(85 nodes) Positive regulation of T cell activation network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vsir	V-set immunoregulatory receptor. (296 aa)
	nck2	Cytoplasmic protein. (395 aa)
	sash3	SAM and SH3 domain containing 3. (392 aa)
	Nfkbid	ANK_REP_REGION domain-containing protein. (330 aa)
	ENSCVAP00000005090	Uncharacterized protein. (404 aa)
	LOC107101479	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (256 aa)
	ENSCVAP00000005581	TNFR-Cys domain-containing protein. (102 aa)
	ENSCVAP00000005673	Ig-like domain-containing protein. (125 aa)
	cd276	CD276 molecule. (298 aa)
	ENSCVAP00000006093	TNFR-Cys domain-containing protein. (259 aa)
	ENSCVAP00000006510	Ig-like domain-containing protein. (210 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	ENSCVAP00000007169	MHC_II_beta domain-containing protein. (106 aa)
	LOC107082207	Ig-like domain-containing protein. (218 aa)
	LOC107082226	Ig-like domain-containing protein. (242 aa)
	LOC107099636	Amine oxidase. (520 aa)
	LOC107082239	Ig-like domain-containing protein. (253 aa)
	LOC107089263	CD40 ligand; Belongs to the tumor necrosis factor family. (240 aa)
	LOC107082582	Si:dkey-175m17.7. (879 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (771 aa)
	LOC107101899	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (267 aa)
	ENSCVAP00000008226	Uncharacterized protein. (641 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	LOC107097723	Tyrosine-protein kinase. (600 aa)
	LOC107099564	Galectin. (135 aa)
	LOC107099565	Galectin. (135 aa)
	LOC107088704	Uncharacterized protein. (468 aa)
	ENSCVAP00000010507	TNFR-Cys domain-containing protein. (232 aa)
	LOC107103603	Uncharacterized protein. (343 aa)
	LOC107099476	Interleukin-1. (247 aa)
	LOC107084171	Fibronectin type-III domain-containing protein. (323 aa)
	bad	BCL2 associated agonist of cell death b. (163 aa)
	efnb3	Ephrin-B3a; Belongs to the ephrin family. (342 aa)
	ENSCVAP00000014531	NACHT domain-containing protein. (800 aa)
	xbp1	X-box binding protein 1. (261 aa)
	nck1	Cytoplasmic protein. (394 aa)
	LOC107099835	Ig-like domain-containing protein. (249 aa)
	ENSCVAP00000016571	Uncharacterized protein. (698 aa)
	cd83	Ig-like domain-containing protein. (225 aa)
	LOC107087925	Solute carrier family 7 member 1a. (650 aa)
	efnb1	Ephrin-B1; Belongs to the ephrin family. (336 aa)
	nfkbiz	ANK_REP_REGION domain-containing protein. (387 aa)
	abl1	Tyrosine-protein kinase. (1115 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	LOC107093348	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	ENSCVAP00000020184	Ig-like domain-containing protein. (201 aa)
	syk	Tyrosine-protein kinase. (623 aa)
	LOC107089487	Insulin-like growth factor 2b. (214 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (388 aa)
	card11	Uncharacterized protein. (1160 aa)
	hspd1	Heat shock 60 protein 1; Belongs to the chaperonin (HSP60) family. (575 aa)
	ENSCVAP00000022214	Ig-like domain-containing protein. (244 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	LOC107082220	Ig-like domain-containing protein. (260 aa)
	ENSCVAP00000024677	Uncharacterized protein. (291 aa)
	LOC107104423	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (824 aa)
	ENSCVAP00000025230	KRAP_IP3R_bind domain-containing protein. (510 aa)
	il6st	Uncharacterized protein. (885 aa)
	LOC107099584	Interleukin 12 receptor, beta 2a. (814 aa)
	ENSCVAP00000026045	HERV-H LTR-associating 2a, tandem duplicate 2. (488 aa)
	LOC107089243	ZP domain-containing protein. (421 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (966 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (272 aa)
