STRINGSTRING
pola1 pola1 rpa3 rpa3 cdk2 cdk2 gar1 gar1 pcna pcna trub1 trub1 terf1 terf1 dkc1 dkc1 LOC107092444 LOC107092444 lig1 lig1 Terf2 Terf2 ENSCVAP00000010205 ENSCVAP00000010205 ankrd28 ankrd28 LOC107088102 LOC107088102 nop10 nop10 prim1 prim1 LOC107093706 LOC107093706 chtf8 chtf8 wrap53 wrap53 PPP6C PPP6C rpa2 rpa2 LOC107099910 LOC107099910 ruvbl2 ruvbl2 LOC107095354 LOC107095354 rpa1 rpa1 ENSCVAP00000016466 ENSCVAP00000016466 stn1 stn1 dscc1 dscc1 rfc4 rfc4 prim2 prim2 rtel1 rtel1 pold4 pold4 ENSCVAP00000019055 ENSCVAP00000019055 rfc2 rfc2 ENSCVAP00000019159 ENSCVAP00000019159 LOC107100955 LOC107100955 fen1 fen1 nhp2 nhp2 pold2 pold2 RCBTB1 RCBTB1 pold1 pold1 LOC107099668 LOC107099668 rfc1 rfc1 LOC107093923 LOC107093923 recql4 recql4 LOC107089962 LOC107089962 Pot1 Pot1 ankrd52 ankrd52 tinf2 tinf2 dna2 dna2 pola2 pola2 ccna2 ccna2 rfc3 rfc3 LOC107085877 LOC107085877 ccna1 ccna1 ten1 ten1 tert tert chtf18 chtf18 exd2 exd2 rfc5 rfc5 shq1 shq1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pola1DNA polymerase. (1420 aa)
rpa3Replication protein A3. (122 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (209 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (326 aa)
terf1Telomeric repeat binding factor (NIMA-interacting) 1. (288 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (511 aa)
LOC107092444Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
lig1DNA ligase. (1004 aa)
Terf2Uncharacterized protein. (95 aa)
ENSCVAP00000010205Uncharacterized protein. (338 aa)
ankrd28Ankyrin repeat domain 28b. (898 aa)
LOC107088102Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa)
LOC107093706Uncharacterized protein. (421 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (131 aa)
wrap53WD repeat containing, antisense to TP53. (507 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
rpa2Replication protein A2. (278 aa)
LOC107099910BLM RecQ like helicase. (1091 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (495 aa)
LOC107095354Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
ENSCVAP00000016466Uncharacterized protein. (164 aa)
stn1STN1 subunit of CST complex. (350 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (505 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1170 aa)
pold4Si:dkey-28b4.7. (107 aa)
ENSCVAP00000019055Uncharacterized protein. (256 aa)
rfc2Replication factor C (activator 1) 2. (373 aa)
ENSCVAP00000019159Methionine sulfoxide reductase B1b. (252 aa)
LOC107100955Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (86 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (555 aa)
pold1DNA polymerase. (1105 aa)
LOC107099668ANK_REP_REGION domain-containing protein. (1045 aa)
rfc1Replication factor C subunit 1. (1159 aa)
LOC107093923Serine/threonine-protein phosphatase. (271 aa)
recql4RecQ helicase-like 4. (942 aa)
LOC107089962Zgc:110269. (342 aa)
Pot1Telo_bind domain-containing protein. (332 aa)
ankrd52Ankyrin repeat domain 52a. (1077 aa)
tinf2TERF1 (TRF1)-interacting nuclear factor 2. (561 aa)
dna2DNA replication helicase/nuclease 2. (1358 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (604 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC107085877ANK_REP_REGION domain-containing protein. (1099 aa)
ccna1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (389 aa)
ten1TEN1 subunit of CST complex. (139 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1091 aa)
chtf18AAA domain-containing protein. (920 aa)
exd2Exonuclease 3'-5' domain containing 2. (671 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (582 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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