STRINGSTRING
slf1 slf1 rmi1 rmi1 sirt6 sirt6 LOC107096859 LOC107096859 nsd2 nsd2 rad51d rad51d rps27a rps27a ENSCVAP00000003314 ENSCVAP00000003314 LOC107087147 LOC107087147 pcna pcna tp53bp1 tp53bp1 pole2 pole2 babam2 babam2 LOC107096192 LOC107096192 atrip atrip sumo2 sumo2 ENSCVAP00000001703 ENSCVAP00000001703 LOC107094607 LOC107094607 chek1 chek1 cdk2 cdk2 ENSCVAP00000000885 ENSCVAP00000000885 timeless timeless ENSCVAP00000000721 ENSCVAP00000000721 EME2 EME2 rpa3 rpa3 babam1 babam1 Slx4 Slx4 abl1 abl1 ENSCVAP00000019055 ENSCVAP00000019055 rfc2 rfc2 pold4 pold4 mdc1 mdc1 ENSCVAP00000019159 ENSCVAP00000019159 ube2i ube2i LOC107100955 LOC107100955 pole3 pole3 LOC107083895 LOC107083895 Gen1 Gen1 nbn nbn ENSCVAP00000020959 ENSCVAP00000020959 LOC107096240 LOC107096240 LOC107087199 LOC107087199 rnf8 rnf8 Ankrd12 Ankrd12 ENSCVAP00000021667 ENSCVAP00000021667 pold2 pold2 ENSCVAP00000021767 ENSCVAP00000021767 ENSCVAP00000022090 ENSCVAP00000022090 RCBTB1 RCBTB1 pold1 pold1 LOC107103559 LOC107103559 kxd1 kxd1 rfc1 rfc1 rad52 rad52 recql4 recql4 topbp1 topbp1 hus1 hus1 dna2 dna2 uba52 uba52 ENSCVAP00000025689 ENSCVAP00000025689 kat5 kat5 ccna2 ccna2 tipin tipin rfc3 rfc3 rad50 rad50 ENSCVAP00000027771 ENSCVAP00000027771 ccna1 ccna1 uimc1 uimc1 rad51ap1 rad51ap1 exd2 exd2 ENSCVAP00000029008 ENSCVAP00000029008 rad1 rad1 mre11 mre11 rad51 rad51 rfc5 rfc5 palb2 palb2 atr atr ENSCVAP00000030894 ENSCVAP00000030894 sirt7 sirt7 abraxas1 abraxas1 ppp4c ppp4c rad9a rad9a ENSCVAP00000031585 ENSCVAP00000031585 rnf169 rnf169 brca1 brca1 ENSCVAP00000017348 ENSCVAP00000017348 ENSCVAP00000017263 ENSCVAP00000017263 rfc4 rfc4 ppp4r2 ppp4r2 ENSCVAP00000016466 ENSCVAP00000016466 rpa1 rpa1 pole4 pole4 cdca7 cdca7 LOC107095354 LOC107095354 ENSCVAP00000015397 ENSCVAP00000015397 XRCC3 XRCC3 mus81 mus81 pias4 pias4 LOC107101698 LOC107101698 LOC107099910 LOC107099910 rpa2 rpa2 rad17 rad17 rhno1 rhno1 rnf168 rnf168 Polh Polh rmi2 rmi2 ankrd11 ankrd11 LOC107082497 LOC107082497 ENSCVAP00000012726 ENSCVAP00000012726 eme1 eme1 CDCA7L CDCA7L Atm Atm ENSCVAP00000011755 ENSCVAP00000011755 LOC107088102 LOC107088102 LOC107090503 LOC107090503 ENSCVAP00000010146 ENSCVAP00000010146 Rbbp8 Rbbp8 pole pole polk polk LOC107092444 LOC107092444 ENSCVAP00000008191 ENSCVAP00000008191 top3a top3a LOC107103120 LOC107103120 ENSCVAP00000006947 ENSCVAP00000006947 ENSCVAP00000006623 ENSCVAP00000006623 ENSCVAP00000006422 ENSCVAP00000006422 ENSCVAP00000005887 ENSCVAP00000005887
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
slf1SMC5-SMC6 complex localization factor 1. (877 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (643 aa)
sirt6Sirtuin 6. (349 aa)
LOC107096859Histone H2A; Belongs to the histone H2A family. (138 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1456 aa)
rad51dRAD51 paralog D. (350 aa)
rps27aRibosomal protein S27a. (181 aa)
ENSCVAP00000003314Histone H2B; Belongs to the histone H2B family. (139 aa)
LOC107087147Small ubiquitin-related modifier. (94 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1349 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (529 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
LOC107096192Small ubiquitin-related modifier. (94 aa)
atripUncharacterized protein. (773 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
ENSCVAP00000001703Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (85 aa)
LOC107094607UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ENSCVAP00000000885Rad51 domain-containing protein. (153 aa)
timelessTimeless circadian clock. (1251 aa)
ENSCVAP00000000721Uncharacterized protein. (212 aa)
EME2ERCC4 domain-containing protein. (448 aa)
rpa3Replication protein A3. (122 aa)
babam1BRISC and BRCA1 A complex member 1. (380 aa)
Slx4BTB domain-containing protein. (1002 aa)
abl1Tyrosine-protein kinase. (1115 aa)
ENSCVAP00000019055Uncharacterized protein. (256 aa)
rfc2Replication factor C (activator 1) 2. (373 aa)
pold4Si:dkey-28b4.7. (107 aa)
mdc1Uncharacterized protein. (1864 aa)
ENSCVAP00000019159Methionine sulfoxide reductase B1b. (252 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
LOC107100955Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
LOC107083895Uncharacterized protein. (400 aa)
Gen1Chromo_2 domain-containing protein. (523 aa)
nbnNibrin. (835 aa)
ENSCVAP00000020959Histone domain-containing protein; Belongs to the histone H2B family. (155 aa)
