(67 nodes) Regulation of myeloid cell differentiation network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2406 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	LOC107089536	Pentaxin. (221 aa)
	faxdc2	Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (333 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (268 aa)
	LOC107103984	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (865 aa)
	ocstamp	Osteoclast stimulatory transmembrane protein. (468 aa)
	ctr9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1146 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1112 aa)
	LOC107096537	C-C motif chemokine. (93 aa)
	ENSCVAP00000027757	SCY domain-containing protein. (92 aa)
	fam210b	Family with sequence similarity 210 member B. (275 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (502 aa)
	nf1	Neurofibromin 1b. (2729 aa)
	tmem178a	Transmembrane protein 178. (335 aa)
	fstl3	Follistatin-like 3 (secreted glycoprotein). (250 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (621 aa)
	meis2	Meis homeobox 2a. (478 aa)
	tmem64	Transmembrane protein 64. (346 aa)
	LOC107082055	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (499 aa)
	mturn	Maturin, neural progenitor differentiation regulator homolog (Xenopus). (129 aa)
	LOC107100387	Transcription factor binding to IGHM enhancer 3b. (448 aa)
	LOC107093302	Leucine rich repeat containing 17. (449 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (687 aa)
	LOC107082188	Uncharacterized protein. (420 aa)
	tesc	Tescalcin a. (217 aa)
	LOC107091264	Tescalcin b. (215 aa)
	LOC107090721	CCAAT enhancer binding protein beta. (287 aa)
	ENSCVAP00000017097	Uncharacterized protein; Belongs to the peptidase C14A family. (340 aa)
	ENSCVAP00000017074	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (64 aa)
	ENSCVAP00000017041	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (149 aa)
	LOC107086824	Uncharacterized protein; Belongs to the peptidase C14A family. (477 aa)
	LOC107082335	Melanocyte inducing transcription factor a. (404 aa)
	LOC107103383	C1q domain-containing protein. (238 aa)
	pithd1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (211 aa)
	hax1	HCLS1 associated protein X-1. (304 aa)
	LOC107094857	Zgc:158254. (403 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (312 aa)
	rb1	Retinoblastoma 1. (912 aa)
	LOC107095483	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (304 aa)
	LOC107090375	Uncharacterized protein. (271 aa)
	LOC107104179	Pentaxin. (246 aa)
	il34	Interleukin 34. (221 aa)
	LOC107100094	Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum). (499 aa)
	LOC107081269	Pentaxin. (228 aa)
	LOC107102485	Apoptotic chromatin condensation inducer 1b. (1176 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (474 aa)
	cnot4	CCR4-NOT transcription complex, subunit 4a. (799 aa)
	TNFRSF11B	TNF receptor superfamily member 11b. (405 aa)
	gata1	Uncharacterized protein. (256 aa)
	gabpa	GA binding protein transcription factor subunit alpha. (439 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1786 aa)
	ENSCVAP00000006089	G_PROTEIN_RECEP_F1_2 domain-containing protein. (335 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (627 aa)
	Acin1	SAP domain-containing protein. (1043 aa)
	acin1	Apoptotic chromatin condensation inducer 1a. (575 aa)
	LOC107101526	Uncharacterized protein. (987 aa)
	med12	Mediator complex subunit 12. (2062 aa)
	MITF	Melanocyte inducing transcription factor b. (512 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (319 aa)
	LOC107095752	Meis homeobox 1 b. (387 aa)
	lef1	Lymphoid enhancer-binding factor 1. (378 aa)
	ankrd54	Ankyrin repeat domain 54. (324 aa)
	tfe3	BHLH domain-containing protein. (474 aa)
	LOC107100171	GATA binding protein 1a. (426 aa)
	LOC107101899	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (267 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acin1	LOC107102485	ENSCVAP00000004749	ENSCVAP00000008087	SAP domain-containing protein.	Apoptotic chromatin condensation inducer 1b.	0.900
Acin1	acin1	ENSCVAP00000004749	ENSCVAP00000004742	SAP domain-containing protein.	Apoptotic chromatin condensation inducer 1a.	0.827
DCSTAMP	LOC107101899	ENSCVAP00000007735	ENSCVAP00000008225	Dendrocyte expressed seven transmembrane protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.542
DCSTAMP	ocstamp	ENSCVAP00000007735	ENSCVAP00000031682	Dendrocyte expressed seven transmembrane protein.	Osteoclast stimulatory transmembrane protein.	0.627
ENSCVAP00000017041	ENSCVAP00000017074	ENSCVAP00000017041	ENSCVAP00000017074	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.721
ENSCVAP00000017041	ripk1	ENSCVAP00000017041	ENSCVAP00000004942	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.887
ENSCVAP00000017074	ENSCVAP00000017041	ENSCVAP00000017074	ENSCVAP00000017041	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.721
ENSCVAP00000017074	ENSCVAP00000017097	ENSCVAP00000017074	ENSCVAP00000017097	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.721
ENSCVAP00000017074	ENSCVAP00000027757	ENSCVAP00000017074	ENSCVAP00000027757	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	SCY domain-containing protein.	0.728
ENSCVAP00000017074	LOC107082055	ENSCVAP00000017074	ENSCVAP00000021001	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.829
ENSCVAP00000017074	LOC107082188	ENSCVAP00000017074	ENSCVAP00000019438	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.656
ENSCVAP00000017074	LOC107086824	ENSCVAP00000017074	ENSCVAP00000017025	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.829
ENSCVAP00000017074	LOC107090375	ENSCVAP00000017074	ENSCVAP00000009607	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.503
ENSCVAP00000017074	LOC107090721	ENSCVAP00000017074	ENSCVAP00000017803	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	CCAAT enhancer binding protein beta.	0.487
ENSCVAP00000017074	LOC107095483	ENSCVAP00000017074	ENSCVAP00000009748	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.585
ENSCVAP00000017074	LOC107096537	ENSCVAP00000017074	ENSCVAP00000027782	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	C-C motif chemokine.	0.728
ENSCVAP00000017074	LOC107101899	ENSCVAP00000017074	ENSCVAP00000008225	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.622
ENSCVAP00000017074	LOC107103699	ENSCVAP00000017074	ENSCVAP00000008432	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.642
ENSCVAP00000017074	nfkbia	ENSCVAP00000017074	ENSCVAP00000001881	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.585
ENSCVAP00000017074	ripk1	ENSCVAP00000017074	ENSCVAP00000004942	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.992