(34 nodes) Protein K63-linked ubiquitination network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107092296	RING-type domain-containing protein. (312 aa)
	ENSCVAP00000031935	Uncharacterized protein. (62 aa)
	LOC107090723	Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
	LOC107103455	E3 ubiquitin-protein ligase. (866 aa)
	ENSCVAP00000029008	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	LOC107098762	E3 ubiquitin-protein ligase. (725 aa)
	LOC107098764	E3 ubiquitin-protein ligase. (806 aa)
	LOC107088677	Im:7152348. (152 aa)
	Hectd1	HECT domain-containing protein. (170 aa)
	ENSCVAP00000023462	Uncharacterized protein. (194 aa)
	LOC107103559	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	RNF126	Ring finger protein 126. (315 aa)
	rnf4	RING-type domain-containing protein. (191 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (668 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
	traf3ip2	SEFIR domain-containing protein. (290 aa)
	rnf115	Ring finger protein 115. (315 aa)
	LOC107094197	Si:ch211-113e8.10. (769 aa)
	LOC107084043	Si:ch211-81a5.1. (296 aa)
	ube2g1	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast). (89 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (515 aa)
	rnf168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (426 aa)
	LOC107104226	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	BFAR	Bifunctional apoptosis regulator. (457 aa)
	prpf19	Pre-mRNA processing factor 19. (505 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	ENSCVAP00000007456	Uncharacterized protein. (158 aa)
	Park2	RBR-type E3 ubiquitin transferase. (71 aa)
	rnf152	Ring finger protein 152. (172 aa)
	LOC107103870	TNF receptor-associated factor. (428 aa)
	LOC107094607	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	LOC107092860	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (597 aa)
	LOC107095771	TRAF3 interacting protein 2-like. (439 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	ENSCVAP00000029008	ENSCVAP00000012346	ENSCVAP00000029008	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 2.	0.445
BFAR	ENSCVAP00000031935	ENSCVAP00000012346	ENSCVAP00000031935	Bifunctional apoptosis regulator.	Uncharacterized protein.	0.445
BFAR	LOC107090723	ENSCVAP00000012346	ENSCVAP00000031618	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 1.	0.464
BFAR	rnf8	ENSCVAP00000012346	ENSCVAP00000021481	Bifunctional apoptosis regulator.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.517
ENSCVAP00000007456	ENSCVAP00000029008	ENSCVAP00000007456	ENSCVAP00000029008	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 variant 2.	0.594
ENSCVAP00000007456	ENSCVAP00000031935	ENSCVAP00000007456	ENSCVAP00000031935	Uncharacterized protein.	Uncharacterized protein.	0.589
ENSCVAP00000007456	LOC107090723	ENSCVAP00000007456	ENSCVAP00000031618	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 variant 1.	0.964
ENSCVAP00000007456	LOC107094607	ENSCVAP00000007456	ENSCVAP00000001617	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.804
ENSCVAP00000007456	LOC107103559	ENSCVAP00000007456	ENSCVAP00000023217	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.	0.804
ENSCVAP00000007456	LOC107104226	ENSCVAP00000007456	ENSCVAP00000013359	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.595
ENSCVAP00000007456	ube2g1	ENSCVAP00000007456	ENSCVAP00000014835	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast).	0.595
ENSCVAP00000023462	Hectd1	ENSCVAP00000023462	ENSCVAP00000023478	Uncharacterized protein.	HECT domain-containing protein.	0.919
ENSCVAP00000029008	BFAR	ENSCVAP00000029008	ENSCVAP00000012346	Ubiquitin-conjugating enzyme E2 variant 2.	Bifunctional apoptosis regulator.	0.445
ENSCVAP00000029008	ENSCVAP00000007456	ENSCVAP00000029008	ENSCVAP00000007456	Ubiquitin-conjugating enzyme E2 variant 2.	Uncharacterized protein.	0.594
ENSCVAP00000029008	LOC107090723	ENSCVAP00000029008	ENSCVAP00000031618	Ubiquitin-conjugating enzyme E2 variant 2.	Ubiquitin-conjugating enzyme E2 variant 1.	0.574
ENSCVAP00000029008	LOC107092860	ENSCVAP00000029008	ENSCVAP00000001591	Ubiquitin-conjugating enzyme E2 variant 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.419
ENSCVAP00000029008	LOC107094607	ENSCVAP00000029008	ENSCVAP00000001617	Ubiquitin-conjugating enzyme E2 variant 2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.978
ENSCVAP00000029008	LOC107103559	ENSCVAP00000029008	ENSCVAP00000023217	Ubiquitin-conjugating enzyme E2 variant 2.	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.	0.978
ENSCVAP00000029008	LOC107103870	ENSCVAP00000029008	ENSCVAP00000002344	Ubiquitin-conjugating enzyme E2 variant 2.	TNF receptor-associated factor.	0.419
ENSCVAP00000029008	LOC107104226	ENSCVAP00000029008	ENSCVAP00000013359	Ubiquitin-conjugating enzyme E2 variant 2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.830