43 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (343 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1182 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	ENSCVAP00000019147	WD_REPEATS_REGION domain-containing protein. (66 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2406 aa)
	ENSCVAP00000021667	Ubiquitin-like domain-containing protein. (83 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (351 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (482 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (314 aa)
	ENSCVAP00000032381	WD_REPEATS_REGION domain-containing protein. (68 aa)
	LOC107091261	Ring finger protein 34b. (408 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	ENSCVAP00000029198	V-akt murine thymoma viral oncogene homolog 3b. (181 aa)
	LOC107094245	PR domain containing 1b, with ZNF domain. (709 aa)
	ccna1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (389 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	LOC107084657	Serine/threonine-protein phosphatase. (309 aa)
	LOC107099926	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	txndc11	Thioredoxin domain containing 11. (843 aa)
	LOC107095985	Uncharacterized protein. (350 aa)
	LOC107103532	MAPK associated protein 1. (486 aa)
	Atm	Uncharacterized protein. (145 aa)
	ENSCVAP00000011755	TAN domain-containing protein. (119 aa)
	LOC107085894	Serine/threonine-protein phosphatase. (309 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	phf20	PHD finger protein 20, a. (1005 aa)
	usp2	Ubiquitin carboxyl-terminal hydrolase. (396 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (459 aa)
	rps27a	Ribosomal protein S27a. (181 aa)
	LOC107092768	Ring finger protein 34a. (386 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1724 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC107081272	Uncharacterized protein. (781 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
	daxx	Death-domain associated protein. (673 aa)
	LOC107081535	Uncharacterized protein. (110 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (260 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (301 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (844 aa)
	LOC107083482	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (297 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSCVAP00000011755	ENSCVAP00000011758	ENSCVAP00000011755	Uncharacterized protein.	TAN domain-containing protein.	0.922
Atm	ENSCVAP00000021667	ENSCVAP00000011758	ENSCVAP00000021667	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.652
Atm	ccna1	ENSCVAP00000011758	ENSCVAP00000027889	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.621
Atm	ccna2	ENSCVAP00000011758	ENSCVAP00000027321	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.621
Atm	cdk1	ENSCVAP00000011758	ENSCVAP00000018069	Uncharacterized protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.557
Atm	cdk2	ENSCVAP00000011758	ENSCVAP00000000898	Uncharacterized protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.557
Atm	daxx	ENSCVAP00000011758	ENSCVAP00000000354	Uncharacterized protein.	Death-domain associated protein.	0.412
Atm	mdm2	ENSCVAP00000011758	ENSCVAP00000023426	Uncharacterized protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.846
Atm	mdm4	ENSCVAP00000011758	ENSCVAP00000004343	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.784
Atm	mtor	ENSCVAP00000011758	ENSCVAP00000020185	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.559
Atm	rps27a	ENSCVAP00000011758	ENSCVAP00000003612	Uncharacterized protein.	Ribosomal protein S27a.	0.616
Atm	tp53	ENSCVAP00000011758	ENSCVAP00000022398	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.994
ENSCVAP00000011755	Atm	ENSCVAP00000011755	ENSCVAP00000011758	TAN domain-containing protein.	Uncharacterized protein.	0.922
ENSCVAP00000011755	ENSCVAP00000021667	ENSCVAP00000011755	ENSCVAP00000021667	TAN domain-containing protein.	Ubiquitin-like domain-containing protein.	0.652
ENSCVAP00000011755	ccna1	ENSCVAP00000011755	ENSCVAP00000027889	TAN domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.621
ENSCVAP00000011755	ccna2	ENSCVAP00000011755	ENSCVAP00000027321	TAN domain-containing protein.	Cyclin A2; Belongs to the cyclin family.	0.621
ENSCVAP00000011755	cdk1	ENSCVAP00000011755	ENSCVAP00000018069	TAN domain-containing protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.557
ENSCVAP00000011755	cdk2	ENSCVAP00000011755	ENSCVAP00000000898	TAN domain-containing protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.557
ENSCVAP00000011755	daxx	ENSCVAP00000011755	ENSCVAP00000000354	TAN domain-containing protein.	Death-domain associated protein.	0.412
ENSCVAP00000011755	mdm2	ENSCVAP00000011755	ENSCVAP00000023426	TAN domain-containing protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.846