STRINGSTRING
fyn fyn LOC107095820 LOC107095820 NTRK3 NTRK3 LOC107089581 LOC107089581 ap2s1 ap2s1 clta clta LOC107102211 LOC107102211 egr1 egr1 fndc3b fndc3b LOC107088576 LOC107088576 LOC107096452 LOC107096452 ppp4r1 ppp4r1 creb1 creb1 mapk1 mapk1 ppp4r4 ppp4r4 srf srf LOC107084657 LOC107084657 map2k2 map2k2 bdnf bdnf rapgef1 rapgef1 LOC107097242 LOC107097242 LOC107101186 LOC107101186 LOC107084710 LOC107084710 ENSCVAP00000012583 ENSCVAP00000012583 crk crk LOC107096025 LOC107096025 LOC107085894 LOC107085894 LOC107096572 LOC107096572 LOC107101279 LOC107101279 LOC107090404 LOC107090404 LOC107087504 LOC107087504 LOC107084246 LOC107084246 pik3ca pik3ca SRC SRC LOC107101302 LOC107101302 plcg1 plcg1 LOC107087023 LOC107087023 hras hras ntf3 ntf3 ENSCVAP00000007008 ENSCVAP00000007008 dusp6 dusp6 ENSCVAP00000006854 ENSCVAP00000006854 LOC107101432 LOC107101432 ID2 ID2 ntrk2 ntrk2 dusp3 dusp3 nab1 nab1 KRAS KRAS map2k1 map2k1 LOC107095138 LOC107095138 MAPKAPK3 MAPKAPK3 furin furin LOC107102019 LOC107102019 MAPKAPK2 MAPKAPK2 relch relch LOC107095712 LOC107095712 LOC107096191 LOC107096191 fnbp4 fnbp4 dock3 dock3 LOC107095805 LOC107095805 pcsk5 pcsk5 LOC107082069 LOC107082069 SGK1 SGK1 CSDE1 CSDE1 LOC107104997 LOC107104997 LOC107103921 LOC107103921 LOC107086130 LOC107086130 LOC107095687 LOC107095687 sh3gl2 sh3gl2 mapk7 mapk7 dnal4 dnal4 pik3cb pik3cb LOC107088346 LOC107088346 LOC107082632 LOC107082632 LOC107101473 LOC107101473 LOC107087652 LOC107087652 LOC107086777 LOC107086777 ENSCVAP00000024183 ENSCVAP00000024183 LOC107081852 LOC107081852 egr2 egr2 PIK3CA PIK3CA nkpd1 nkpd1 map2k5 map2k5 vrk3 vrk3 JUND JUND ralgds ralgds LOC107096611 LOC107096611 frs2 frs2 LOC107088171 LOC107088171 crkl crkl trib2 trib2 LOC107095444 LOC107095444 BAX BAX LOC107090293 LOC107090293 id3 id3 LOC107088073 LOC107088073 LOC107103198 LOC107103198 LOC107097013 LOC107097013 Ascl1 Ascl1 LOC107099411 LOC107099411 irs2 irs2 SHC3 SHC3 ppp2r1b ppp2r1b fndc3a fndc3a fosl1 fosl1 LOC107091383 LOC107091383 ntrk3 ntrk3 shc2 shc2 LOC107084094 LOC107084094 ap2m1 ap2m1 ntrk1 ntrk1 mapk15 mapk15 LOC107092482 LOC107092482 ppp2ca ppp2ca ENSCVAP00000032850 ENSCVAP00000032850 ENSCVAP00000020580 ENSCVAP00000020580 chd4 chd4 LOC107088991 LOC107088991
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fynTyrosine-protein kinase. (537 aa)
LOC107095820Ribosomal protein S6 kinase. (803 aa)
NTRK3Tyrosine-protein kinase receptor. (773 aa)
LOC107089581Kinase D-interacting substrate 220b. (1649 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
LOC107102211Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
fndc3bFibronectin type III domain containing 3Ba. (1207 aa)
LOC107088576Mitogen-activated protein kinase. (364 aa)
LOC107096452JunD proto-oncogene, AP-1 transcription factor subunit. (274 aa)
ppp4r1WRNPLPNID domain-containing protein. (975 aa)
creb1cAMP responsive element binding protein 1a. (331 aa)
mapk1Mitogen-activated protein kinase. (351 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (749 aa)
srfMADS-box domain-containing protein. (596 aa)
LOC107084657Serine/threonine-protein phosphatase. (309 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (293 aa)
rapgef1Rap guanine nucleotide exchange factor (GEF) 1b. (1217 aa)
LOC107097242NGF domain-containing protein; Belongs to the NGF-beta family. (419 aa)
LOC107101186Mitogen-activated protein kinase. (379 aa)
LOC107084710ANK_REP_REGION domain-containing protein. (1622 aa)
ENSCVAP00000012583Uncharacterized protein. (58 aa)
crkCRK proto-oncogene, adaptor protein. (310 aa)
LOC107096025Uncharacterized protein. (201 aa)
LOC107085894Serine/threonine-protein phosphatase. (309 aa)
LOC107096572SH3 domain containing GRB2 like 2a, endophilin A1. (363 aa)
LOC107101279Mitogen-activated protein kinase 11. (293 aa)
LOC107090404Uncharacterized protein; Belongs to the DOCK family. (1942 aa)
LOC107087504Mitogen-activated protein kinase. (357 aa)
LOC107084246cAMP responsive element binding protein 1. (313 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1004 aa)
SRCTyrosine-protein kinase. (551 aa)
LOC107101302Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (197 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1310 aa)
LOC107087023Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (287 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (302 aa)
