(103 nodes) Regulation of leukocyte proliferation network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tmem131l	Transmembrane 131 like. (1510 aa)
	LOC107099405	Uncharacterized protein. (265 aa)
	LOC107099407	Uncharacterized protein. (290 aa)
	LOC107091426	Galectin. (372 aa)
	nck1	Cytoplasmic protein. (394 aa)
	GREM1	Gremlin. (184 aa)
	Tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (213 aa)
	LOC107082923	Arginase. (354 aa)
	LOC107087925	Solute carrier family 7 member 1a. (650 aa)
	LOC107090721	CCAAT enhancer binding protein beta. (287 aa)
	LOC107101650	Uncharacterized protein. (270 aa)
	arg2	Arginase. (348 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	ENSCVAP00000019920	Uncharacterized protein. (514 aa)
	ENSCVAP00000020184	Ig-like domain-containing protein. (201 aa)
	syk	Tyrosine-protein kinase. (623 aa)
	LOC107089487	Insulin-like growth factor 2b. (214 aa)
	card11	Uncharacterized protein. (1160 aa)
	LOC107082770	Neuromedin B. (135 aa)
	IRF1	Interferon regulatory factor. (300 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (621 aa)
	tmem147	Transmembrane protein 147. (225 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (718 aa)
	sh3rf1	SH3 domain containing ring finger 1. (844 aa)
	ENSCVAP00000023439	Son of sevenless homolog 1 (Drosophila). (608 aa)
	nf1	Neurofibromin 1b. (2729 aa)
	LOC107085442	Uncharacterized protein. (274 aa)
	tyrobp	Uncharacterized protein. (108 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1127 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (622 aa)
	ENSCVAP00000024677	Uncharacterized protein. (291 aa)
	LOC107104423	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (824 aa)
	il6st	Uncharacterized protein. (885 aa)
	LOC107097753	IGv domain-containing protein. (243 aa)
	LOC107099584	Interleukin 12 receptor, beta 2a. (814 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (897 aa)
	ENSCVAP00000026045	HERV-H LTR-associating 2a, tandem duplicate 2. (488 aa)
	LOC107089243	ZP domain-containing protein. (421 aa)
	ENSCVAP00000026250	TNFR-Cys domain-containing protein. (385 aa)
	ENSCVAP00000026747	Galectin. (348 aa)
	ENSCVAP00000026802	Galectin. (294 aa)
	LOC107097439	Galectin. (327 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (966 aa)
	nmbr	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (397 aa)
	tnfrsf13b	TACI-CRD2 domain-containing protein. (260 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (759 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (272 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1112 aa)
	LOC107094188	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2022 aa)
	LOC107098764	E3 ubiquitin-protein ligase. (806 aa)
	ENSCVAP00000032883	Uncharacterized protein. (111 aa)
	LOC107091800	Signal transducer and activator of transcription. (787 aa)
	ocstamp	Osteoclast stimulatory transmembrane protein. (468 aa)
	SLC7A1	Solute carrier family 7 member 1. (644 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (460 aa)
	LOC107103455	E3 ubiquitin-protein ligase. (866 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (346 aa)
	LOC107098762	E3 ubiquitin-protein ligase. (725 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	vsir	V-set immunoregulatory receptor. (296 aa)
	crtam	Ig-like domain-containing protein. (430 aa)
	ENSCVAP00000000476	Uncharacterized protein. (259 aa)
	ENSCVAP00000000478	Uncharacterized protein. (244 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	LOC107091169	ATPase family AAA domain containing 5a. (1526 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (684 aa)
	il4r	Uncharacterized protein. (701 aa)
	LOC107095718	SCY domain-containing protein. (110 aa)
	LOC107103272	Uncharacterized protein. (207 aa)
	nck2	Cytoplasmic protein. (395 aa)
	LOC107083927	Tumor necrosis factor receptor superfamily, member 9a. (289 aa)
	il10	Interleukin 10. (184 aa)
	Glmn	Uncharacterized protein. (111 aa)
	RASSF5	Ras association domain family member 5. (270 aa)
