STRINGSTRING
rad9a rad9a atr atr rfc5 rfc5 rad51 rad51 mre11 mre11 rad1 rad1 ankrd11 ankrd11 exd2 exd2 rad50 rad50 rfc3 rfc3 kat5 kat5 dna2 dna2 hus1 hus1 rmi1 rmi1 topbp1 topbp1 recql4 recql4 rmi2 rmi2 rhno1 rhno1 rad17 rad17 rpa2 rpa2 LOC107099910 LOC107099910 rad52 rad52 RCBTB1 RCBTB1 atrip atrip rpa3 rpa3 Ankrd12 Ankrd12 nbn nbn LOC107100955 LOC107100955 ENSCVAP00000019159 ENSCVAP00000019159 rfc2 rfc2 ENSCVAP00000019055 ENSCVAP00000019055 abl1 abl1 rfc4 rfc4 cdca7 cdca7 LOC107095354 LOC107095354 rpa1 rpa1 ENSCVAP00000016466 ENSCVAP00000016466 LOC107082497 LOC107082497 CDCA7L CDCA7L Atm Atm ENSCVAP00000011755 ENSCVAP00000011755 LOC107088102 LOC107088102 Rbbp8 Rbbp8 top3a top3a ENSCVAP00000006422 ENSCVAP00000006422 ENSCVAP00000005887 ENSCVAP00000005887 slf1 slf1 brca1 brca1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2502 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
ankrd11Ankyrin repeat domain 11. (2823 aa)
exd2Exonuclease 3'-5' domain containing 2. (671 aa)
rad50RAD50 homolog, double strand break repair protein. (1274 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa)
dna2DNA replication helicase/nuclease 2. (1358 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (643 aa)
topbp1DNA topoisomerase II binding protein 1. (1503 aa)
recql4RecQ helicase-like 4. (942 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
rhno1Si:ch73-352p4.5. (287 aa)
rad17RAD17 checkpoint clamp loader component. (493 aa)
rpa2Replication protein A2. (278 aa)
LOC107099910BLM RecQ like helicase. (1091 aa)
rad52RAD52 homolog, DNA repair protein. (374 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (555 aa)
atripUncharacterized protein. (773 aa)
rpa3Replication protein A3. (122 aa)
Ankrd12ANK_REP_REGION domain-containing protein. (438 aa)
nbnNibrin. (835 aa)
LOC107100955Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
ENSCVAP00000019159Methionine sulfoxide reductase B1b. (252 aa)
rfc2Replication factor C (activator 1) 2. (373 aa)
ENSCVAP00000019055Uncharacterized protein. (256 aa)
abl1Tyrosine-protein kinase. (1115 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
cdca7Cell division cycle associated 7a. (394 aa)
LOC107095354Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
ENSCVAP00000016466Uncharacterized protein. (164 aa)
LOC107082497Tudor domain containing 3. (759 aa)
CDCA7Lzf-4CXXC_R1 domain-containing protein. (405 aa)
AtmUncharacterized protein. (145 aa)
ENSCVAP00000011755TAN domain-containing protein. (119 aa)
LOC107088102Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
Rbbp8SAE2 domain-containing protein. (75 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1026 aa)
ENSCVAP00000006422Tudor domain containing 3. (116 aa)
ENSCVAP00000005887XPGI domain-containing protein. (618 aa)
slf1SMC5-SMC6 complex localization factor 1. (877 aa)
brca1Uncharacterized protein. (1314 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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