STRINGSTRING
smug1 smug1 MUTYH MUTYH pole2 pole2 pcna pcna neil3 neil3 ung ung parp2 parp2 LOC107092203 LOC107092203 LOC107092444 LOC107092444 lig1 lig1 pole pole ogg1 ogg1 LOC107092109 LOC107092109 LOC107088138 LOC107088138 polb polb pole4 pole4 pold4 pold4 apex2 apex2 pole3 pole3 LOC107089545 LOC107089545 parp3 parp3 nthl1 nthl1 fen1 fen1 pold2 pold2 pold1 pold1 LOC107089962 LOC107089962 mpg mpg xrcc1 xrcc1 poll poll parp1 parp1 apex1 apex1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smug1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (274 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (527 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (529 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
neil3Nei-like DNA glycosylase 3. (580 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
parp2Poly [ADP-ribose] polymerase. (615 aa)
LOC107092203Thymine DNA glycosylase, tandem duplicate 1. (453 aa)
LOC107092444Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
lig1DNA ligase. (1004 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2017 aa)
ogg18-oxoguanine DNA glycosylase. (390 aa)
LOC107092109High mobility group box 1b. (199 aa)
LOC107088138High mobility group box 1a. (201 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (339 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
pold4Si:dkey-28b4.7. (107 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (572 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
LOC107089545Si:ch211-141o9.10. (326 aa)
parp3Poly [ADP-ribose] polymerase. (525 aa)
nthl1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (313 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
pold1DNA polymerase. (1105 aa)
LOC107089962Zgc:110269. (342 aa)
mpgN-methylpurine DNA glycosylase. (286 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (623 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (567 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (310 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.