91 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107093432	Myelocytomatosis oncogene homolog. (361 aa)
	erbb3	Protein kinase domain-containing protein. (1395 aa)
	LOC107092854	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
	LOC107104990	A-Raf proto-oncogene, serine/threonine kinase. (584 aa)
	gab1	GRB2-associated binding protein 1. (766 aa)
	map2k4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	mapk8	Mitogen-activated protein kinase. (470 aa)
	nck2	Cytoplasmic protein. (395 aa)
	LOC107100308	Protein kinase C. (776 aa)
	LOC107101533	Mitogen-activated protein kinase. (429 aa)
	erbb2	Receptor protein-tyrosine kinase. (1289 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
	LOC107095138	Zgc:55558. (187 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1325 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC107087640	Signal transducer and activator of transcription. (785 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (426 aa)
	LOC107101915	Transforming growth factor, alpha. (242 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1310 aa)
	LOC107089901	Protein kinase domain-containing protein. (544 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1004 aa)
	ereg	EGF-like domain-containing protein. (151 aa)
	pak6	Non-specific serine/threonine protein kinase. (697 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC107083639	Uncharacterized protein. (471 aa)
	Jun	BZIP domain-containing protein; Belongs to the bZIP family. (310 aa)
	LOC107092166	Erb-b2 receptor tyrosine kinase 3b. (1435 aa)
	crk	CRK proto-oncogene, adaptor protein. (310 aa)
	LOC107096319	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (498 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (425 aa)
	LOC107086019	Heparin-binding EGF-like growth factor a. (237 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	LOC107087452	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (727 aa)
	pak2	Non-specific serine/threonine protein kinase. (528 aa)
	LOC107101186	Mitogen-activated protein kinase. (379 aa)
	LOC107098202	Uncharacterized protein. (860 aa)
	LOC107086424	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	Nrg4	Uncharacterized protein. (66 aa)
	mapk10	Mitogen-activated protein kinase. (425 aa)
	bad	BCL2 associated agonist of cell death b. (163 aa)
	LOC107099926	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	nck1	Cytoplasmic protein. (394 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	LOC107099902	Uncharacterized protein. (471 aa)
	mapk1	Mitogen-activated protein kinase. (351 aa)
	LOC107083482	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	LOC107092514	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	LOC107103396	Calcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (470 aa)
	LOC107102211	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	pak4	Non-specific serine/threonine protein kinase. (660 aa)
	LOC107102162	BHLH domain-containing protein. (368 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	abl1	Tyrosine-protein kinase. (1115 aa)
	PAK3	Non-specific serine/threonine protein kinase. (554 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2406 aa)
	LOC107096251	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	btc	EGF-like domain-containing protein. (176 aa)
	LOC107089396	PH domain-containing protein. (761 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (952 aa)
	cdkn1b	Cyclin-dependent kinase inhibitor 1Bb. (202 aa)
	LOC107081852	Uncharacterized protein. (318 aa)
	pak1	Non-specific serine/threonine protein kinase. (563 aa)
	LOC107097814	Uncharacterized protein. (718 aa)
	LOC107103682	Uncharacterized protein. (119 aa)
	LOC107099560	Uncharacterized protein. (164 aa)
	ENSCVAP00000026587	Protein kinase domain-containing protein. (186 aa)
	LOC107098892	Receptor protein-tyrosine kinase. (1168 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (308 aa)
	areg	EGF-like domain-containing protein. (232 aa)
	LOC107090959	Eukaryotic translation initiation factor 4E binding protein 1. (121 aa)
	LOC107103577	CaMKII_AD domain-containing protein. (270 aa)
	pak5	Non-specific serine/threonine protein kinase. (757 aa)
