(26 nodes) Kringle-like fold network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	habp2	Uncharacterized protein. (642 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (950 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
	LOC107082737	Uncharacterized protein. (1435 aa)
	mrc1	Mannose receptor, C type 1a. (1435 aa)
	LOC107085972	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
	LOC107101847	Uncharacterized protein. (454 aa)
	LOC107099956	Mannose receptor, C type 1b. (1190 aa)
	LOC107082546	Lymphocyte antigen 75. (1730 aa)
	hgfac	HGF activator. (590 aa)
	plg	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (799 aa)
	kremen1	Kringle containing transmembrane protein 1. (474 aa)
	prss12	Serine protease 12; Belongs to the peptidase S1 family. (829 aa)
	mmp2	Matrix metallopeptidase 2. (657 aa)
	LOC107088994	Si:ch73-127m5.1; Belongs to the peptidase S1 family. (908 aa)
	pik3ip1	Phosphoinositide-3-kinase interacting protein 1. (301 aa)
	plau	Uncharacterized protein; Belongs to the peptidase S1 family. (386 aa)
	mst1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (727 aa)
	LOC107092660	Fibronectin 1a. (2499 aa)
	LOC107082542	Fibronectin 1b. (2414 aa)
	ENSCVAP00000025549	Uncharacterized protein. (179 aa)
	mmp9	Matrix metallopeptidase 9. (691 aa)
	pla2r1	Phospholipase A2 receptor 1. (1488 aa)
	igf2r	Insulin-like growth factor 2 receptor. (2382 aa)
	plat	Plasminogen activator, tissue. (608 aa)
	sel1l	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (814 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000025549	hgfac	ENSCVAP00000025549	ENSCVAP00000013849	Uncharacterized protein.	HGF activator.	0.662
LOC107085972	hgfac	ENSCVAP00000008410	ENSCVAP00000013849	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	HGF activator.	0.661
LOC107101847	plg	ENSCVAP00000009720	ENSCVAP00000014136	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.751
f2	habp2	ENSCVAP00000003097	ENSCVAP00000029658	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.447
f2	hgfac	ENSCVAP00000003097	ENSCVAP00000013849	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	HGF activator.	0.608
f2	mmp9	ENSCVAP00000003097	ENSCVAP00000027042	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Matrix metallopeptidase 9.	0.405
f2	plg	ENSCVAP00000003097	ENSCVAP00000014136	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.921
habp2	f2	ENSCVAP00000029658	ENSCVAP00000003097	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.447
habp2	hgfac	ENSCVAP00000029658	ENSCVAP00000013849	Uncharacterized protein.	HGF activator.	0.444
habp2	plg	ENSCVAP00000029658	ENSCVAP00000014136	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.487
hgfac	ENSCVAP00000025549	ENSCVAP00000013849	ENSCVAP00000025549	HGF activator.	Uncharacterized protein.	0.662
hgfac	LOC107085972	ENSCVAP00000013849	ENSCVAP00000008410	HGF activator.	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.661
hgfac	f2	ENSCVAP00000013849	ENSCVAP00000003097	HGF activator.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.608
hgfac	habp2	ENSCVAP00000013849	ENSCVAP00000029658	HGF activator.	Uncharacterized protein.	0.444
hgfac	mst1	ENSCVAP00000013849	ENSCVAP00000023119	HGF activator.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.663
hgfac	plg	ENSCVAP00000013849	ENSCVAP00000014136	HGF activator.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.559
mmp2	mmp9	ENSCVAP00000015552	ENSCVAP00000027042	Matrix metallopeptidase 2.	Matrix metallopeptidase 9.	0.498
mmp2	plg	ENSCVAP00000015552	ENSCVAP00000014136	Matrix metallopeptidase 2.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.552
mmp9	f2	ENSCVAP00000027042	ENSCVAP00000003097	Matrix metallopeptidase 9.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.405
mmp9	mmp2	ENSCVAP00000027042	ENSCVAP00000015552	Matrix metallopeptidase 9.	Matrix metallopeptidase 2.	0.498