19 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	LOC107084562	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (208 aa)
	ENSCVAP00000000718	ETS domain-containing protein. (171 aa)
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
	rps27a	Ribosomal protein S27a. (181 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (459 aa)
	ENSCVAP00000012362	ETS domain-containing protein. (164 aa)
	LOC107101186	Mitogen-activated protein kinase. (379 aa)
	mapk1	Mitogen-activated protein kinase. (351 aa)
	ets1	V-ets avian erythroblastosis virus E26 oncogene homolog 1. (485 aa)
	LOC107090181	ETS2 repressor factor. (621 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
	dusp13	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (192 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (351 aa)
	LOC107097873	Ets variant 2. (371 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	LOC107084055	ANK_REP_REGION domain-containing protein. (145 aa)
	ERF	Ets2 repressor factor like 3. (724 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
	LOC107093887	Inhibitor of DNA binding 1, HLH protein. (163 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000000718	LOC107093887	ENSCVAP00000000718	ENSCVAP00000024316	ETS domain-containing protein.	Inhibitor of DNA binding 1, HLH protein.	0.652
ENSCVAP00000000718	LOC107101186	ENSCVAP00000000718	ENSCVAP00000013006	ETS domain-containing protein.	Mitogen-activated protein kinase.	0.534
ENSCVAP00000000718	mapk1	ENSCVAP00000000718	ENSCVAP00000015363	ETS domain-containing protein.	Mitogen-activated protein kinase.	0.534
ENSCVAP00000000718	tp53	ENSCVAP00000000718	ENSCVAP00000022398	ETS domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.432
LOC107084055	cdk4	ENSCVAP00000029382	ENSCVAP00000000849	ANK_REP_REGION domain-containing protein.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.974
LOC107084055	cdk6	ENSCVAP00000029382	ENSCVAP00000027893	ANK_REP_REGION domain-containing protein.	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.974
LOC107093887	ENSCVAP00000000718	ENSCVAP00000024316	ENSCVAP00000000718	Inhibitor of DNA binding 1, HLH protein.	ETS domain-containing protein.	0.652
LOC107093887	LOC107097873	ENSCVAP00000024316	ENSCVAP00000023620	Inhibitor of DNA binding 1, HLH protein.	Ets variant 2.	0.652
LOC107093887	ets1	ENSCVAP00000024316	ENSCVAP00000016985	Inhibitor of DNA binding 1, HLH protein.	V-ets avian erythroblastosis virus E26 oncogene homolog 1.	0.652
LOC107097873	LOC107093887	ENSCVAP00000023620	ENSCVAP00000024316	Ets variant 2.	Inhibitor of DNA binding 1, HLH protein.	0.652
LOC107097873	LOC107101186	ENSCVAP00000023620	ENSCVAP00000013006	Ets variant 2.	Mitogen-activated protein kinase.	0.534
LOC107097873	mapk1	ENSCVAP00000023620	ENSCVAP00000015363	Ets variant 2.	Mitogen-activated protein kinase.	0.534
LOC107097873	tp53	ENSCVAP00000023620	ENSCVAP00000022398	Ets variant 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.432
LOC107101186	ENSCVAP00000000718	ENSCVAP00000013006	ENSCVAP00000000718	Mitogen-activated protein kinase.	ETS domain-containing protein.	0.534
LOC107101186	LOC107097873	ENSCVAP00000013006	ENSCVAP00000023620	Mitogen-activated protein kinase.	Ets variant 2.	0.534
LOC107101186	ets1	ENSCVAP00000013006	ENSCVAP00000016985	Mitogen-activated protein kinase.	V-ets avian erythroblastosis virus E26 oncogene homolog 1.	0.951
LOC107101186	mapk1	ENSCVAP00000013006	ENSCVAP00000015363	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.901
LOC107101186	tp53	ENSCVAP00000013006	ENSCVAP00000022398	Mitogen-activated protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.570
cdk4	LOC107084055	ENSCVAP00000000849	ENSCVAP00000029382	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	ANK_REP_REGION domain-containing protein.	0.974
cdk4	cdk6	ENSCVAP00000000849	ENSCVAP00000027893	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.907