26 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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Your Input:
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (653 aa)
	LOC107086058	Lysine methyltransferase 5Aa. (411 aa)
	LOC107092173	SET and MYND domain containing 2a. (435 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (862 aa)
	ENSCVAP00000011755	TAN domain-containing protein. (119 aa)
	Atm	Uncharacterized protein. (145 aa)
	ENSCVAP00000013077	SET domain-containing protein. (176 aa)
	LOC107098659	Euchromatic histone-lysine N-methyltransferase 1a. (770 aa)
	smyd2	Uncharacterized protein. (432 aa)
	LOC107087301	Lysine methyltransferase 5Ab. (345 aa)
	ENSCVAP00000020457	L3MBTL histone methyl-lysine binding protein 1a. (496 aa)
	LOC107092878	E1A binding protein p300 a. (2648 aa)
	ENSCVAP00000021230	Uncharacterized protein. (160 aa)
	setd9	SET domain containing 9. (272 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (351 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (482 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	ttc5	Tetratricopeptide repeat domain 5. (448 aa)
	JMY-2	Junction mediating and regulatory protein, p53 cofactor. (875 aa)
	LOC107101492	L3MBTL histone methyl-lysine binding protein 1b. (831 aa)
	ehmt1	Euchromatic histone-lysine N-methyltransferase 1b. (1279 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ep300	E1A binding protein p300 b. (2766 aa)
	ENSCVAP00000002072	Uncharacterized protein. (262 aa)
	ehmt2	Euchromatic histone-lysine N-methyltransferase 2. (1130 aa)
	ENSCVAP00000002091	Uncharacterized protein. (123 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSCVAP00000011755	ENSCVAP00000011758	ENSCVAP00000011755	Uncharacterized protein.	TAN domain-containing protein.	0.922
Atm	mdm2	ENSCVAP00000011758	ENSCVAP00000023426	Uncharacterized protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.846
Atm	tp53	ENSCVAP00000011758	ENSCVAP00000022398	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.994
Atm	ttc5	ENSCVAP00000011758	ENSCVAP00000023815	Uncharacterized protein.	Tetratricopeptide repeat domain 5.	0.631
ENSCVAP00000002072	tp53	ENSCVAP00000002072	ENSCVAP00000022398	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.612
ENSCVAP00000002091	tp53	ENSCVAP00000002091	ENSCVAP00000022398	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.612
ENSCVAP00000011755	Atm	ENSCVAP00000011755	ENSCVAP00000011758	TAN domain-containing protein.	Uncharacterized protein.	0.922
ENSCVAP00000011755	mdm2	ENSCVAP00000011755	ENSCVAP00000023426	TAN domain-containing protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.846
ENSCVAP00000011755	tp53	ENSCVAP00000011755	ENSCVAP00000022398	TAN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.947
ENSCVAP00000011755	ttc5	ENSCVAP00000011755	ENSCVAP00000023815	TAN domain-containing protein.	Tetratricopeptide repeat domain 5.	0.631
ENSCVAP00000013077	LOC107098659	ENSCVAP00000013077	ENSCVAP00000018720	SET domain-containing protein.	Euchromatic histone-lysine N-methyltransferase 1a.	0.895
ENSCVAP00000013077	tp53	ENSCVAP00000013077	ENSCVAP00000022398	SET domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.609
ENSCVAP00000013077	uba52	ENSCVAP00000013077	ENSCVAP00000025559	SET domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.611
ENSCVAP00000020457	tp53	ENSCVAP00000020457	ENSCVAP00000022398	L3MBTL histone methyl-lysine binding protein 1a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.612
ENSCVAP00000021230	tp53	ENSCVAP00000021230	ENSCVAP00000022398	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.612
JMY	tp53	ENSCVAP00000010824	ENSCVAP00000022398	Junction mediating and regulatory protein, p53 cofactor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.418
JMY	ttc5	ENSCVAP00000010824	ENSCVAP00000023815	Junction mediating and regulatory protein, p53 cofactor.	Tetratricopeptide repeat domain 5.	0.689
JMY-2	LOC107092878	ENSCVAP00000027281	ENSCVAP00000020689	Junction mediating and regulatory protein, p53 cofactor.	E1A binding protein p300 a.	0.823
JMY-2	ep300	ENSCVAP00000027281	ENSCVAP00000025385	Junction mediating and regulatory protein, p53 cofactor.	E1A binding protein p300 b.	0.823
JMY-2	mdm2	ENSCVAP00000027281	ENSCVAP00000023426	Junction mediating and regulatory protein, p53 cofactor.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.401