ENSCVAP00000007008Achaete-scute family bHLH transcription factor 1b. (176 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
ENSCVAP00000006854Si:dkey-23i12.7. (109 aa)
LOC107101432Mitogen-activated protein kinase. (360 aa)
ID2Inhibitor of DNA binding 2. (143 aa)
ntrk2Tyrosine-protein kinase receptor. (672 aa)
dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
nab1NGFI-A binding protein 1a (EGR1 binding protein 1). (503 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
LOC107095138Zgc:55558. (187 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (403 aa)
furinFurin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (841 aa)
LOC107102019Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
MAPKAPK2MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (319 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1212 aa)
LOC107095712Inhibitor of DNA binding 4. (148 aa)
LOC107096191Tyrosine-protein kinase. (537 aa)
fnbp4Formin binding protein 4. (878 aa)
dock3Uncharacterized protein; Belongs to the DOCK family. (1901 aa)
LOC107095805Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (810 aa)
pcsk5Proprotein convertase subtilisin/kexin type 5b; Belongs to the peptidase S8 family. (1145 aa)
LOC107082069Activating transcription factor 1. (311 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (907 aa)
LOC107104997Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (218 aa)
LOC107103921AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (948 aa)
LOC107086130Chromodomain helicase DNA binding protein 4a. (1942 aa)
LOC107095687BHLH domain-containing protein. (453 aa)
sh3gl2Uncharacterized protein. (351 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1095 aa)
dnal4Dynein light chain. (106 aa)
pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
LOC107088346Uncharacterized protein. (315 aa)
LOC107082632MADS-box domain-containing protein. (489 aa)
LOC107101473Alpha_adaptinC2 domain-containing protein. (841 aa)
LOC107087652JunB proto-oncogene, AP-1 transcription factor subunit b. (329 aa)
LOC107086777Insulin receptor substrate 2a. (1061 aa)
ENSCVAP00000024183BZIP domain-containing protein. (122 aa)
LOC107081852Uncharacterized protein. (318 aa)
egr2Early growth response 2b. (428 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1038 aa)
nkpd1NTPase, KAP family P-loop domain containing 1. (715 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (415 aa)
vrk3VRK serine/threonine kinase 3. (511 aa)
JUNDBZIP domain-containing protein. (296 aa)
ralgdsRal guanine nucleotide dissociation stimulator. (852 aa)
LOC107096611JunB proto-oncogene, AP-1 transcription factor subunit a. (328 aa)
frs2Fibroblast growth factor receptor substrate 2b. (531 aa)
LOC107088171Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (308 aa)
trib2Tribbles pseudokinase 2. (344 aa)
LOC107095444V-ral simian leukemia viral oncogene homolog Ba (ras related). (207 aa)
BAXBCL2 associated X, apoptosis regulator. (191 aa)
LOC107090293AP complex subunit beta. (919 aa)
id3Inhibitor of DNA binding 3. (116 aa)
LOC107088073Ribosomal protein S6 kinase. (779 aa)
LOC107103198Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
LOC107097013ETS transcription factor ELK1. (547 aa)
Ascl1Achaete-scute family bHLH transcription factor 1a. (164 aa)
LOC107099411V-ral simian leukemia viral oncogene homolog Aa (ras related). (206 aa)
irs2Insulin receptor substrate 2b. (1114 aa)
SHC3SHC adaptor protein 3. (664 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (589 aa)
fndc3aFibronectin type III domain containing 3A. (1234 aa)
fosl1FOS-like antigen 1a. (336 aa)
LOC107091383Ribosomal protein S6 kinase. (782 aa)
ntrk3Tyrosine-protein kinase receptor. (810 aa)
shc2SHC (Src homology 2 domain containing) transforming protein 2. (715 aa)
LOC107084094Ribosomal protein S6 kinase. (746 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
ntrk1Tyrosine-protein kinase receptor. (609 aa)
mapk15Mitogen-activated protein kinase. (601 aa)
LOC107092482Tribbles pseudokinase 1. (473 aa)
ppp2caSerine/threonine-protein phosphatase. (314 aa)
ENSCVAP00000032850Tyrosine-protein kinase receptor. (744 aa)
ENSCVAP00000020580GF_recep_IV domain-containing protein. (346 aa)
chd4Uncharacterized protein. (1787 aa)
LOC107088991Proprotein convertase subtilisin/kexin type 5a. (1083 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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