65 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cilp2	Cartilage intermediate layer protein 2. (1196 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC107098852	Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (483 aa)
	LOC107101770	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (226 aa)
	gab2	GRB2-associated binding protein 2. (675 aa)
	ENSCVAP00000000999	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (167 aa)
	igf1r	Tyrosine-protein kinase receptor. (1416 aa)
	Fgf4	Fibroblast growth factor 4. (144 aa)
	LOC107093166	Tribbles pseudokinase 3. (350 aa)
	gab1	GRB2-associated binding protein 1. (766 aa)
	LOC107087110	Fibroblast growth factor receptor. (775 aa)
	LOC107087768	Si:ch73-335l21.1. (1267 aa)
	LOC107091522	Insulin receptor substrate 4a. (1343 aa)
	LOC107089165	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1004 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	lctl	Lactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
	LOC107091024	Uncharacterized protein. (1797 aa)
	Lct	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (530 aa)
	LOC107089939	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (172 aa)
	ENSCVAP00000008530	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (183 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	pik3cb	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	LOC107086777	Insulin receptor substrate 2a. (1061 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1038 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	ENSCVAP00000025630	Uncharacterized protein. (133 aa)
	LOC107088237	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	klb	Klotho beta. (1061 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (531 aa)
	kl	Klotho. (976 aa)
	LOC107084161	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	pde3b	Phosphodiesterase. (1099 aa)
	LOC107089396	PH domain-containing protein. (761 aa)
	ENSCVAP00000022018	Uncharacterized protein. (54 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (249 aa)
	LOC107089487	Insulin-like growth factor 2b. (214 aa)
	LOC107096308	Thioesterase superfamily member 4. (245 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (443 aa)
	LOC107090685	Fibroblast growth factor receptor 4. (944 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSCVAP00000018644	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	LOC107089793	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	LOC107081801	Fibroblast growth factor receptor. (831 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (276 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	cilp	Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase. (1160 aa)
	irs2	Insulin receptor substrate 2b. (1114 aa)
	fgfr2	Fibroblast growth factor receptor 2. (655 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (227 aa)
	LOC107096942	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	LOC107102211	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC107082377	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	LOC107083482	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	LOC107101656	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (160 aa)
	ENSCVAP00000014841	Uncharacterized protein. (76 aa)
	ENSCVAP00000014703	Fibroblast growth factor receptor 2. (372 aa)
	LOC107102306	Si:ch211-284e13.4. (1153 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000000999	LOC107081801	ENSCVAP00000000999	ENSCVAP00000028004	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.433
ENSCVAP00000000999	LOC107089396	ENSCVAP00000000999	ENSCVAP00000022161	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	PH domain-containing protein.	0.463
ENSCVAP00000000999	LOC107089793	ENSCVAP00000000999	ENSCVAP00000027854	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ENSCVAP00000000999	LOC107096942	ENSCVAP00000000999	ENSCVAP00000032467	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
ENSCVAP00000000999	LOC107101770	ENSCVAP00000000999	ENSCVAP00000011263	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.573
ENSCVAP00000000999	fgf10	ENSCVAP00000000999	ENSCVAP00000016952	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ENSCVAP00000000999	fgf22	ENSCVAP00000000999	ENSCVAP00000022903	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ENSCVAP00000000999	fgf23	ENSCVAP00000000999	ENSCVAP00000028227	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.590
ENSCVAP00000000999	fgf3	ENSCVAP00000000999	ENSCVAP00000021072	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.453
ENSCVAP00000000999	fgf5	ENSCVAP00000000999	ENSCVAP00000018007	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.466
ENSCVAP00000000999	fgf7	ENSCVAP00000000999	ENSCVAP00000025526	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.407
ENSCVAP00000000999	grb2	ENSCVAP00000000999	ENSCVAP00000009535	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.489
ENSCVAP00000008530	LOC107081801	ENSCVAP00000008530	ENSCVAP00000028004	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.433
ENSCVAP00000008530	LOC107089396	ENSCVAP00000008530	ENSCVAP00000022161	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	PH domain-containing protein.	0.463
ENSCVAP00000008530	LOC107089793	ENSCVAP00000008530	ENSCVAP00000027854	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.447
ENSCVAP00000008530	LOC107089939	ENSCVAP00000008530	ENSCVAP00000007289	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.428
ENSCVAP00000008530	LOC107096942	ENSCVAP00000008530	ENSCVAP00000032467	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
ENSCVAP00000008530	LOC107101656	ENSCVAP00000008530	ENSCVAP00000015898	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.427
ENSCVAP00000008530	LOC107101770	ENSCVAP00000008530	ENSCVAP00000011263	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.573
ENSCVAP00000008530	fgf10	ENSCVAP00000008530	ENSCVAP00000016952	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.460