LOC107096240Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC107087199UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
Ankrd12ANK_REP_REGION domain-containing protein. (438 aa)
ENSCVAP00000021667Ubiquitin-like domain-containing protein. (83 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
ENSCVAP00000021767Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (167 aa)
ENSCVAP00000022090Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (97 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (555 aa)
pold1DNA polymerase. (1105 aa)
LOC107103559Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
kxd1KxDL motif containing 1. (184 aa)
rfc1Replication factor C subunit 1. (1159 aa)
rad52RAD52 homolog, DNA repair protein. (374 aa)
recql4RecQ helicase-like 4. (942 aa)
topbp1DNA topoisomerase II binding protein 1. (1503 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
dna2DNA replication helicase/nuclease 2. (1358 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
ENSCVAP00000025689Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (160 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (507 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rad50RAD50 homolog, double strand break repair protein. (1274 aa)
ENSCVAP00000027771Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
ccna1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (389 aa)
uimc1Uncharacterized protein. (990 aa)
rad51ap1RAD51 associated protein 1. (322 aa)
exd2Exonuclease 3'-5' domain containing 2. (671 aa)
ENSCVAP00000029008Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
palb2PALB2_WD40 domain-containing protein. (1325 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2502 aa)
ENSCVAP00000030894Reverse transcriptase domain-containing protein. (142 aa)
sirt7Sirtuin 7. (409 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (317 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
ENSCVAP00000031585Uncharacterized protein. (85 aa)
rnf169Ring finger protein 169. (572 aa)
brca1Uncharacterized protein. (1314 aa)
ENSCVAP00000017348Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ENSCVAP00000017263Histone H2B; Belongs to the histone H2B family. (107 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
ppp4r2Protein phosphatase 4, regulatory subunit 2b. (424 aa)
ENSCVAP00000016466Uncharacterized protein. (164 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
cdca7Cell division cycle associated 7a. (394 aa)
LOC107095354Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
ENSCVAP00000015397Uncharacterized protein. (86 aa)
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 3. (454 aa)
mus81MUS81 structure-specific endonuclease subunit. (608 aa)
pias4Protein inhibitor of activated STAT, 4a. (508 aa)
LOC107101698Histone H2B; Belongs to the histone H2B family. (116 aa)
LOC107099910BLM RecQ like helicase. (1091 aa)
rpa2Replication protein A2. (278 aa)
rad17RAD17 checkpoint clamp loader component. (493 aa)
rhno1Si:ch73-352p4.5. (287 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (426 aa)
PolhPolymerase (DNA directed), eta. (298 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
ankrd11Ankyrin repeat domain 11. (2823 aa)
LOC107082497Tudor domain containing 3. (759 aa)
ENSCVAP00000012726Histone H2B; Belongs to the histone H2B family. (115 aa)
eme1Essential meiotic structure-specific endonuclease 1. (522 aa)
CDCA7Lzf-4CXXC_R1 domain-containing protein. (405 aa)
AtmUncharacterized protein. (145 aa)
ENSCVAP00000011755TAN domain-containing protein. (119 aa)
LOC107088102Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
LOC107090503Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSCVAP00000010146Tower domain-containing protein. (2271 aa)
Rbbp8SAE2 domain-containing protein. (75 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2017 aa)
polkPolymerase (DNA directed) kappa. (905 aa)
LOC107092444Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
ENSCVAP00000008191Reverse transcriptase domain-containing protein. (509 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1026 aa)
LOC107103120SLX1 homolog B, structure-specific endonuclease subunit. (218 aa)
ENSCVAP00000006947Rad60-SLD domain-containing protein. (58 aa)
ENSCVAP00000006623Uncharacterized protein. (209 aa)
ENSCVAP00000006422Tudor domain containing 3. (116 aa)
ENSCVAP00000005887XPGI domain-containing protein. (618 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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