120 aa)
	brca1	Uncharacterized protein. (1314 aa)
	ENSCVAP00000031693	Uncharacterized protein. (193 aa)
	ocstamp	Osteoclast stimulatory transmembrane protein. (468 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSCVAP00000017074	ENSCVAP00000001539	ENSCVAP00000017074	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.822
CHUK	ENSCVAP00000022592	ENSCVAP00000001539	ENSCVAP00000022592	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.432
CHUK	LOC107086576	ENSCVAP00000001539	ENSCVAP00000002893	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.944
CHUK	LOC107090382	ENSCVAP00000001539	ENSCVAP00000010305	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.432
CHUK	LOC107092860	ENSCVAP00000001539	ENSCVAP00000001591	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.579
CHUK	LOC107095483	ENSCVAP00000001539	ENSCVAP00000009748	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC107098013	ENSCVAP00000001539	ENSCVAP00000021587	Component of inhibitor of nuclear factor kappa B kinase complex.	Deoxyribonuclease 1 like 4, tandem duplicate 1.	0.432
CHUK	LOC107100241	ENSCVAP00000001539	ENSCVAP00000023624	Component of inhibitor of nuclear factor kappa B kinase complex.	Deoxyribonuclease; Belongs to the DNase I family.	0.432
CHUK	LOC107103870	ENSCVAP00000001539	ENSCVAP00000002344	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.579
CHUK	ikbkb	ENSCVAP00000001539	ENSCVAP00000030160	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.952
CHUK	nfkbia	ENSCVAP00000001539	ENSCVAP00000001881	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.958
CHUK	ripk1	ENSCVAP00000001539	ENSCVAP00000004942	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.693
CHUK	tank	ENSCVAP00000001539	ENSCVAP00000001089	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NFKB activator.	0.521
CHUK	tnfrsf1a	ENSCVAP00000001539	ENSCVAP00000000255	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor receptor superfamily, member 1a.	0.535
CHUK	traf2	ENSCVAP00000001539	ENSCVAP00000014412	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.579
CHUK	traf3	ENSCVAP00000001539	ENSCVAP00000008442	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.764
CHUK	traf6	ENSCVAP00000001539	ENSCVAP00000013118	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
DCSTAMP	LOC107101899	ENSCVAP00000007735	ENSCVAP00000008225	Dendrocyte expressed seven transmembrane protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.542
DCSTAMP	ocstamp	ENSCVAP00000007735	ENSCVAP00000031682	Dendrocyte expressed seven transmembrane protein.	Osteoclast stimulatory transmembrane protein.	0.627
DCSTAMP	traf6	ENSCVAP00000007735	ENSCVAP00000013118	Dendrocyte expressed seven transmembrane protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.485