19 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	dna2	DNA replication helicase/nuclease 2. (1358 aa)
	rpa3	Replication protein A3. (122 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	LOC107092444	Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
	LOC107088102	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
	pola1	DNA polymerase. (1420 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa)
	rpa2	Replication protein A2. (278 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	ENSCVAP00000016466	Uncharacterized protein. (164 aa)
	prim2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (505 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	ENSCVAP00000019055	Uncharacterized protein. (256 aa)
	ENSCVAP00000019159	Methionine sulfoxide reductase B1b. (252 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
	pold1	DNA polymerase. (1105 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (604 aa)
	LOC107089962	Zgc:110269. (342 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000016466	ENSCVAP00000019055	ENSCVAP00000016466	ENSCVAP00000019055	Uncharacterized protein.	Uncharacterized protein.	0.775
ENSCVAP00000016466	ENSCVAP00000019159	ENSCVAP00000016466	ENSCVAP00000019159	Uncharacterized protein.	Methionine sulfoxide reductase B1b.	0.775
ENSCVAP00000016466	LOC107088102	ENSCVAP00000016466	ENSCVAP00000011210	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.884
ENSCVAP00000016466	LOC107089962	ENSCVAP00000016466	ENSCVAP00000024388	Uncharacterized protein.	Zgc:110269.	0.652
ENSCVAP00000016466	LOC107092444	ENSCVAP00000016466	ENSCVAP00000008412	Uncharacterized protein.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.488
ENSCVAP00000016466	dna2	ENSCVAP00000016466	ENSCVAP00000025528	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.811
ENSCVAP00000016466	fen1	ENSCVAP00000016466	ENSCVAP00000020740	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.652
ENSCVAP00000016466	pcna	ENSCVAP00000016466	ENSCVAP00000002844	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.860
ENSCVAP00000016466	pola1	ENSCVAP00000016466	ENSCVAP00000011955	Uncharacterized protein.	DNA polymerase.	0.797
ENSCVAP00000016466	pola2	ENSCVAP00000016466	ENSCVAP00000026450	Uncharacterized protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.794
ENSCVAP00000016466	pold1	ENSCVAP00000016466	ENSCVAP00000023009	Uncharacterized protein.	DNA polymerase.	0.685
ENSCVAP00000016466	pold2	ENSCVAP00000016466	ENSCVAP00000021723	Uncharacterized protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.647
ENSCVAP00000016466	prim1	ENSCVAP00000016466	ENSCVAP00000013334	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.852
ENSCVAP00000016466	prim2	ENSCVAP00000016466	ENSCVAP00000017426	Uncharacterized protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.863
ENSCVAP00000016466	rpa1	ENSCVAP00000016466	ENSCVAP00000016427	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.884
ENSCVAP00000016466	rpa3	ENSCVAP00000016466	ENSCVAP00000000333	Uncharacterized protein.	Replication protein A3.	0.931
ENSCVAP00000019055	ENSCVAP00000016466	ENSCVAP00000019055	ENSCVAP00000016466	Uncharacterized protein.	Uncharacterized protein.	0.775
ENSCVAP00000019055	LOC107089962	ENSCVAP00000019055	ENSCVAP00000024388	Uncharacterized protein.	Zgc:110269.	0.596
ENSCVAP00000019055	dna2	ENSCVAP00000019055	ENSCVAP00000025528	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.891
ENSCVAP00000019055	fen1	ENSCVAP00000019055	ENSCVAP00000020740	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.596