19 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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protein homology

Your Input:
	Terf2	Uncharacterized protein. (95 aa)
	rpa3	Replication protein A3. (122 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	LOC107092444	Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
	lig1	DNA ligase. (1004 aa)
	ENSCVAP00000010205	Uncharacterized protein. (338 aa)
	LOC107088102	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
	rpa2	Replication protein A2. (278 aa)
	LOC107099910	BLM RecQ like helicase. (1091 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	ENSCVAP00000016466	Uncharacterized protein. (164 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
	pold1	DNA polymerase. (1105 aa)
	LOC107089962	Zgc:110269. (342 aa)
	Pot1	Telo_bind domain-containing protein. (332 aa)
	tinf2	TERF1 (TRF1)-interacting nuclear factor 2. (561 aa)
	dna2	DNA replication helicase/nuclease 2. (1358 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000010205	ENSCVAP00000016466	ENSCVAP00000010205	ENSCVAP00000016466	Uncharacterized protein.	Uncharacterized protein.	0.403
ENSCVAP00000010205	LOC107088102	ENSCVAP00000010205	ENSCVAP00000011210	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.468
ENSCVAP00000010205	LOC107092444	ENSCVAP00000010205	ENSCVAP00000008412	Uncharacterized protein.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.462
ENSCVAP00000010205	LOC107099910	ENSCVAP00000010205	ENSCVAP00000014694	Uncharacterized protein.	BLM RecQ like helicase.	0.471
ENSCVAP00000010205	Pot1	ENSCVAP00000010205	ENSCVAP00000025139	Uncharacterized protein.	Telo_bind domain-containing protein.	0.965
ENSCVAP00000010205	Terf2	ENSCVAP00000010205	ENSCVAP00000010091	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSCVAP00000010205	dna2	ENSCVAP00000010205	ENSCVAP00000025528	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.484
ENSCVAP00000010205	pcna	ENSCVAP00000010205	ENSCVAP00000002844	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.621
ENSCVAP00000010205	pold1	ENSCVAP00000010205	ENSCVAP00000023009	Uncharacterized protein.	DNA polymerase.	0.543
ENSCVAP00000010205	rpa1	ENSCVAP00000010205	ENSCVAP00000016427	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.468
ENSCVAP00000010205	rpa2	ENSCVAP00000010205	ENSCVAP00000014581	Uncharacterized protein.	Replication protein A2.	0.403
ENSCVAP00000010205	tinf2	ENSCVAP00000010205	ENSCVAP00000025227	Uncharacterized protein.	TERF1 (TRF1)-interacting nuclear factor 2.	0.969
ENSCVAP00000016466	ENSCVAP00000010205	ENSCVAP00000016466	ENSCVAP00000010205	Uncharacterized protein.	Uncharacterized protein.	0.403
ENSCVAP00000016466	LOC107088102	ENSCVAP00000016466	ENSCVAP00000011210	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.884
ENSCVAP00000016466	LOC107089962	ENSCVAP00000016466	ENSCVAP00000024388	Uncharacterized protein.	Zgc:110269.	0.652
ENSCVAP00000016466	LOC107092444	ENSCVAP00000016466	ENSCVAP00000008412	Uncharacterized protein.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.488
ENSCVAP00000016466	LOC107099910	ENSCVAP00000016466	ENSCVAP00000014694	Uncharacterized protein.	BLM RecQ like helicase.	0.795
ENSCVAP00000016466	Pot1	ENSCVAP00000016466	ENSCVAP00000025139	Uncharacterized protein.	Telo_bind domain-containing protein.	0.493
ENSCVAP00000016466	dna2	ENSCVAP00000016466	ENSCVAP00000025528	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.811
ENSCVAP00000016466	fen1	ENSCVAP00000016466	ENSCVAP00000020740	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.652