(115 nodes) Negative regulation of cell activation network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107095516	Apolipoprotein Ea. (271 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	ENSCVAP00000007634	Cystatin domain-containing protein. (112 aa)
	mertk	C-mer proto-oncogene tyrosine kinase a. (952 aa)
	LOC107099636	Amine oxidase. (520 aa)
	fbxo7	F-box protein 7. (469 aa)
	ENSCVAP00000006154	PGRP domain-containing protein. (118 aa)
	ENSCVAP00000006093	TNFR-Cys domain-containing protein. (259 aa)
	ENSCVAP00000005581	TNFR-Cys domain-containing protein. (102 aa)
	LOC107082678	Fibrinogen C-terminal domain-containing protein. (325 aa)
	LOC107094009	Si:ch211-157b11.8. (426 aa)
	rabgef1	RAB guanine nucleotide exchange factor (GEF) 1. (504 aa)
	RASSF5	Ras association domain family member 5. (270 aa)
	Glmn	Uncharacterized protein. (111 aa)
	il10	Interleukin 10. (184 aa)
	LOC107081922	RAB guanine nucleotide exchange factor (GEF) 1, like. (505 aa)
	LOC107104877	Ig-like domain-containing protein. (344 aa)
	LOC107104878	Ig-like domain-containing protein. (314 aa)
	LOC107087152	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (492 aa)
	ENSCVAP00000002210	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1453 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (684 aa)
	pag1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (448 aa)
	ENSCVAP00000000888	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (310 aa)
	ENSCVAP00000000853	Elastin microfibril interfacer 1b. (871 aa)
	LOC107102670	Si:dkey-206d17.12. (600 aa)
	ENSCVAP00000000578	Ig-like domain-containing protein. (267 aa)
	crtam	Ig-like domain-containing protein. (430 aa)
	vsir	V-set immunoregulatory receptor. (296 aa)
	LOC107082205	Uncharacterized protein. (462 aa)
	fgl2	Fibrinogen-like 2a. (498 aa)
	LOC107085863	Uncharacterized protein. (300 aa)
	tnfrsf13b	TACI-CRD2 domain-containing protein. (260 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (759 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (272 aa)
	LOC107098790	Ig-like domain-containing protein. (206 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1112 aa)
	ENSCVAP00000028561	DBB domain-containing protein. (563 aa)
	LOC107094188	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2022 aa)
	lrfn5	Leucine rich repeat and fibronectin type III domain containing 5b. (797 aa)
	LOC107098764	E3 ubiquitin-protein ligase. (806 aa)
	LOC107098762	E3 ubiquitin-protein ligase. (725 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (346 aa)
	LOC107084711	Zinc finger CCCH-type containing 12A. (619 aa)
	ENSCVAP00000029560	Uncharacterized protein. (215 aa)
	LOC107103455	E3 ubiquitin-protein ligase. (866 aa)
	samsn1	SAM domain, SH3 domain and nuclear localisation signals 1a. (667 aa)
	cbfb	Core-binding factor subunit beta. (188 aa)
	ENSCVAP00000030596	G_PROTEIN_RECEP_F2_4 domain-containing protein. (425 aa)
	ENSCVAP00000030610	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (383 aa)
	LOC107094161	Fibrinogen C-terminal domain-containing protein. (315 aa)
	thoc1	THO complex 1. (654 aa)
	LOC107102760	Uncharacterized protein. (489 aa)
	ENSCVAP00000032180	TNFR-Cys domain-containing protein. (253 aa)
	cd82	Tetraspanin. (253 aa)
	ENSCVAP00000027529	Ig-like domain-containing protein. (273 aa)
	rhbdd3	Rhomboid domain-containing protein. (368 aa)
	ENSCVAP00000026879	TNFR-Cys domain-containing protein. (244 aa)
	tbx21	T-box transcription factor 21. (612 aa)
	nr1d1	Nuclear receptor subfamily 1, group d, member 1. (618 aa)
	ENSCVAP00000026802	Galectin. (294 aa)
	ENSCVAP00000026747	Galectin. (348 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1118 aa)
	ENSCVAP00000026211	Ig-like domain-containing protein. (228 aa)
	LOC107102394	Tetraspanin. (228 aa)
	c1qtnf6	C1q and TNF related 6b. (245 aa)
	AXL	AXL receptor tyrosine kinase. (912 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (622 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1127 aa)
	tyrobp	Uncharacterized protein. (108 aa)
	ENSCVAP00000023924	PGRP domain-containing protein. (244 aa)
	ENSCVAP00000023598	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (505 aa)
	grn	Granulin b. (766 aa)
	tspan8	CD9 molecule b; Belongs to the tetraspanin (TM4SF) family. (212 aa)
	LOC107090045	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (550 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (396 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (718 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	LOC107095682	Elastin microfibril interfacer 1a. (1022 aa)