	LOC107097013	ETS transcription factor ELK1. (547 aa)
	ENSCVAP00000028872	EGF-like domain-containing protein. (83 aa)
	ENSCVAP00000029198	V-akt murine thymoma viral oncogene homolog 3b. (181 aa)
	LOC107083024	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1306 aa)
	SHC3	SHC adaptor protein 3. (664 aa)
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	PAK6	Non-specific serine/threonine protein kinase. (609 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (715 aa)
	LOC107102050	Mitogen-activated protein kinase. (420 aa)
	LOC107090144	Neuregulin 2b. (696 aa)
	egfr	Receptor protein-tyrosine kinase. (1205 aa)
	LOC107089041	Calcium/calmodulin dependent protein kinase II gamma. (729 aa)
	abl2	Tyrosine-protein kinase. (1189 aa)
	LOC107091800	Signal transducer and activator of transcription. (787 aa)
	LOC107085617	Cyclin-dependent kinase inhibitor 1A. (168 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000026587	LOC107083024	ENSCVAP00000026587	ENSCVAP00000029330	Protein kinase domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.902
ENSCVAP00000026587	LOC107103577	ENSCVAP00000026587	ENSCVAP00000027167	Protein kinase domain-containing protein.	CaMKII_AD domain-containing protein.	0.735
ENSCVAP00000026587	plcg1	ENSCVAP00000026587	ENSCVAP00000008343	Protein kinase domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.902
ENSCVAP00000029198	LOC107083639	ENSCVAP00000029198	ENSCVAP00000011337	V-akt murine thymoma viral oncogene homolog 3b.	Uncharacterized protein.	0.814
ENSCVAP00000029198	LOC107085617	ENSCVAP00000029198	ENSCVAP00000032918	V-akt murine thymoma viral oncogene homolog 3b.	Cyclin-dependent kinase inhibitor 1A.	0.952
ENSCVAP00000029198	LOC107087452	ENSCVAP00000029198	ENSCVAP00000012044	V-akt murine thymoma viral oncogene homolog 3b.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.597
ENSCVAP00000029198	LOC107092854	ENSCVAP00000029198	ENSCVAP00000001486	V-akt murine thymoma viral oncogene homolog 3b.	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	0.814
ENSCVAP00000029198	LOC107096251	ENSCVAP00000029198	ENSCVAP00000020745	V-akt murine thymoma viral oncogene homolog 3b.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.914
ENSCVAP00000029198	LOC107096319	ENSCVAP00000029198	ENSCVAP00000011589	V-akt murine thymoma viral oncogene homolog 3b.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.595
ENSCVAP00000029198	LOC107097814	ENSCVAP00000029198	ENSCVAP00000024831	V-akt murine thymoma viral oncogene homolog 3b.	Uncharacterized protein.	0.814
ENSCVAP00000029198	LOC107099560	ENSCVAP00000029198	ENSCVAP00000026395	V-akt murine thymoma viral oncogene homolog 3b.	Uncharacterized protein.	0.952
ENSCVAP00000029198	LOC107099902	ENSCVAP00000029198	ENSCVAP00000014970	V-akt murine thymoma viral oncogene homolog 3b.	Uncharacterized protein.	0.814
ENSCVAP00000029198	LOC107101186	ENSCVAP00000029198	ENSCVAP00000013006	V-akt murine thymoma viral oncogene homolog 3b.	Mitogen-activated protein kinase.	0.924
ENSCVAP00000029198	LOC107102211	ENSCVAP00000029198	ENSCVAP00000016437	V-akt murine thymoma viral oncogene homolog 3b.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.832
ENSCVAP00000029198	bad	ENSCVAP00000029198	ENSCVAP00000013873	V-akt murine thymoma viral oncogene homolog 3b.	BCL2 associated agonist of cell death b.	0.957
ENSCVAP00000029198	cdkn1b	ENSCVAP00000029198	ENSCVAP00000024118	V-akt murine thymoma viral oncogene homolog 3b.	Cyclin-dependent kinase inhibitor 1Bb.	0.952
ENSCVAP00000029198	gsk3b	ENSCVAP00000029198	ENSCVAP00000011710	V-akt murine thymoma viral oncogene homolog 3b.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.965
ENSCVAP00000029198	map2k4	ENSCVAP00000029198	ENSCVAP00000002373	V-akt murine thymoma viral oncogene homolog 3b.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.914
ENSCVAP00000029198	mapk1	ENSCVAP00000029198	ENSCVAP00000015363	V-akt murine thymoma viral oncogene homolog 3b.	Mitogen-activated protein kinase.	0.924
ENSCVAP00000029198	mtor	ENSCVAP00000029198	ENSCVAP00000020185	V-akt murine thymoma viral oncogene homolog 3b.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.977