(58 nodes) Regulation of pathway-restricted SMAD protein phosphorylation network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	smad7	Mothers against decapentaplegic homolog. (366 aa)
	RBPMS	RNA binding protein, mRNA processing factor. (194 aa)
	INHBB	Inhibin subunit beta B. (389 aa)
	ENSCVAP00000010749	Nodal-related 1. (155 aa)
	bmp7	Bone morphogenetic protein 7b. (427 aa)
	inha	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (342 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1052 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	LOC107098322	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
	LOC107100813	Growth differentiation factor 11. (388 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	LOC107084459	Mothers against decapentaplegic homolog. (516 aa)
	LOC107095130	TGF_BETA_2 domain-containing protein. (379 aa)
	LOC107102021	Bone morphogenetic protein 7a. (426 aa)
	LOC107096868	Bone morphogenetic protein 16. (476 aa)
	LOC107095675	Lefty1. (357 aa)
	acvr1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (718 aa)
	LOC107098545	Bone morphogenetic protein 6. (428 aa)
	bmp10	Bone morphogenetic protein 10. (487 aa)
	ENSCVAP00000000853	Elastin microfibril interfacer 1b. (871 aa)
	dab2	DAB adaptor protein 2. (767 aa)
	Pin1	Peptidyl-prolyl cis-trans isomerase. (153 aa)
	LOC107093036	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
	dkk1	Dickkopf WNT signaling pathway inhibitor 1a. (261 aa)
	bmp5	Bone morphogenetic protein 5. (457 aa)
	bmp8a	Bone morphogenetic protein 8a. (433 aa)
	LOC107088435	Bone morphogenetic protein 10, like. (462 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (400 aa)
	ldlrad4	Low density lipoprotein receptor class A domain containing 4b. (294 aa)
	INHBC	Inhibin subunit beta C. (384 aa)
	LOC107104447	Inhibin subunit beta Aa. (445 aa)
	LOC107097790	Mothers against decapentaplegic homolog. (500 aa)
	LOC107104398	Myostatin b. (377 aa)
	LOC107103685	Southpaw. (407 aa)
	LOC107080995	Inhibin subunit beta Ab. (130 aa)
	LOC107091520	Bone morphogenetic protein 15. (434 aa)
	LOC107101535	Growth differentiation factor 10b. (441 aa)
	LOC107095682	Elastin microfibril interfacer 1a. (1022 aa)
	LOC107086617	TGF_BETA_2 domain-containing protein. (507 aa)
	nodal	Nodal-related 2. (378 aa)
	mstn	Myostatin a. (369 aa)
	gdf6	Growth differentiation factor 6a. (414 aa)
	smad6	Mothers against decapentaplegic homolog. (492 aa)
	ENSCVAP00000021102	MH2 domain-containing protein. (204 aa)
	LOC107096250	Growth differentiation factor 2. (421 aa)
	ENSCVAP00000020195	Growth differentiation factor 3. (374 aa)
	bmp4	Bone morphogenetic protein 4. (399 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	LOC107083120	Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
	LOC107103972	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (739 aa)
	LOC107086786	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	LOC107088450	Mothers against decapentaplegic homolog. (503 aa)
	bmp3	Bone morphogenetic protein 3. (463 aa)
	snx25	Sorting nexin 25. (972 aa)
	bmper	BMP binding endothelial regulator. (589 aa)
	gdf5	Growth differentiation factor 5. (552 aa)
	GREM1	Gremlin. (184 aa)
	LOC107103470	Inhibin subunit beta B. (392 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000010749	ENSCVAP00000020195	ENSCVAP00000010749	ENSCVAP00000020195	Nodal-related 1.	Growth differentiation factor 3.	0.771
ENSCVAP00000010749	INHBB	ENSCVAP00000010749	ENSCVAP00000011394	Nodal-related 1.	Inhibin subunit beta B.	0.901
ENSCVAP00000010749	INHBC	ENSCVAP00000010749	ENSCVAP00000024767	Nodal-related 1.	Inhibin subunit beta C.	0.902
ENSCVAP00000010749	LOC107080995	ENSCVAP00000010749	ENSCVAP00000026387	Nodal-related 1.	Inhibin subunit beta Ab.	0.901
ENSCVAP00000010749	LOC107095675	ENSCVAP00000010749	ENSCVAP00000003127	Nodal-related 1.	Lefty1.	0.957
ENSCVAP00000010749	LOC107103470	ENSCVAP00000010749	ENSCVAP00000014780	Nodal-related 1.	Inhibin subunit beta B.	0.901
ENSCVAP00000010749	LOC107103685	ENSCVAP00000010749	ENSCVAP00000025485	Nodal-related 1.	Southpaw.	0.901
ENSCVAP00000010749	LOC107104447	ENSCVAP00000010749	ENSCVAP00000024891	Nodal-related 1.	Inhibin subunit beta Aa.	0.901
ENSCVAP00000010749	nodal	ENSCVAP00000010749	ENSCVAP00000023302	Nodal-related 1.	Nodal-related 2.	0.901
ENSCVAP00000020195	ENSCVAP00000010749	ENSCVAP00000020195	ENSCVAP00000010749	Growth differentiation factor 3.	Nodal-related 1.	0.771
ENSCVAP00000020195	LOC107095675	ENSCVAP00000020195	ENSCVAP00000003127	Growth differentiation factor 3.	Lefty1.	0.441
ENSCVAP00000020195	LOC107103685	ENSCVAP00000020195	ENSCVAP00000025485	Growth differentiation factor 3.	Southpaw.	0.561
ENSCVAP00000020195	nodal	ENSCVAP00000020195	ENSCVAP00000023302	Growth differentiation factor 3.	Nodal-related 2.	0.561
ENSCVAP00000021102	INHBB	ENSCVAP00000021102	ENSCVAP00000011394	MH2 domain-containing protein.	Inhibin subunit beta B.	0.467
ENSCVAP00000021102	LOC107080995	ENSCVAP00000021102	ENSCVAP00000026387	MH2 domain-containing protein.	Inhibin subunit beta Ab.	0.467
ENSCVAP00000021102	LOC107086786	ENSCVAP00000021102	ENSCVAP00000018653	MH2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.549
ENSCVAP00000021102	LOC107093036	ENSCVAP00000021102	ENSCVAP00000029250	MH2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.549
ENSCVAP00000021102	LOC107096868	ENSCVAP00000021102	ENSCVAP00000003931	MH2 domain-containing protein.	Bone morphogenetic protein 16.	0.696
ENSCVAP00000021102	LOC107097790	ENSCVAP00000021102	ENSCVAP00000025040	MH2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.483
ENSCVAP00000021102	LOC107098322	ENSCVAP00000021102	ENSCVAP00000006318	MH2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.624