(38 nodes) PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	plce1	Phospholipase C, epsilon 1. (2292 aa)
	LOC107097449	PLCXc domain-containing protein. (308 aa)
	ENSCVAP00000000589	Uncharacterized protein. (336 aa)
	LOC107105118	Phosphoinositide phospholipase C. (747 aa)
	LOC107094094	Phosphatidylinositol-specific phospholipase C, X domain containing 2. (323 aa)
	LOC107089343	Phosphoinositide phospholipase C. (1132 aa)
	plch1	Phosphoinositide phospholipase C. (1690 aa)
	ENSCVAP00000006817	Glycerophosphodiester phosphodiesterase domain containing 1. (139 aa)
	LOC107098647	Phosphoinositide phospholipase C. (814 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1310 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1190 aa)
	LOC107084767	Phosphoinositide phospholipase C. (792 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
	PLCB4	Phosphoinositide phospholipase C. (971 aa)
	LOC107102950	Si:dkey-266f7.9. (326 aa)
	LOC107095401	Phosphatidylinositol-specific phospholipase C, X domain containing 1. (317 aa)
	LOC107095416	Si:dkey-66a8.7. (330 aa)
	plcb3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1221 aa)
	plcl2	Phosphoinositide phospholipase C. (1109 aa)
	plch2	Phosphoinositide phospholipase C. (1398 aa)
	LOC107083412	Glycerophosphodiester phosphodiesterase 1. (309 aa)
	ENSCVAP00000021450	Phosphoinositide phospholipase C. (938 aa)
	LOC107092730	Phosphoinositide phospholipase C. (532 aa)
	LOC107104800	Phosphoinositide phospholipase C. (772 aa)
	PLCD3	Phosphoinositide phospholipase C. (733 aa)
	gdpd4	Glycerophosphodiester phosphodiesterase domain containing 4a. (452 aa)
	LOC107084377	Phosphoinositide phospholipase C. (1115 aa)
	plcxd3	Phosphatidylinositol-specific phospholipase C, X domain containing 3. (324 aa)
	gpcpd1	Glycerophosphocholine phosphodiesterase 1. (672 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
	LOC107097015	Phosphoinositide phospholipase C. (847 aa)
	LOC107101179	Glycerophosphodiester phosphodiesterase domain containing 3a. (315 aa)
	LOC107083024	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1306 aa)
	gdpd2	Glycerophosphodiester phosphodiesterase domain containing 2. (518 aa)
	LOC107083498	Glycerophosphodiester phosphodiesterase domain containing 5b. (589 aa)
	ENSCVAP00000032499	Uncharacterized protein. (90 aa)
	plcd4	Phosphoinositide phospholipase C. (734 aa)
	LOC107091794	Phosphoinositide phospholipase C. (1212 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000000589	LOC107102950	ENSCVAP00000000589	ENSCVAP00000011180	Uncharacterized protein.	Si:dkey-266f7.9.	0.914
ENSCVAP00000021450	PLCB4	ENSCVAP00000021450	ENSCVAP00000011166	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.458
LOC107083024	LOC107084767	ENSCVAP00000029330	ENSCVAP00000010741	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.748
LOC107083024	LOC107089343	ENSCVAP00000029330	ENSCVAP00000005222	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.440
LOC107083024	LOC107097015	ENSCVAP00000029330	ENSCVAP00000028285	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.748
LOC107083024	LOC107098647	ENSCVAP00000029330	ENSCVAP00000007985	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.675
LOC107083024	LOC107104800	ENSCVAP00000029330	ENSCVAP00000023166	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.748
LOC107083024	PLCB1	ENSCVAP00000029330	ENSCVAP00000027171	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.675
LOC107083024	PLCB2	ENSCVAP00000029330	ENSCVAP00000010937	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.675
LOC107083024	plcb3	ENSCVAP00000029330	ENSCVAP00000013729	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.675
LOC107083024	plcd4	ENSCVAP00000029330	ENSCVAP00000032529	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.748
LOC107083024	plce1	ENSCVAP00000029330	ENSCVAP00000032458	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phospholipase C, epsilon 1.	0.814
LOC107083024	plcg1	ENSCVAP00000029330	ENSCVAP00000008343	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.901
LOC107083024	plch1	ENSCVAP00000029330	ENSCVAP00000005622	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.490
LOC107083024	plch2	ENSCVAP00000029330	ENSCVAP00000018139	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide phospholipase C.	0.440
LOC107084767	LOC107083024	ENSCVAP00000010741	ENSCVAP00000029330	Phosphoinositide phospholipase C.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.748
LOC107084767	LOC107089343	ENSCVAP00000010741	ENSCVAP00000005222	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.413
LOC107084767	LOC107097015	ENSCVAP00000010741	ENSCVAP00000028285	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.695
LOC107084767	LOC107098647	ENSCVAP00000010741	ENSCVAP00000007985	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.726
LOC107084767	LOC107104800	ENSCVAP00000010741	ENSCVAP00000023166	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.695