48 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107082377	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (907 aa)
	ENSCVAP00000000999	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (167 aa)
	Fgf4	Fibroblast growth factor 4. (144 aa)
	rps27a	Ribosomal protein S27a. (181 aa)
	LOC107095138	Zgc:55558. (187 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC107102581	Fibroblast growth factor receptor substrate 3. (607 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC107089939	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (172 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1310 aa)
	ENSCVAP00000008530	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (183 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	SRC	Tyrosine-protein kinase. (551 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1004 aa)
	LOC107089165	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC107101770	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (226 aa)
	LOC107085894	Serine/threonine-protein phosphatase. (309 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC107101186	Mitogen-activated protein kinase. (379 aa)
	LOC107098202	Uncharacterized protein. (860 aa)
	LOC107084657	Serine/threonine-protein phosphatase. (309 aa)
	mapk1	Mitogen-activated protein kinase. (351 aa)
	LOC107101656	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (160 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1207 aa)
	LOC107102211	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ENSCVAP00000018644	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (443 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (461 aa)
	ENSCVAP00000022018	Uncharacterized protein. (54 aa)
	LOC107089396	PH domain-containing protein. (761 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (952 aa)
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1038 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC107088237	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (531 aa)
	LOC107090307	Sprouty RTK signaling antagonist 2. (351 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (276 aa)
	LOC107083535	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (566 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1234 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (227 aa)
	LOC107096942	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (314 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	LOC107088237	ENSCVAP00000000427	ENSCVAP00000026069	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.460
CSDE1	LOC107089165	ENSCVAP00000000427	ENSCVAP00000010855	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.460
CSDE1	LOC107096942	ENSCVAP00000000427	ENSCVAP00000032467	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.462
CSDE1	LOC107101186	ENSCVAP00000000427	ENSCVAP00000013006	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.445
CSDE1	LOC107101770	ENSCVAP00000000427	ENSCVAP00000011263	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.441
CSDE1	LOC107102211	ENSCVAP00000000427	ENSCVAP00000016437	Cold shock domain containing E1, RNA-binding.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.524
CSDE1	LOC107102581	ENSCVAP00000000427	ENSCVAP00000006057	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.443
CSDE1	PIK3CA	ENSCVAP00000000427	ENSCVAP00000024569	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family.	0.524
CSDE1	fgf23	ENSCVAP00000000427	ENSCVAP00000028227	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.455
CSDE1	frs2	ENSCVAP00000000427	ENSCVAP00000026559	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.443
CSDE1	grb2	ENSCVAP00000000427	ENSCVAP00000009535	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.684
CSDE1	mapk1	ENSCVAP00000000427	ENSCVAP00000015363	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.445
CSDE1	pik3ca	ENSCVAP00000000427	ENSCVAP00000009741	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.524
CSDE1	ppp2r1b	ENSCVAP00000000427	ENSCVAP00000029761	Cold shock domain containing E1, RNA-binding.	Protein phosphatase 2, regulatory subunit A, beta b.	0.458
CSDE1	rps27a	ENSCVAP00000000427	ENSCVAP00000003612	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.494
CSDE1	shc1	ENSCVAP00000000427	ENSCVAP00000019790	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.465
CSDE1	uba52	ENSCVAP00000000427	ENSCVAP00000025559	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.504
ENSCVAP00000000999	LOC107089396	ENSCVAP00000000999	ENSCVAP00000022161	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	PH domain-containing protein.	0.463
ENSCVAP00000000999	LOC107096942	ENSCVAP00000000999	ENSCVAP00000032467	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
ENSCVAP00000000999	LOC107101770	ENSCVAP00000000999	ENSCVAP00000011263	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.573