	IRF1	Interferon regulatory factor. (300 aa)
	LOC107087170	C1q and TNF related 6a. (244 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (388 aa)
	ripor2	RHO family interacting cell polarization regulator 2. (702 aa)
	ENSCVAP00000021083	Ig-like domain-containing protein. (255 aa)
	LOC107084940	Fibrinogen C-terminal domain-containing protein. (515 aa)
	ENSCVAP00000020252	IGv domain-containing protein. (224 aa)
	parp3	Poly [ADP-ribose] polymerase. (525 aa)
	ENSCVAP00000019965	WGR domain-containing protein. (153 aa)
	ENSCVAP00000019920	Uncharacterized protein. (514 aa)
	LOC107101547	Ig-like domain-containing protein. (188 aa)
	LOC107083406	Si:ch211-203k16.3. (433 aa)
	arg2	Arginase. (348 aa)
	LOC107101650	Uncharacterized protein. (270 aa)
	LOC107090721	CCAAT enhancer binding protein beta. (287 aa)
	ripor3	RIPOR family member 3. (989 aa)
	LOC107082923	Arginase. (354 aa)
	sh2b3	SH2B adaptor protein 3. (718 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (770 aa)
	LOC107082950	Apolipoprotein Eb. (335 aa)
	LOC107104639	Ig-like domain-containing protein. (280 aa)
	ENSCVAP00000014721	Ig-like domain-containing protein. (154 aa)
	LOC107085787	Ig-like domain-containing protein. (633 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (822 aa)
	tmem131l	Transmembrane 131 like. (1510 aa)
	ENSCVAP00000012762	GRANULINS domain-containing protein. (77 aa)
	LOC107085866	Uncharacterized protein. (247 aa)
	Atm	Uncharacterized protein. (145 aa)
	ENSCVAP00000011755	TAN domain-containing protein. (119 aa)
	socs6	Suppressor of cytokine signaling 6a. (535 aa)
	LOC107093061	Leucine rich repeat containing 32. (747 aa)
	LOC107091523	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	ENSCVAP00000010507	TNFR-Cys domain-containing protein. (232 aa)
	ENSCVAP00000010481	Galectin. (123 aa)
	LOC107088704	Uncharacterized protein. (468 aa)
	LOC107086939	IRF tryptophan pentad repeat domain-containing protein. (287 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSCVAP00000011755	ENSCVAP00000011758	ENSCVAP00000011755	Uncharacterized protein.	TAN domain-containing protein.	0.922
ENSCVAP00000007634	LOC107082950	ENSCVAP00000007634	ENSCVAP00000015717	Cystatin domain-containing protein.	Apolipoprotein Eb.	0.453
ENSCVAP00000007634	tyrobp	ENSCVAP00000007634	ENSCVAP00000024283	Cystatin domain-containing protein.	Uncharacterized protein.	0.463
ENSCVAP00000010481	LOC107082205	ENSCVAP00000010481	ENSCVAP00000000269	Galectin.	Uncharacterized protein.	0.439
ENSCVAP00000011755	Atm	ENSCVAP00000011755	ENSCVAP00000011758	TAN domain-containing protein.	Uncharacterized protein.	0.922
ENSCVAP00000019920	LOC107103699	ENSCVAP00000019920	ENSCVAP00000008432	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.860
ENSCVAP00000019965	socs6	ENSCVAP00000019965	ENSCVAP00000011332	WGR domain-containing protein.	Suppressor of cytokine signaling 6a.	0.513
ENSCVAP00000026747	LOC107082205	ENSCVAP00000026747	ENSCVAP00000000269	Galectin.	Uncharacterized protein.	0.439
ENSCVAP00000026802	LOC107082205	ENSCVAP00000026802	ENSCVAP00000000269	Galectin.	Uncharacterized protein.	0.439
IRF1	LOC107090721	ENSCVAP00000021742	ENSCVAP00000017803	Interferon regulatory factor.	CCAAT enhancer binding protein beta.	0.421
LOC107081922	rabgef1	ENSCVAP00000003317	ENSCVAP00000004032	RAB guanine nucleotide exchange factor (GEF) 1, like.	RAB guanine nucleotide exchange factor (GEF) 1.	0.571
LOC107082205	ENSCVAP00000010481	ENSCVAP00000000269	ENSCVAP00000010481	Uncharacterized protein.	Galectin.	0.439
LOC107082205	ENSCVAP00000026747	ENSCVAP00000000269	ENSCVAP00000026747	Uncharacterized protein.	Galectin.	0.439
LOC107082205	ENSCVAP00000026802	ENSCVAP00000000269	ENSCVAP00000026802	Uncharacterized protein.	Galectin.	0.439
LOC107082205	LOC107082678	ENSCVAP00000000269	ENSCVAP00000005277	Uncharacterized protein.	Fibrinogen C-terminal domain-containing protein.	0.537
LOC107082205	LOC107088704	ENSCVAP00000000269	ENSCVAP00000010301	Uncharacterized protein.	Uncharacterized protein.	0.678
LOC107082205	LOC107094161	ENSCVAP00000000269	ENSCVAP00000031370	Uncharacterized protein.	Fibrinogen C-terminal domain-containing protein.	0.537
LOC107082205	il10	ENSCVAP00000000269	ENSCVAP00000003674	Uncharacterized protein.	Interleukin 10.	0.436
LOC107082678	LOC107082205	ENSCVAP00000005277	ENSCVAP00000000269	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.537
LOC107082923	arg2	ENSCVAP00000016968	ENSCVAP00000018249	Arginase.	Arginase.	0.902