(50 nodes) Regulation of neurotransmitter receptor activity network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107092595	Discs, large (Drosophila) homolog-associated protein 3. (960 aa)
	neto2	Neuropilin (NRP) and tolloid (TLL)-like 2b. (612 aa)
	dlgap1	Discs, large (Drosophila) homolog-associated protein 1b. (1011 aa)
	LOC107105132	Discs, large (Drosophila) homolog-associated protein 2b. (981 aa)
	LOC107086142	Proline-rich transmembrane protein 1. (241 aa)
	LOC107087157	Neuronal pentraxin receptor a. (536 aa)
	SHISA6	Shisa family member 6. (498 aa)
	LOC107082755	Uncharacterized protein. (1164 aa)
	ENSCVAP00000002687	Si:ch73-343g19.4. (95 aa)
	LOC107100306	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (341 aa)
	nptx1	Uncharacterized protein. (423 aa)
	pink1	PTEN induced kinase 1. (472 aa)
	homer3	Homer scaffold protein 3b. (366 aa)
	cacng2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (317 aa)
	LOC107092340	Uncharacterized protein. (303 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	LOC107098884	Homer scaffold protein 1b. (358 aa)
	LOC107102942	Discs, large (Drosophila) homolog-associated protein 4b. (1110 aa)
	LOC107097594	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (324 aa)
	LOC107097593	Neuronal pentraxin 2a. (436 aa)
	cacng5	Calcium channel, voltage-dependent, gamma subunit 5a. (277 aa)
	LOC107094833	Uncharacterized protein. (1089 aa)
	LOC107080725	Gsg1-like. (178 aa)
	shank1	SH3 and multiple ankyrin repeat domains 1. (838 aa)
	LOC107095972	Uncharacterized protein. (314 aa)
	rasgrf1	Ras protein specific guanine nucleotide releasing factor 1. (1170 aa)
	crh	Corticotropin releasing hormone b. (176 aa)
	CNIH2	Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
	ENSCVAP00000015734	WH1 domain-containing protein. (226 aa)
	LOC107089094	Uncharacterized protein. (294 aa)
	klhl24	Kelch-like family member 24a. (596 aa)
	LOC107086234	Shisa family member 9a. (384 aa)
	ENSCVAP00000018274	Uncharacterized protein. (252 aa)
	LOC107089007	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (373 aa)
	LOC107089012	Shisa family member 7. (678 aa)
	cacng3	Calcium voltage-gated channel auxiliary subunit gamma 3. (317 aa)
	LOC107087158	Uncharacterized protein. (383 aa)
	RELN	Reelin. (3062 aa)
	nptxr	Neuronal pentraxin receptor b. (594 aa)
	LOC107091675	Neuropilin (NRP) and tolloid (TLL)-like 1. (580 aa)
	LOC107088784	Shisa family member 7a. (703 aa)
	dlgap2	Discs, large (Drosophila) homolog-associated protein 2a. (1026 aa)
	LOC107089236	Neuropilin (NRP) and tolloid (TLL)-like 2b. (556 aa)
	shank3	SH3 and multiple ankyrin repeat domains 3a. (1586 aa)
	cacng4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (333 aa)
	ENSCVAP00000028554	Uncharacterized protein. (606 aa)
	LOC107083073	Shisa family member 9b. (378 aa)
	LOC107095392	Cornichon family AMPA receptor auxiliary protein 3. (174 aa)
	LOC107092533	Calcium channel, voltage-dependent, gamma subunit 5b. (276 aa)
	LOC107089538	Uncharacterized protein. (1695 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000015734	LOC107089538	ENSCVAP00000015734	ENSCVAP00000032588	WH1 domain-containing protein.	Uncharacterized protein.	0.505
ENSCVAP00000015734	LOC107098884	ENSCVAP00000015734	ENSCVAP00000010839	WH1 domain-containing protein.	Homer scaffold protein 1b.	0.871
ENSCVAP00000015734	shank1	ENSCVAP00000015734	ENSCVAP00000013612	WH1 domain-containing protein.	SH3 and multiple ankyrin repeat domains 1.	0.505
ENSCVAP00000015734	shank3	ENSCVAP00000015734	ENSCVAP00000026135	WH1 domain-containing protein.	SH3 and multiple ankyrin repeat domains 3a.	0.505
ENSCVAP00000018274	LOC107089538	ENSCVAP00000018274	ENSCVAP00000032588	Uncharacterized protein.	Uncharacterized protein.	0.764
ENSCVAP00000018274	LOC107092595	ENSCVAP00000018274	ENSCVAP00000011908	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 3.	0.443
ENSCVAP00000018274	shank1	ENSCVAP00000018274	ENSCVAP00000013612	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 1.	0.764
ENSCVAP00000018274	shank3	ENSCVAP00000018274	ENSCVAP00000026135	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 3a.	0.764
ENSCVAP00000028554	LOC107092595	ENSCVAP00000028554	ENSCVAP00000011908	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 3.	0.428
LOC107089012	shank3	ENSCVAP00000018808	ENSCVAP00000026135	Shisa family member 7.	SH3 and multiple ankyrin repeat domains 3a.	0.406
LOC107089538	ENSCVAP00000015734	ENSCVAP00000032588	ENSCVAP00000015734	Uncharacterized protein.	WH1 domain-containing protein.	0.505
LOC107089538	ENSCVAP00000018274	ENSCVAP00000032588	ENSCVAP00000018274	Uncharacterized protein.	Uncharacterized protein.	0.764
LOC107089538	LOC107092595	ENSCVAP00000032588	ENSCVAP00000011908	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 3.	0.824
LOC107089538	LOC107094833	ENSCVAP00000032588	ENSCVAP00000013264	Uncharacterized protein.	Uncharacterized protein.	0.754
LOC107089538	LOC107098884	ENSCVAP00000032588	ENSCVAP00000010839	Uncharacterized protein.	Homer scaffold protein 1b.	0.647
LOC107089538	LOC107102942	ENSCVAP00000032588	ENSCVAP00000011402	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 4b.	0.754
LOC107089538	LOC107105132	ENSCVAP00000032588	ENSCVAP00000001805	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 2b.	0.778
LOC107089538	dlgap1	ENSCVAP00000032588	ENSCVAP00000001678	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 1b.	0.778
LOC107089538	dlgap2	ENSCVAP00000032588	ENSCVAP00000024983	Uncharacterized protein.	Discs, large (Drosophila) homolog-associated protein 2a.	0.747
LOC107089538	homer3	ENSCVAP00000032588	ENSCVAP00000008598	Uncharacterized protein.	Homer scaffold protein 3b.	0.505