(18 nodes) Regulation of isotype switching network (Cyprinodon variegatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	LOC107096940	SET domain-containing protein. (1939 aa)
	LOC107091169	ATPase family AAA domain containing 5a. (1526 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1349 aa)
	nsd2	Nuclear receptor binding SET domain protein 2. (1456 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	LOC107097796	Uncharacterized protein. (250 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	LOC107083714	CD40 molecule, TNF receptor superfamily member 5. (300 aa)
	ENSCVAP00000019965	WGR domain-containing protein. (153 aa)
	parp3	Poly [ADP-ribose] polymerase. (525 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (719 aa)
	exosc3	Exosome component 3. (244 aa)
	hmces	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (359 aa)
	tbx21	T-box transcription factor 21. (612 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (966 aa)
	thoc1	THO complex 1. (654 aa)
	rif1	Replication timing regulatory factor 1. (2380 aa)
	kmt5b	Lysine methyltransferase 5B. (855 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107083714	PTPRC	ENSCVAP00000009125	ENSCVAP00000027357	CD40 molecule, TNF receptor superfamily member 5.	Protein tyrosine phosphatase receptor type C.	0.444
LOC107091169	msh2	ENSCVAP00000001775	ENSCVAP00000004483	ATPase family AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.475
LOC107096940	tp53bp1	ENSCVAP00000013661	ENSCVAP00000002727	SET domain-containing protein.	Tumor protein p53 binding protein, 1.	0.469
PTPRC	LOC107083714	ENSCVAP00000027357	ENSCVAP00000009125	Protein tyrosine phosphatase receptor type C.	CD40 molecule, TNF receptor superfamily member 5.	0.444
PTPRC	tbx21	ENSCVAP00000027357	ENSCVAP00000026831	Protein tyrosine phosphatase receptor type C.	T-box transcription factor 21.	0.418
kmt5b	tp53bp1	ENSCVAP00000032670	ENSCVAP00000002727	Lysine methyltransferase 5B.	Tumor protein p53 binding protein, 1.	0.469
mlh1	msh2	ENSCVAP00000022067	ENSCVAP00000004483	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.995
msh2	LOC107091169	ENSCVAP00000004483	ENSCVAP00000001775	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	ATPase family AAA domain containing 5a.	0.475
msh2	mlh1	ENSCVAP00000004483	ENSCVAP00000022067	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.995
nsd2	rif1	ENSCVAP00000003908	ENSCVAP00000032456	Nuclear receptor binding SET domain protein 2.	Replication timing regulatory factor 1.	0.571
nsd2	tp53bp1	ENSCVAP00000003908	ENSCVAP00000002727	Nuclear receptor binding SET domain protein 2.	Tumor protein p53 binding protein, 1.	0.721
rif1	nsd2	ENSCVAP00000032456	ENSCVAP00000003908	Replication timing regulatory factor 1.	Nuclear receptor binding SET domain protein 2.	0.571
rif1	tp53bp1	ENSCVAP00000032456	ENSCVAP00000002727	Replication timing regulatory factor 1.	Tumor protein p53 binding protein, 1.	0.802
tbx21	PTPRC	ENSCVAP00000026831	ENSCVAP00000027357	T-box transcription factor 21.	Protein tyrosine phosphatase receptor type C.	0.418
tp53bp1	LOC107096940	ENSCVAP00000002727	ENSCVAP00000013661	Tumor protein p53 binding protein, 1.	SET domain-containing protein.	0.469
tp53bp1	kmt5b	ENSCVAP00000002727	ENSCVAP00000032670	Tumor protein p53 binding protein, 1.	Lysine methyltransferase 5B.	0.469
tp53bp1	nsd2	ENSCVAP00000002727	ENSCVAP00000003908	Tumor protein p53 binding protein, 1.	Nuclear receptor binding SET domain protein 2.	0.721
tp53bp1	rif1	ENSCVAP00000002727	ENSCVAP00000032456	Tumor protein p53 binding protein, 1.	Replication timing regulatory factor 1.	0.802