36 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107092514	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	grip1	Glutamate receptor interacting protein 1. (1150 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
	LOC107086317	Glutamate receptor, ionotropic, AMPA 1a. (847 aa)
	LOC107090293	AP complex subunit beta. (919 aa)
	tspan7	Tetraspanin. (244 aa)
	cacng4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (333 aa)
	ENSCVAP00000027787	Uncharacterized protein. (99 aa)
	LOC107096604	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (478 aa)
	ENSCVAP00000026097	Uncharacterized protein. (69 aa)
	pick1	Protein interacting with prkca 1. (408 aa)
	LOC107101473	Alpha_adaptinC2 domain-containing protein. (841 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (482 aa)
	tspan6	Tetraspanin. (250 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (833 aa)
	LOC107103921	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (948 aa)
	LOC107093457	Glutamate ionotropic receptor AMPA type subunit 3. (882 aa)
	cacng3	Calcium voltage-gated channel auxiliary subunit gamma 3. (317 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	Gria3	Glutamate ionotropic receptor AMPA type subunit 3; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (284 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	LOC107081866	Uncharacterized protein. (832 aa)
	LOC107104585	Uncharacterized protein. (686 aa)
	LOC107086424	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	ENSCVAP00000012583	Uncharacterized protein. (58 aa)
	LOC107090284	Uncharacterized protein. (899 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	LOC107104319	Tetraspanin. (249 aa)
	grip2	Glutamate receptor interacting protein 2a. (900 aa)
	nsf	N-ethylmaleimide-sensitive factor a. (748 aa)
	cacng2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (317 aa)
	ENSCVAP00000008889	Phorbol-ester/DAG-type domain-containing protein. (56 aa)
	LOC107099602	Uncharacterized protein. (909 aa)
	LOC107100308	Protein kinase C. (776 aa)
	LOC107093238	N-ethylmaleimide-sensitive factor b. (746 aa)
	gria4	Glutamate receptor, ionotropic, AMPA 4a. (889 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000008889	pick1	ENSCVAP00000008889	ENSCVAP00000026020	Phorbol-ester/DAG-type domain-containing protein.	Protein interacting with prkca 1.	0.554
ENSCVAP00000012583	LOC107101473	ENSCVAP00000012583	ENSCVAP00000023523	Uncharacterized protein.	Alpha_adaptinC2 domain-containing protein.	0.887
ENSCVAP00000012583	LOC107103921	ENSCVAP00000012583	ENSCVAP00000021034	Uncharacterized protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.925
ENSCVAP00000012583	LOC107104585	ENSCVAP00000012583	ENSCVAP00000015838	Uncharacterized protein.	Uncharacterized protein.	0.418
ENSCVAP00000012583	ap2m1	ENSCVAP00000012583	ENSCVAP00000031359	Uncharacterized protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.949
ENSCVAP00000012583	ap2s1	ENSCVAP00000012583	ENSCVAP00000017307	Uncharacterized protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.947
ENSCVAP00000012583	grip2	ENSCVAP00000012583	ENSCVAP00000010384	Uncharacterized protein.	Glutamate receptor interacting protein 2a.	0.418
ENSCVAP00000026097	GRIA2	ENSCVAP00000026097	ENSCVAP00000022048	Uncharacterized protein.	Glutamate ionotropic receptor AMPA type subunit 2.	0.739
ENSCVAP00000026097	LOC107093238	ENSCVAP00000026097	ENSCVAP00000004705	Uncharacterized protein.	N-ethylmaleimide-sensitive factor b.	0.492
ENSCVAP00000026097	LOC107099602	ENSCVAP00000026097	ENSCVAP00000007954	Uncharacterized protein.	Uncharacterized protein.	0.739
ENSCVAP00000026097	ap2m1	ENSCVAP00000026097	ENSCVAP00000031359	Uncharacterized protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.415
ENSCVAP00000026097	cacng2	ENSCVAP00000026097	ENSCVAP00000009441	Uncharacterized protein.	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.474
ENSCVAP00000026097	cacng3	ENSCVAP00000026097	ENSCVAP00000018921	Uncharacterized protein.	Calcium voltage-gated channel auxiliary subunit gamma 3.	0.474
ENSCVAP00000026097	cacng4	ENSCVAP00000026097	ENSCVAP00000027798	Uncharacterized protein.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.474
ENSCVAP00000026097	grip1	ENSCVAP00000026097	ENSCVAP00000031361	Uncharacterized protein.	Glutamate receptor interacting protein 1.	0.666
ENSCVAP00000026097	nsf	ENSCVAP00000026097	ENSCVAP00000009839	Uncharacterized protein.	N-ethylmaleimide-sensitive factor a.	0.492
ENSCVAP00000026097	pick1	ENSCVAP00000026097	ENSCVAP00000026020	Uncharacterized protein.	Protein interacting with prkca 1.	0.658
ENSCVAP00000027787	GRIA2	ENSCVAP00000027787	ENSCVAP00000022048	Uncharacterized protein.	Glutamate ionotropic receptor AMPA type subunit 2.	0.739
ENSCVAP00000027787	LOC107093238	ENSCVAP00000027787	ENSCVAP00000004705	Uncharacterized protein.	N-ethylmaleimide-sensitive factor b.	0.492
ENSCVAP00000027787	LOC107099602	ENSCVAP00000027787	ENSCVAP00000007954	Uncharacterized protein.	Uncharacterized protein.	0.739