(21 nodes) Regulation of cardiac muscle contraction network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107092036	Gap junction alpha-5 protein-like. (377 aa)
	LOC107085877	ANK_REP_REGION domain-containing protein. (1099 aa)
	pkd2	Polycystic kidney disease 2. (888 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (618 aa)
	ankrd28	Ankyrin repeat domain 28b. (898 aa)
	LOC107086597	Grancalcin. (234 aa)
	LOC107103021	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (377 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	pln	Si:ch211-270g19.5. (53 aa)
	ENSCVAP00000003289	Ion_trans domain-containing protein; Belongs to the potassium channel family. (314 aa)
	LOC107102670	Si:dkey-206d17.12. (600 aa)
	LOC107093348	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC107093336	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
	LOC107099668	ANK_REP_REGION domain-containing protein. (1045 aa)
	ankrd52	Ankyrin repeat domain 52a. (1077 aa)
	LOC107085142	Ring finger protein 207a. (409 aa)
	LOC107090777	Junction plakoglobin a. (724 aa)
	LOC107084711	Zinc finger CCCH-type containing 12A. (619 aa)
	ucn	Urotensin 1. (144 aa)
	LOC107095979	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (350 aa)
	LOC107099470	Sorcin. (116 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107090777	LOC107093336	ENSCVAP00000030699	ENSCVAP00000019963	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
LOC107090777	LOC107093348	ENSCVAP00000030699	ENSCVAP00000019962	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.510
LOC107090777	cav1	ENSCVAP00000030699	ENSCVAP00000007154	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
LOC107093336	LOC107090777	ENSCVAP00000019963	ENSCVAP00000030699	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.460
LOC107093336	LOC107093348	ENSCVAP00000019963	ENSCVAP00000019962	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.581
LOC107093348	LOC107090777	ENSCVAP00000019962	ENSCVAP00000030699	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.510
LOC107093348	LOC107093336	ENSCVAP00000019962	ENSCVAP00000019963	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.581
LOC107093348	cav1	ENSCVAP00000019962	ENSCVAP00000007154	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.562
cav1	LOC107090777	ENSCVAP00000007154	ENSCVAP00000030699	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.460
cav1	LOC107093348	ENSCVAP00000007154	ENSCVAP00000019962	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.562