	malt1	MALT paracaspase 1. (826 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1374 aa)
	LOC107099909	MALT paracaspase 3. (689 aa)
	ENSCVAP00000029458	Uncharacterized protein. (353 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (460 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (671 aa)
	SLC7A1	Solute carrier family 7 member 1. (644 aa)
	cbfb	Core-binding factor subunit beta. (188 aa)
	gata3	GATA binding protein 3. (441 aa)
	ENSCVAP00000032222	Pyrin domain-containing protein. (914 aa)
	abl2	Tyrosine-protein kinase. (1189 aa)
	ENSCVAP00000000476	Uncharacterized protein. (259 aa)
	ENSCVAP00000000478	Uncharacterized protein. (244 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (594 aa)
	LOC107097310	MALT paracaspase 2. (808 aa)
	lef1	Lymphoid enhancer-binding factor 1. (378 aa)
	LOC107103272	Uncharacterized protein. (207 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	LOC107095718	SCY domain-containing protein. (110 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	LOC107099476	ENSCVAP00000024393	ENSCVAP00000011289	Allograft inflammatory factor 1.	Interleukin-1.	0.602
AIF1	PTPRC	ENSCVAP00000024393	ENSCVAP00000027357	Allograft inflammatory factor 1.	Protein tyrosine phosphatase receptor type C.	0.472
ENSCVAP00000005581	LOC107089263	ENSCVAP00000005581	ENSCVAP00000007364	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.687
ENSCVAP00000005581	LOC107101479	ENSCVAP00000005581	ENSCVAP00000005311	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.888
ENSCVAP00000005581	LOC107101899	ENSCVAP00000005581	ENSCVAP00000008225	TNFR-Cys domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.722
ENSCVAP00000005673	LOC107089263	ENSCVAP00000005673	ENSCVAP00000007364	Ig-like domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.469
ENSCVAP00000005673	vtcn1	ENSCVAP00000005673	ENSCVAP00000028068	Ig-like domain-containing protein.	V-set domain containing T cell activation inhibitor 1.	0.439
ENSCVAP00000006093	LOC107089263	ENSCVAP00000006093	ENSCVAP00000007364	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.687
ENSCVAP00000006093	LOC107101479	ENSCVAP00000006093	ENSCVAP00000005311	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.988
ENSCVAP00000006093	LOC107101899	ENSCVAP00000006093	ENSCVAP00000008225	TNFR-Cys domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.722
ENSCVAP00000006510	LOC107082207	ENSCVAP00000006510	ENSCVAP00000007223	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.408
ENSCVAP00000006510	LOC107082220	ENSCVAP00000006510	ENSCVAP00000024653	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.911
ENSCVAP00000006510	LOC107082226	ENSCVAP00000006510	ENSCVAP00000007238	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.898
ENSCVAP00000006510	LOC107082239	ENSCVAP00000006510	ENSCVAP00000007270	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.408
ENSCVAP00000006510	PTPRC	ENSCVAP00000006510	ENSCVAP00000027357	Ig-like domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.407
ENSCVAP00000007169	LOC107082220	ENSCVAP00000007169	ENSCVAP00000024653	MHC_II_beta domain-containing protein.	Ig-like domain-containing protein.	0.873
ENSCVAP00000007169	LOC107082226	ENSCVAP00000007169	ENSCVAP00000007238	MHC_II_beta domain-containing protein.	Ig-like domain-containing protein.	0.873
ENSCVAP00000007169	PTPRC	ENSCVAP00000007169	ENSCVAP00000027357	MHC_II_beta domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.407
ENSCVAP00000010507	LOC107089263	ENSCVAP00000010507	ENSCVAP00000007364	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.687
ENSCVAP00000010507	LOC107101479	ENSCVAP00000010507	ENSCVAP00000005311	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.988