22 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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gene fusions

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protein homology

Your Input:
	PMVK	Phosphomevalonate kinase. (198 aa)
	ggps1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (315 aa)
	pcyox1	Prenylcysteine oxidase 1. (507 aa)
	LOC107090374	3-hydroxy-3-methylglutaryl coenzyme A reductase. (861 aa)
	pdss1	Prenyl (decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family. (421 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (783 aa)
	LOC107093655	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (432 aa)
	nus1	NUS1 dehydrodolichyl diphosphate synthase subunit. (322 aa)
	dhdds	Alkyl transferase; Belongs to the UPP synthase family. (335 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	mvd	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (403 aa)
	fnta	Farnesyltransferase, CAAX box, alpha. (370 aa)
	idi1	Isopentenyl-diphosphate delta isomerase 1. (289 aa)
	fdps	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (367 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (438 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
	rce1	Ras converting CAAX endopeptidase 1a. (302 aa)
	pcyox1l	Prenylcysteine oxidase 1 like. (501 aa)
	icmt	Protein-S-isoprenylcysteine O-methyltransferase. (291 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	LOC107102750	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (554 aa)
	pdss2	Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (385 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107090374	LOC107102750	ENSCVAP00000010965	ENSCVAP00000031732	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
LOC107090374	PMVK	ENSCVAP00000010965	ENSCVAP00000001904	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase.	0.490
LOC107090374	acat1	ENSCVAP00000010965	ENSCVAP00000015963	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.410
LOC107090374	acat2	ENSCVAP00000010965	ENSCVAP00000020413	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.410
LOC107090374	dhdds	ENSCVAP00000010965	ENSCVAP00000015328	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Alkyl transferase; Belongs to the UPP synthase family.	0.450
LOC107090374	fdps	ENSCVAP00000010965	ENSCVAP00000019286	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.647
LOC107090374	ggps1	ENSCVAP00000010965	ENSCVAP00000002178	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.633
LOC107090374	hmgcr	ENSCVAP00000010965	ENSCVAP00000014115	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC107090374	idi1	ENSCVAP00000010965	ENSCVAP00000018857	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Isopentenyl-diphosphate delta isomerase 1.	0.733
LOC107090374	mvd	ENSCVAP00000010965	ENSCVAP00000017441	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.503
LOC107090374	mvk	ENSCVAP00000010965	ENSCVAP00000021622	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.995
LOC107090374	nus1	ENSCVAP00000010965	ENSCVAP00000015068	3-hydroxy-3-methylglutaryl coenzyme A reductase.	NUS1 dehydrodolichyl diphosphate synthase subunit.	0.450
LOC107090374	pdss1	ENSCVAP00000010965	ENSCVAP00000014045	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Prenyl (decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family.	0.477
LOC107090374	pdss2	ENSCVAP00000010965	ENSCVAP00000032713	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family.	0.477
LOC107093655	dhdds	ENSCVAP00000014477	ENSCVAP00000015328	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Alkyl transferase; Belongs to the UPP synthase family.	0.945
LOC107093655	fdps	ENSCVAP00000014477	ENSCVAP00000019286	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.939
LOC107093655	fnta	ENSCVAP00000014477	ENSCVAP00000017850	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Farnesyltransferase, CAAX box, alpha.	0.997
LOC107093655	ggps1	ENSCVAP00000014477	ENSCVAP00000002178	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.940
LOC107093655	icmt	ENSCVAP00000014477	ENSCVAP00000031464	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Protein-S-isoprenylcysteine O-methyltransferase.	0.545
LOC107093655	nus1	ENSCVAP00000014477	ENSCVAP00000015068	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	NUS1 dehydrodolichyl diphosphate synthase subunit.	0.935