	LOC107095156	Signal transducer and activator of transcription. (726 aa)
	sash3	SAM and SH3 domain containing 3. (392 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1325 aa)
	LOC107087694	Pentaxin. (235 aa)
	LOC107087693	Pentraxin fusion protein-like. (235 aa)
	LOC107096044	Galectin. (247 aa)
	ENSCVAP00000005581	TNFR-Cys domain-containing protein. (102 aa)
	ENSCVAP00000005673	Ig-like domain-containing protein. (125 aa)
	cd276	CD276 molecule. (298 aa)
	ENSCVAP00000006093	TNFR-Cys domain-containing protein. (259 aa)
	LOC107099636	Amine oxidase. (520 aa)
	LOC107087640	Signal transducer and activator of transcription. (785 aa)
	LOC107089263	CD40 ligand; Belongs to the tumor necrosis factor family. (240 aa)
	LOC107081155	Pentaxin. (216 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	il34	Interleukin 34. (221 aa)
	LOC107097723	Tyrosine-protein kinase. (600 aa)
	LOC107083714	CD40 molecule, TNF receptor superfamily member 5. (300 aa)
	LOC107090375	Uncharacterized protein. (271 aa)
	LOC107088704	Uncharacterized protein. (468 aa)
	ENSCVAP00000010481	Galectin. (123 aa)
	ENSCVAP00000010507	TNFR-Cys domain-containing protein. (232 aa)
	LOC107103603	Uncharacterized protein. (343 aa)
	LOC107093061	Leucine rich repeat containing 32. (747 aa)
	LOC107099476	Interleukin-1. (247 aa)
	ENSCVAP00000011755	TAN domain-containing protein. (119 aa)
	Atm	Uncharacterized protein. (145 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	LOC107099476	ENSCVAP00000024393	ENSCVAP00000011289	Allograft inflammatory factor 1.	Interleukin-1.	0.602
AIF1	PTPRC	ENSCVAP00000024393	ENSCVAP00000027357	Allograft inflammatory factor 1.	Protein tyrosine phosphatase receptor type C.	0.472
AIF1	il10	ENSCVAP00000024393	ENSCVAP00000003674	Allograft inflammatory factor 1.	Interleukin 10.	0.426
AIF1	tyrobp	ENSCVAP00000024393	ENSCVAP00000024283	Allograft inflammatory factor 1.	Uncharacterized protein.	0.892
Atm	ENSCVAP00000011755	ENSCVAP00000011758	ENSCVAP00000011755	Uncharacterized protein.	TAN domain-containing protein.	0.922
Atm	LOC107091169	ENSCVAP00000011758	ENSCVAP00000001775	Uncharacterized protein.	ATPase family AAA domain containing 5a.	0.584
Atm	nf1	ENSCVAP00000011758	ENSCVAP00000023910	Uncharacterized protein.	Neurofibromin 1b.	0.401
ENSCVAP00000005581	LOC107089263	ENSCVAP00000005581	ENSCVAP00000007364	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.687
ENSCVAP00000005673	LOC107083927	ENSCVAP00000005673	ENSCVAP00000003255	Ig-like domain-containing protein.	Tumor necrosis factor receptor superfamily, member 9a.	0.449
ENSCVAP00000005673	LOC107089263	ENSCVAP00000005673	ENSCVAP00000007364	Ig-like domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.469
ENSCVAP00000005673	LOC107097753	ENSCVAP00000005673	ENSCVAP00000025345	Ig-like domain-containing protein.	IGv domain-containing protein.	0.546
ENSCVAP00000005673	vtcn1	ENSCVAP00000005673	ENSCVAP00000028068	Ig-like domain-containing protein.	V-set domain containing T cell activation inhibitor 1.	0.439
ENSCVAP00000006093	LOC107089263	ENSCVAP00000006093	ENSCVAP00000007364	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.687
ENSCVAP00000010481	PTPRC	ENSCVAP00000010481	ENSCVAP00000027357	Galectin.	Protein tyrosine phosphatase receptor type C.	0.432
ENSCVAP00000010507	LOC107089263	ENSCVAP00000010507	ENSCVAP00000007364	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.687
ENSCVAP00000011755	Atm	ENSCVAP00000011755	ENSCVAP00000011758	TAN domain-containing protein.	Uncharacterized protein.	0.922
ENSCVAP00000011755	LOC107091169	ENSCVAP00000011755	ENSCVAP00000001775	TAN domain-containing protein.	ATPase family AAA domain containing 5a.	0.584
ENSCVAP00000011755	nf1	ENSCVAP00000011755	ENSCVAP00000023910	TAN domain-containing protein.	Neurofibromin 1b.	0.401
ENSCVAP00000019920	LOC107103699	ENSCVAP00000019920	ENSCVAP00000008432	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.860
ENSCVAP00000020184	LOC107097753	ENSCVAP00000020184	ENSCVAP00000025345	Ig-like domain-containing protein.	IGv domain-containing protein.	0.423