STRINGSTRING
Polh Polh pnkp pnkp LOC107085266 LOC107085266 APLF APLF LOC107085383 LOC107085383 LOC107095754 LOC107095754 tp53bp1 tp53bp1 shld2 shld2 sirt6 sirt6 Nhej1 Nhej1 slf1 slf1 ENSCVAP00000007153 ENSCVAP00000007153 ENSCVAP00000007189 ENSCVAP00000007189 LOC107094393 LOC107094393 prpf19 prpf19 LOC107097796 LOC107097796 smarcad1 smarcad1 vcp vcp rnf168 rnf168 ufl1 ufl1 rif1 rif1 parp1 parp1 ENSCVAP00000031729 ENSCVAP00000031729 sirt7 sirt7 LOC107082340 LOC107082340 ENSCVAP00000030388 ENSCVAP00000030388 poll poll actr3 actr3 ENSCVAP00000029807 ENSCVAP00000029807 rad51 rad51 mre11 mre11 ENSCVAP00000029582 ENSCVAP00000029582 LOC107094846 LOC107094846 rad50 rad50 LOC107090597 LOC107090597 ENSCVAP00000026159 ENSCVAP00000026159 hus1 hus1 ENSCVAP00000025174 ENSCVAP00000025174 ENSCVAP00000024720 ENSCVAP00000024720 ACTR3 ACTR3 LOC107094019 LOC107094019 arpc4 arpc4 rnf8 rnf8 arpc2 arpc2 arpc3 arpc3 parp3 parp3 ENSCVAP00000019965 ENSCVAP00000019965 paxx paxx rnf169 rnf169 tonsl tonsl ddb1 ddb1 wrap53 wrap53 Rbbp8 Rbbp8 rad18 rad18 rpa3 rpa3 timeless timeless
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PolhPolymerase (DNA directed), eta. (298 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (600 aa)
LOC107085266Zgc:101810; Belongs to the actin family. (394 aa)
APLFAprataxin and PNKP like factor. (438 aa)
LOC107085383Structural maintenance of chromosomes flexible hinge domain containing 1. (1708 aa)
LOC107095754Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1349 aa)
shld2Si:ch211-134m17.9. (772 aa)
sirt6Sirtuin 6. (349 aa)
Nhej1Nonhomologous end-joining factor 1. (263 aa)
slf1SMC5-SMC6 complex localization factor 1. (877 aa)
ENSCVAP00000007153HD domain-containing protein. (144 aa)
ENSCVAP00000007189HD domain-containing protein. (161 aa)
LOC107094393Zgc:136908; Belongs to the AAA ATPase family. (808 aa)
prpf19Pre-mRNA processing factor 19. (505 aa)
LOC107097796Uncharacterized protein. (250 aa)
smarcad1Uncharacterized protein. (835 aa)
vcpValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (426 aa)
ufl1UFM1-specific ligase 1. (736 aa)
rif1Replication timing regulatory factor 1. (2380 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
ENSCVAP00000031729WD_REPEATS_REGION domain-containing protein. (328 aa)
sirt7Sirtuin 7. (409 aa)
LOC107082340SET domain and mariner transposase fusion gene. (283 aa)
ENSCVAP00000030388Si:ch1073-75f15.2. (107 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (567 aa)
actr3Uncharacterized protein; Belongs to the actin family. (416 aa)
ENSCVAP00000029807Actin related protein 3. (129 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
ENSCVAP00000029582SMC hinge domain-containing protein. (570 aa)
LOC107094846HD domain-containing protein. (424 aa)
rad50RAD50 homolog, double strand break repair protein. (1274 aa)
LOC107090597Uncharacterized protein. (1276 aa)
ENSCVAP00000026159Uncharacterized protein. (289 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
ENSCVAP00000025174HD domain-containing protein. (393 aa)
ENSCVAP00000024720SMC hinge domain-containing protein. (1613 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (433 aa)
LOC107094019Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
arpc4Actin related protein 2/3 complex subunit 4. (230 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
parp3Poly [ADP-ribose] polymerase. (525 aa)
ENSCVAP00000019965WGR domain-containing protein. (153 aa)
paxxUncharacterized protein. (181 aa)
rnf169Ring finger protein 169. (572 aa)
tonslTonsoku-like, DNA repair protein. (1433 aa)
ddb1Damage-specific DNA binding protein 1. (1080 aa)
wrap53WD repeat containing, antisense to TP53. (507 aa)
Rbbp8SAE2 domain-containing protein. (75 aa)
rad18RAD18 E3 ubiquitin protein ligase. (495 aa)
rpa3Replication protein A3. (122 aa)
timelessTimeless circadian clock. (1251 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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