42 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpa3	Replication protein A3. (122 aa)
	ercc6	Excision repair cross-complementation group 6. (1441 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (529 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (863 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (612 aa)
	LOC107092444	Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
	lig1	DNA ligase. (1004 aa)
	ercc8	Excision repair cross-complementation group 8. (401 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2017 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
	LOC107088102	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (903 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	LOC107093675	General transcription factor IIH subunit. (392 aa)
	rpa2	Replication protein A2. (278 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	rad23a	RAD23 homolog A, nucleotide excision repair protein a. (351 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	ddb1	Damage-specific DNA binding protein 1. (1080 aa)
	ercc1	Excision repair cross-complementation group 1. (351 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (321 aa)
	rfc2	Replication factor C (activator 1) 2. (373 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (430 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa)
	pold1	DNA polymerase. (1105 aa)
	ercc4	Excision repair cross-complementation group 4. (885 aa)
	rfc1	Replication factor C subunit 1. (1159 aa)
	ddb2	Damage-specific DNA binding protein 2. (487 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (538 aa)
	ercc5	Excision repair cross-complementation group 5. (1006 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	rad23b	RAD23 homolog B, nucleotide excision repair protein. (383 aa)
	cetn2	Centrin, EF-hand protein, 2. (174 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107088102	LOC107092444	ENSCVAP00000011210	ENSCVAP00000008412	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.491
LOC107088102	cetn2	ENSCVAP00000011210	ENSCVAP00000032014	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Centrin, EF-hand protein, 2.	0.471
LOC107088102	cul4a	ENSCVAP00000011210	ENSCVAP00000007408	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cullin 4A; Belongs to the cullin family.	0.456
LOC107088102	cul4b	ENSCVAP00000011210	ENSCVAP00000003895	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cullin 4B; Belongs to the cullin family.	0.456
LOC107088102	ddb1	ENSCVAP00000011210	ENSCVAP00000016510	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Damage-specific DNA binding protein 1.	0.590
LOC107088102	ddb2	ENSCVAP00000011210	ENSCVAP00000024028	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Damage-specific DNA binding protein 2.	0.718
LOC107088102	ercc1	ENSCVAP00000011210	ENSCVAP00000016561	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Excision repair cross-complementation group 1.	0.748
LOC107088102	ercc3	ENSCVAP00000011210	ENSCVAP00000012708	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Excision repair cross-complementation group 3.	0.629
LOC107088102	ercc4	ENSCVAP00000011210	ENSCVAP00000023074	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Excision repair cross-complementation group 4.	0.932
LOC107088102	ercc5	ENSCVAP00000011210	ENSCVAP00000027475	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Excision repair cross-complementation group 5.	0.664
LOC107088102	gtf2h1	ENSCVAP00000011210	ENSCVAP00000027054	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	General transcription factor IIH, polypeptide 1.	0.615
LOC107088102	gtf2h5	ENSCVAP00000011210	ENSCVAP00000020325	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	General transcription factor IIH, polypeptide 5.	0.620
LOC107088102	lig1	ENSCVAP00000011210	ENSCVAP00000008932	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA ligase.	0.729
LOC107088102	pcna	ENSCVAP00000011210	ENSCVAP00000002844	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.923
LOC107088102	pold1	ENSCVAP00000011210	ENSCVAP00000023009	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase.	0.836
LOC107088102	pold2	ENSCVAP00000011210	ENSCVAP00000021723	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.638
LOC107088102	pole	ENSCVAP00000011210	ENSCVAP00000009733	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.765
LOC107088102	pole2	ENSCVAP00000011210	ENSCVAP00000002721	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.707
LOC107088102	pole3	ENSCVAP00000011210	ENSCVAP00000019519	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.574
LOC107088102	pole4	ENSCVAP00000011210	ENSCVAP00000016028	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.527