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| | LOC107088102 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa) |
| | LOC107090503 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSCVAP00000010146 | Tower domain-containing protein. (2271 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (75 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2017 aa) |
| | LOC107093083 | Importin subunit alpha; Belongs to the importin alpha family. (523 aa) |
| | sumo1 | Small ubiquitin-related modifier. (76 aa) |
| | polk | Polymerase (DNA directed) kappa. (905 aa) |
| | LOC107092444 | Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa) |
| | ppp5c | Serine/threonine-protein phosphatase. (513 aa) |
| | ENSCVAP00000008191 | Reverse transcriptase domain-containing protein. (509 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1026 aa) |
| | LOC107096192 | Small ubiquitin-related modifier. (94 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (529 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1349 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | LOC107087147 | Small ubiquitin-related modifier. (94 aa) |
| | ENSCVAP00000003314 | Histone H2B; Belongs to the histone H2B family. (139 aa) |
| | tmem182 | Transmembrane protein 182a. (248 aa) |
| | prkdc | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3872 aa) |
| | ENSCVAP00000003420 | BRCT domain-containing protein. (183 aa) |
| | rps27a | Ribosomal protein S27a. (181 aa) |
| | rad51d | RAD51 paralog D. (350 aa) |
| | lig3 | Ligase III, DNA, ATP-dependent. (819 aa) |
| | ENSCVAP00000003888 | Tyrosyl-DNA phosphodiesterase 1. (285 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1456 aa) |
| | LOC107096859 | Histone H2A; Belongs to the histone H2A family. (138 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (615 aa) |
| | sirt6 | Sirtuin 6. (349 aa) |
| | Nhej1 | Nonhomologous end-joining factor 1. (263 aa) |
| | ENSCVAP00000004399 | Uncharacterized protein. (171 aa) |
| | dntt | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (496 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (643 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (877 aa) |
| | ENSCVAP00000005887 | XPGI domain-containing protein. (618 aa) |
| | ENSCVAP00000006422 | Tudor domain containing 3. (116 aa) |
| | ENSCVAP00000006623 | Uncharacterized protein. (209 aa) |
| | ENSCVAP00000006947 | Rad60-SLD domain-containing protein. (58 aa) |
| | LOC107103120 | SLX1 homolog B, structure-specific endonuclease subunit. (218 aa) |
| | LOC107101413 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1035 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | LOC107102680 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (596 aa) |
| | EME2 | ERCC4 domain-containing protein. (448 aa) |
| | ENSCVAP00000000721 | Uncharacterized protein. (212 aa) |
| | timeless | Timeless circadian clock. (1251 aa) |
| | ENSCVAP00000000885 | Rad51 domain-containing protein. (153 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa) |
| | LOC107094607 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | ENSCVAP00000001703 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (85 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | atrip | Uncharacterized protein. (773 aa) |
| | rif1 | Replication timing regulatory factor 1. (2380 aa) |
| | brca1 | Uncharacterized protein. (1314 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa) |
| | ENSCVAP00000031585 | Uncharacterized protein. (85 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | LOC107083399 | Importin subunit alpha; Belongs to the importin alpha family. (519 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (317 aa) |
| | sirt7 | Sirtuin 7. (409 aa) |
| | ENSCVAP00000030894 | Reverse transcriptase domain-containing protein. (142 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2502 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (567 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1325 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | ENSCVAP00000029008 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (671 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (623 aa) |
| | rad51ap1 | RAD51 associated protein 1. (322 aa) |
| | cnppd1 | Cyclin Pas1/PHO80 domain containing 1. (424 aa) |
| | uimc1 | Uncharacterized protein. (990 aa) |
| | ccna1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (389 aa) |
| | ENSCVAP00000027771 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1274 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (507 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa) |
| | apbb1 | Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (682 aa) |
| | ENSCVAP00000026159 | Uncharacterized protein. (289 aa) |
| | ENSCVAP00000025689 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (160 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1358 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1503 aa) |
| | LOC107089962 | Zgc:110269. (342 aa) |
| | recql4 | RecQ helicase-like 4. (942 aa) |
| | lig4 | DNA ligase. (908 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (374 aa) |
| | baz1a | Bromodomain adjacent to zinc finger domain, 1A. (1029 aa) |
| | rfc1 | Replication factor C subunit 1. (1159 aa) |
| | kxd1 | KxDL motif containing 1. (184 aa) |
| | LOC107096065 | Uncharacterized protein. (233 aa) |
| | LOC107103559 | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | LOC107090509 | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (531 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (555 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (351 aa) |
| | ENSCVAP00000022090 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (97 aa) |
| | ENSCVAP00000021767 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (167 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa) |
| | ENSCVAP00000021667 | Ubiquitin-like domain-containing protein. (83 aa) |
| | Ankrd12 | ANK_REP_REGION domain-containing protein. (438 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa) |
| | LOC107087199 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | tdp2 | Tyrosyl-DNA phosphodiesterase 2b. (359 aa) |
| | LOC107096240 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ENSCVAP00000020959 | Histone domain-containing protein; Belongs to the histone H2B family. (155 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6. (624 aa) |
| | nbn | Nibrin. (835 aa) |
| | Gen1 | Chromo_2 domain-containing protein. (523 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (525 aa) |
| | ENSCVAP00000019965 | WGR domain-containing protein. (153 aa) |
| | LOC107083895 | Uncharacterized protein. (400 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | LOC107100955 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSCVAP00000019159 | Methionine sulfoxide reductase B1b. (252 aa) |
| | mdc1 | Uncharacterized protein. (1864 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (373 aa) |
| | ENSCVAP00000019055 | Uncharacterized protein. (256 aa) |
| | abl1 | Tyrosine-protein kinase. (1115 aa) |
| | Slx4 | BTB domain-containing protein. (1002 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (380 aa) |
| | Xrcc4 | Uncharacterized protein. (243 aa) |
| | pold4 | Si:dkey-28b4.7. (107 aa) |
| | rnf169 | Ring finger protein 169. (572 aa) |
| | ENSCVAP00000017348 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | ENSCVAP00000017263 | Histone H2B; Belongs to the histone H2B family. (107 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (424 aa) |
| | polq | Polymerase (DNA directed), theta. (2106 aa) |
| | ENSCVAP00000016466 | Uncharacterized protein. (164 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa) |
| | xrcc5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | cdca7 | Cell division cycle associated 7a. (394 aa) |
| | eya4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (642 aa) |
| | LOC107095354 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | ENSCVAP00000015397 | Uncharacterized protein. (86 aa) |
| | XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3. (454 aa) |
| | LOC107103454 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (475 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (608 aa) |
| | ENSCVAP00000014960 | BRCT domain-containing protein. (175 aa) |
| | baz1b | Bromodomain adjacent to zinc finger domain, 1B. (1579 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (508 aa) |
| | LOC107101698 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | LOC107099910 | BLM RecQ like helicase. (1091 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (493 aa) |
| | rhno1 | Si:ch73-352p4.5. (287 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (426 aa) |
| | Polh | Polymerase (DNA directed), eta. (298 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2823 aa) |
| | LOC107082497 | Tudor domain containing 3. (759 aa) |
| | ENSCVAP00000012726 | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (522 aa) |
| | CDCA7L | zf-4CXXC_R1 domain-containing protein. (405 aa) |
| | Atm | Uncharacterized protein. (145 aa) |
| | ENSCVAP00000011755 | TAN domain-containing protein. (119 aa) |
| | LOC107093321 | Lysine (K)-specific demethylase 4B. (1222 aa) |
