STRINGSTRING
rpa3 rpa3 LOC107091169 LOC107091169 pole2 pole2 pcna pcna LOC107092444 LOC107092444 lig1 lig1 pole pole LOC107088102 LOC107088102 rpa2 rpa2 LOC107095354 LOC107095354 polb polb pole4 pole4 rpa1 rpa1 ENSCVAP00000016466 ENSCVAP00000016466 rfc4 rfc4 pold4 pold4 apex2 apex2 ENSCVAP00000019055 ENSCVAP00000019055 rfc2 rfc2 ENSCVAP00000019159 ENSCVAP00000019159 LOC107100955 LOC107100955 pole3 pole3 fen1 fen1 pold2 pold2 RCBTB1 RCBTB1 pold1 pold1 rfc1 rfc1 LOC107089962 LOC107089962 rfc3 rfc3 rfc5 rfc5 apex1 apex1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpa3Replication protein A3. (122 aa)
LOC107091169ATPase family AAA domain containing 5a. (1526 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (529 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC107092444Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
lig1DNA ligase. (1004 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2017 aa)
LOC107088102Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
rpa2Replication protein A2. (278 aa)
LOC107095354Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (339 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
ENSCVAP00000016466Uncharacterized protein. (164 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
pold4Si:dkey-28b4.7. (107 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (572 aa)
ENSCVAP00000019055Uncharacterized protein. (256 aa)
rfc2Replication factor C (activator 1) 2. (373 aa)
ENSCVAP00000019159Methionine sulfoxide reductase B1b. (252 aa)
LOC107100955Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (555 aa)
pold1DNA polymerase. (1105 aa)
rfc1Replication factor C subunit 1. (1159 aa)
LOC107089962Zgc:110269. (342 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (310 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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