(9 nodes) Positive regulation of cholesterol biosynthetic process network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107089939	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (172 aa)
	rusc1	Uncharacterized protein. (1858 aa)
	LOC107095920	ABC transporter domain-containing protein. (642 aa)
	srebf2	Sterol regulatory element binding transcription factor 2. (1173 aa)
	LOC107091830	ATP-binding cassette, sub-family G (WHITE), member 1. (555 aa)
	scap	SREBF chaperone. (1317 aa)
	LOC107101656	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (160 aa)
	abcg4	ATP-binding cassette, sub-family G (WHITE), member 4a. (643 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1178 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107091830	srebf2	ENSCVAP00000031639	ENSCVAP00000003267	ATP-binding cassette, sub-family G (WHITE), member 1.	Sterol regulatory element binding transcription factor 2.	0.487
LOC107095920	abcg4	ENSCVAP00000030559	ENSCVAP00000026836	ABC transporter domain-containing protein.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.901
abcg4	LOC107095920	ENSCVAP00000026836	ENSCVAP00000030559	ATP-binding cassette, sub-family G (WHITE), member 4a.	ABC transporter domain-containing protein.	0.901
scap	srebf1	ENSCVAP00000015987	ENSCVAP00000020909	SREBF chaperone.	Sterol regulatory element binding transcription factor 1.	0.963
scap	srebf2	ENSCVAP00000015987	ENSCVAP00000003267	SREBF chaperone.	Sterol regulatory element binding transcription factor 2.	0.963
srebf1	scap	ENSCVAP00000020909	ENSCVAP00000015987	Sterol regulatory element binding transcription factor 1.	SREBF chaperone.	0.963
srebf1	srebf2	ENSCVAP00000020909	ENSCVAP00000003267	Sterol regulatory element binding transcription factor 1.	Sterol regulatory element binding transcription factor 2.	0.482
srebf2	LOC107091830	ENSCVAP00000003267	ENSCVAP00000031639	Sterol regulatory element binding transcription factor 2.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.487
srebf2	scap	ENSCVAP00000003267	ENSCVAP00000015987	Sterol regulatory element binding transcription factor 2.	SREBF chaperone.	0.963
srebf2	srebf1	ENSCVAP00000003267	ENSCVAP00000020909	Sterol regulatory element binding transcription factor 2.	Sterol regulatory element binding transcription factor 1.	0.482