(16 nodes) Clathrin-coated endocytic vesicle network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107104663	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
	ENSCVAP00000014430	Uncharacterized protein. (114 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	LOC107103921	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (948 aa)
	LOC107091770	Si:dkey-16l2.16. (209 aa)
	LOC107101473	Alpha_adaptinC2 domain-containing protein. (841 aa)
	LOC107101887	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	rab35	RAB35, member RAS oncogene family b. (201 aa)
	epn2	Epsin 2. (579 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1690 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
	lmbrd1	LMBR1 domain containing 1. (494 aa)
	ENSCVAP00000012437	Solute carrier family 18 member 3a. (515 aa)
	LOC107089997	Solute carrier family 18 member A3. (518 aa)
	inpp5f	Inositol polyphosphate-5-phosphatase F. (1139 aa)
	LOC107082218	Epsin 1. (644 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000012437	LOC107101473	ENSCVAP00000012437	ENSCVAP00000023523	Solute carrier family 18 member 3a.	Alpha_adaptinC2 domain-containing protein.	0.496
ENSCVAP00000014430	LOC107082218	ENSCVAP00000014430	ENSCVAP00000000330	Uncharacterized protein.	Epsin 1.	0.743
ENSCVAP00000014430	LOC107101473	ENSCVAP00000014430	ENSCVAP00000023523	Uncharacterized protein.	Alpha_adaptinC2 domain-containing protein.	0.722
ENSCVAP00000014430	LOC107103921	ENSCVAP00000014430	ENSCVAP00000021034	Uncharacterized protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.876
ENSCVAP00000014430	ap2m1	ENSCVAP00000014430	ENSCVAP00000031359	Uncharacterized protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.849
ENSCVAP00000014430	ap2s1	ENSCVAP00000014430	ENSCVAP00000017307	Uncharacterized protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.832
ENSCVAP00000014430	epn2	ENSCVAP00000014430	ENSCVAP00000028037	Uncharacterized protein.	Epsin 2.	0.828
LOC107082218	ENSCVAP00000014430	ENSCVAP00000000330	ENSCVAP00000014430	Epsin 1.	Uncharacterized protein.	0.743
LOC107082218	LOC107101473	ENSCVAP00000000330	ENSCVAP00000023523	Epsin 1.	Alpha_adaptinC2 domain-containing protein.	0.628
LOC107082218	LOC107101887	ENSCVAP00000000330	ENSCVAP00000025415	Epsin 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.743
LOC107082218	LOC107103921	ENSCVAP00000000330	ENSCVAP00000021034	Epsin 1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.807
LOC107082218	LOC107104663	ENSCVAP00000000330	ENSCVAP00000014297	Epsin 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.743
LOC107082218	ap2m1	ENSCVAP00000000330	ENSCVAP00000031359	Epsin 1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.658
LOC107082218	ap2s1	ENSCVAP00000000330	ENSCVAP00000017307	Epsin 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.601
LOC107082218	cltcl1	ENSCVAP00000000330	ENSCVAP00000030298	Epsin 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.743
LOC107089997	LOC107101473	ENSCVAP00000005909	ENSCVAP00000023523	Solute carrier family 18 member A3.	Alpha_adaptinC2 domain-containing protein.	0.496
LOC107091770	rab35	ENSCVAP00000021460	ENSCVAP00000026893	Si:dkey-16l2.16.	RAB35, member RAS oncogene family b.	0.901
LOC107101473	ENSCVAP00000012437	ENSCVAP00000023523	ENSCVAP00000012437	Alpha_adaptinC2 domain-containing protein.	Solute carrier family 18 member 3a.	0.496
LOC107101473	ENSCVAP00000014430	ENSCVAP00000023523	ENSCVAP00000014430	Alpha_adaptinC2 domain-containing protein.	Uncharacterized protein.	0.722
LOC107101473	LOC107082218	ENSCVAP00000023523	ENSCVAP00000000330	Alpha_adaptinC2 domain-containing protein.	Epsin 1.	0.628