(34 nodes) Protein kinase, C-terminal network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107081812	Ribosomal protein S6 kinase. (762 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	LOC107084094	Ribosomal protein S6 kinase. (746 aa)
	LOC107091383	Ribosomal protein S6 kinase. (782 aa)
	stk38	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
	LOC107102671	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (422 aa)
	LOC107090628	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (762 aa)
	cdc42bpa	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1806 aa)
	prkcd	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
	prkce	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (554 aa)
	LOC107093922	Protein kinase N3. (863 aa)
	stk38l	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (463 aa)
	ENSCVAP00000008285	AGC-kinase C-terminal domain-containing protein. (60 aa)
	LOC107103040	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa)
	LOC107091507	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (700 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC107096319	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (498 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	LOC107087452	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
	LOC107086424	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	LOC107099926	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	sgk3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
	LOC107083482	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	LOC107092514	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	ENSCVAP00000018542	AGC-kinase C-terminal domain-containing protein. (60 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC107095820	Ribosomal protein S6 kinase. (803 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
	sgk2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (361 aa)
	LOC107096074	Ribosomal protein S6 kinase. (727 aa)
	LOC107087681	Protein kinase N1b. (963 aa)
	rps6kb2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
	LOC107088073	Ribosomal protein S6 kinase. (779 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107081812	sgk3	ENSCVAP00000028913	ENSCVAP00000015099	Ribosomal protein S6 kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.400
LOC107083482	LOC107087452	ENSCVAP00000015997	ENSCVAP00000012044	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.603
LOC107083482	LOC107096319	ENSCVAP00000015997	ENSCVAP00000011589	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.603
LOC107083482	LOC107102671	ENSCVAP00000015997	ENSCVAP00000000577	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.572
LOC107083482	SGK1	ENSCVAP00000015997	ENSCVAP00000000513	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.572
LOC107083482	rps6kb2	ENSCVAP00000015997	ENSCVAP00000026202	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.605
LOC107083482	sgk2	ENSCVAP00000015997	ENSCVAP00000020440	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.571
LOC107083482	sgk3	ENSCVAP00000015997	ENSCVAP00000015099	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.495
LOC107084094	LOC107088073	ENSCVAP00000030622	ENSCVAP00000028346	Ribosomal protein S6 kinase.	Ribosomal protein S6 kinase.	0.429
LOC107084094	sgk3	ENSCVAP00000030622	ENSCVAP00000015099	Ribosomal protein S6 kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.400
LOC107086424	PRKCB	ENSCVAP00000013469	ENSCVAP00000018815	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
LOC107086424	prkci	ENSCVAP00000013469	ENSCVAP00000030195	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.442
LOC107087452	LOC107083482	ENSCVAP00000012044	ENSCVAP00000015997	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.603
LOC107087452	LOC107096319	ENSCVAP00000012044	ENSCVAP00000011589	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.900
LOC107087452	LOC107099926	ENSCVAP00000012044	ENSCVAP00000014231	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.602
LOC107087452	akt1	ENSCVAP00000012044	ENSCVAP00000011154	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.602
LOC107088073	LOC107084094	ENSCVAP00000028346	ENSCVAP00000030622	Ribosomal protein S6 kinase.	Ribosomal protein S6 kinase.	0.429
LOC107088073	sgk3	ENSCVAP00000028346	ENSCVAP00000015099	Ribosomal protein S6 kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.400
LOC107090628	LOC107091507	ENSCVAP00000001704	ENSCVAP00000011129	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.422
LOC107090628	prkcd	ENSCVAP00000001704	ENSCVAP00000003980	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.420