(56 nodes) Regulation of osteoblast differentiation network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccn1	Cellular communication network factor 1. (375 aa)
	rest	RE1-silencing transcription factor. (999 aa)
	LOC107096868	Bone morphogenetic protein 16. (476 aa)
	LOC107090074	Activating transcription factor 4a. (439 aa)
	WDR63	Uncharacterized protein. (678 aa)
	LOC107097348	Nocturnin. (443 aa)
	LOC107092808	FAM20C golgi associated secretory pathway kinase a. (565 aa)
	LOC107103885	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (360 aa)
	ENSCVAP00000004967	Twist2. (169 aa)
	LOC107095034	Upper zone of growth plate and cartilage matrix associated b. (178 aa)
	bmpr1a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (522 aa)
	LOC107087599	Zinc fingers and homeoboxes 3. (1118 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1052 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC107084241	Insulin-like growth factor binding protein 5a. (250 aa)
	tmem64	Transmembrane protein 64. (346 aa)
	nbr1	NBR1 autophagy cargo receptor a. (1069 aa)
	bmpr1b	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (724 aa)
	rorb	RAR-related orphan receptor B. (485 aa)
	LOC107089450	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
	LOC107091926	Uncharacterized protein. (339 aa)
	LOC107096452	JunD proto-oncogene, AP-1 transcription factor subunit. (274 aa)
	LOC107091036	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
	tnn	Tenascin N. (943 aa)
	il6st	Uncharacterized protein. (885 aa)
	JUND	BZIP domain-containing protein. (296 aa)
	fbxo5	F-box protein 5. (426 aa)
	ENSCVAP00000026779	BHLH domain-containing protein. (162 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (254 aa)
	LOC107083646	SUN domain-containing protein. (1293 aa)
	ENSCVAP00000027729	Multiple endocrine neoplasia I. (444 aa)
	id3	Inhibitor of DNA binding 3. (116 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	acvr2b	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (573 aa)
	ENSCVAP00000031769	Uncharacterized protein. (111 aa)
	GREM1	Gremlin. (184 aa)
	ENSCVAP00000017074	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (64 aa)
	LOC107087916	Uncharacterized protein. (437 aa)
	suco	SUN domain containing ossification factor. (1414 aa)
	LOC107090721	CCAAT enhancer binding protein beta. (287 aa)
	LOC107103972	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (739 aa)
	acvr2a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
	atraid	All-trans retinoic acid-induced differentiation factor. (231 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (268 aa)
	LOC107086215	Insulin-like growth factor binding protein 5a. (267 aa)
	ENSCVAP00000032067	Uncharacterized protein. (245 aa)
	LOC107088457	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
	LOC107086263	Fam20C domain-containing protein. (552 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (145 aa)
	Cebpd	CCAAT enhancer binding protein delta. (143 aa)
	bmp4	Bone morphogenetic protein 4. (399 aa)
	LOC107093243	Nocturnin. (384 aa)
	ucma	Upper zone of growth plate and cartilage matrix associated a. (133 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cebpd	LOC107090074	ENSCVAP00000013811	ENSCVAP00000004441	CCAAT enhancer binding protein delta.	Activating transcription factor 4a.	0.494
Cebpd	LOC107090721	ENSCVAP00000013811	ENSCVAP00000017803	CCAAT enhancer binding protein delta.	CCAAT enhancer binding protein beta.	0.822
ENSCVAP00000017074	LOC107090721	ENSCVAP00000017074	ENSCVAP00000017803	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	CCAAT enhancer binding protein beta.	0.487
ENSCVAP00000017074	igf1	ENSCVAP00000017074	ENSCVAP00000028775	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Insulin-like growth factor 1.	0.548
ENSCVAP00000017074	nbr1	ENSCVAP00000017074	ENSCVAP00000023170	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	NBR1 autophagy cargo receptor a.	0.492
ENSCVAP00000017074	tnfaip6	ENSCVAP00000017074	ENSCVAP00000032462	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Tumor necrosis factor, alpha-induced protein 6.	0.581
ENSCVAP00000027729	JUND	ENSCVAP00000027729	ENSCVAP00000025650	Multiple endocrine neoplasia I.	BZIP domain-containing protein.	0.875
ENSCVAP00000027729	LOC107096452	ENSCVAP00000027729	ENSCVAP00000015765	Multiple endocrine neoplasia I.	JunD proto-oncogene, AP-1 transcription factor subunit.	0.875
GREM1	LOC107096868	ENSCVAP00000015951	ENSCVAP00000003931	Gremlin.	Bone morphogenetic protein 16.	0.717
GREM1	bmp4	ENSCVAP00000015951	ENSCVAP00000019784	Gremlin.	Bone morphogenetic protein 4.	0.717
JUND	ENSCVAP00000027729	ENSCVAP00000025650	ENSCVAP00000027729	BZIP domain-containing protein.	Multiple endocrine neoplasia I.	0.875
JUND	LOC107090721	ENSCVAP00000025650	ENSCVAP00000017803	BZIP domain-containing protein.	CCAAT enhancer binding protein beta.	0.448
LOC107084241	LOC107086263	ENSCVAP00000010341	ENSCVAP00000031911	Insulin-like growth factor binding protein 5a.	Fam20C domain-containing protein.	0.442
LOC107084241	LOC107092808	ENSCVAP00000010341	ENSCVAP00000001593	Insulin-like growth factor binding protein 5a.	FAM20C golgi associated secretory pathway kinase a.	0.442
LOC107084241	igf1	ENSCVAP00000010341	ENSCVAP00000028775	Insulin-like growth factor binding protein 5a.	Insulin-like growth factor 1.	0.935
LOC107086215	LOC107086263	ENSCVAP00000032407	ENSCVAP00000031911	Insulin-like growth factor binding protein 5a.	Fam20C domain-containing protein.	0.442
LOC107086215	LOC107092808	ENSCVAP00000032407	ENSCVAP00000001593	Insulin-like growth factor binding protein 5a.	FAM20C golgi associated secretory pathway kinase a.	0.442
LOC107086215	igf1	ENSCVAP00000032407	ENSCVAP00000028775	Insulin-like growth factor binding protein 5a.	Insulin-like growth factor 1.	0.935
LOC107086263	LOC107084241	ENSCVAP00000031911	ENSCVAP00000010341	Fam20C domain-containing protein.	Insulin-like growth factor binding protein 5a.	0.442
LOC107086263	LOC107086215	ENSCVAP00000031911	ENSCVAP00000032407	Fam20C domain-containing protein.	Insulin-like growth factor binding protein 5a.	0.442