(46 nodes) Positive regulation of endocytosis network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (435 aa)
	LOC107095516	Apolipoprotein Ea. (271 aa)
	LOC107085681	Uncharacterized protein. (380 aa)
	LOC107085118	Uncharacterized protein. (191 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (303 aa)
	ENSCVAP00000028612	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (150 aa)
	ENSCVAP00000028481	Protein kinase domain-containing protein. (510 aa)
	ENSCVAP00000028286	ANK_REP_REGION domain-containing protein. (1004 aa)
	LOC107099960	Clusterin; Belongs to the clusterin family. (464 aa)
	pick1	Protein interacting with prkca 1. (408 aa)
	vtn	Vitronectin a. (543 aa)
	ENSCVAP00000024543	Zgc:123278. (186 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1535 aa)
	LOC107086482	Clusterin; Belongs to the clusterin family. (428 aa)
	ahi1	Abelson helper integration site 1. (1178 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	CDC42	Cell division cycle 42. (191 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (769 aa)
	LOC107083423	Calcyon neuron-specific vesicular protein. (198 aa)
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (223 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (608 aa)
	Cln3	Battenin. (178 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (323 aa)
	ENSCVAP00000016400	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (858 aa)
	gpc3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	GREM1	Gremlin. (184 aa)
	LOC107082950	Apolipoprotein Eb. (335 aa)
	LOC107093644	Low density lipoprotein receptor adaptor protein 1a. (307 aa)
	ankfy1	Ankyrin repeat and FYVE domain containing 1. (926 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (211 aa)
	ENSCVAP00000013494	Uncharacterized protein. (182 aa)
	cd63	Tetraspanin. (240 aa)
	tbc1d5	TBC1 domain family, member 5. (837 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	clu	Clusterin; Belongs to the clusterin family. (457 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (669 aa)
	LOC107086129	Uncharacterized protein. (191 aa)
	dab2	DAB adaptor protein 2. (767 aa)
	LOC107082256	Uncharacterized protein. (191 aa)
	ano6	Anoctamin. (922 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (609 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (570 aa)
	LOC107095718	SCY domain-containing protein. (110 aa)
	scyl2	SCY1 like pseudokinase 2. (922 aa)
	LOC107084203	Vitronectin b. (439 aa)
	fmr1	Fragile X mental retardation 1. (549 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	LOC107093644	ENSCVAP00000014700	ENSCVAP00000015162	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Low density lipoprotein receptor adaptor protein 1a.	0.615
APPL1	ankfy1	ENSCVAP00000014700	ENSCVAP00000014854	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Ankyrin repeat and FYVE domain containing 1.	0.622
APPL1	appl2	ENSCVAP00000014700	ENSCVAP00000001605	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.993
APPL1	ldlrap1	ENSCVAP00000014700	ENSCVAP00000016700	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Low density lipoprotein receptor adaptor protein 1b.	0.615
CDC42	ankfy1	ENSCVAP00000021883	ENSCVAP00000014854	Cell division cycle 42.	Ankyrin repeat and FYVE domain containing 1.	0.460
Cln3	ppt1	ENSCVAP00000017325	ENSCVAP00000029642	Battenin.	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile).	0.676
ENSCVAP00000024543	cd63	ENSCVAP00000024543	ENSCVAP00000008208	Zgc:123278.	Tetraspanin.	0.545
ENSCVAP00000024543	vps28	ENSCVAP00000024543	ENSCVAP00000017602	Zgc:123278.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.981
ENSCVAP00000028286	ENSCVAP00000028481	ENSCVAP00000028286	ENSCVAP00000028481	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.949
ENSCVAP00000028481	ENSCVAP00000028286	ENSCVAP00000028481	ENSCVAP00000028286	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.949
ENSCVAP00000028612	vegfa	ENSCVAP00000028612	ENSCVAP00000023279	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	0.900
LOC107082256	ankfy1	ENSCVAP00000000232	ENSCVAP00000014854	Uncharacterized protein.	Ankyrin repeat and FYVE domain containing 1.	0.452
LOC107082950	LOC107084203	ENSCVAP00000015717	ENSCVAP00000011087	Apolipoprotein Eb.	Vitronectin b.	0.547
LOC107082950	LOC107093644	ENSCVAP00000015717	ENSCVAP00000015162	Apolipoprotein Eb.	Low density lipoprotein receptor adaptor protein 1a.	0.470
LOC107082950	ldlrap1	ENSCVAP00000015717	ENSCVAP00000016700	Apolipoprotein Eb.	Low density lipoprotein receptor adaptor protein 1b.	0.616
LOC107082950	vtn	ENSCVAP00000015717	ENSCVAP00000025368	Apolipoprotein Eb.	Vitronectin a.	0.547
LOC107084203	LOC107082950	ENSCVAP00000011087	ENSCVAP00000015717	Vitronectin b.	Apolipoprotein Eb.	0.547
LOC107084203	LOC107095516	ENSCVAP00000011087	ENSCVAP00000008892	Vitronectin b.	Apolipoprotein Ea.	0.460
LOC107084203	serpine1	ENSCVAP00000011087	ENSCVAP00000009387	Vitronectin b.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.960
LOC107084203	vtn	ENSCVAP00000011087	ENSCVAP00000025368	Vitronectin b.	Vitronectin a.	0.906