STRINGSTRING
Itpr3 Itpr3 smad2 smad2 LOC107090628 LOC107090628 LOC107091148 LOC107091148 prkacb prkacb ccnd1 ccnd1 GNG5 GNG5 HDAC4 HDAC4 GNG4 GNG4 LOC107090582 LOC107090582 ENSCVAP00000002855 ENSCVAP00000002855 gabarap gabarap prkaa2 prkaa2 LOC107096879 LOC107096879 ENSCVAP00000003402 ENSCVAP00000003402 LOC107086118 LOC107086118 PRKAB2 PRKAB2 apln apln prkce prkce LOC107095138 LOC107095138 map2k1 map2k1 KRAS KRAS LOC107084459 LOC107084459 prkaa1 prkaa1 LOC107090039 LOC107090039 LOC107091035 LOC107091035 LOC107090031 LOC107090031 LOC107104314 LOC107104314 slc8a1 slc8a1 mras mras pik3cg pik3cg hras hras LOC107093044 LOC107093044 tfam tfam LOC107102520 LOC107102520 gng3 gng3 LOC107095545 LOC107095545 LOC107098647 LOC107098647 ENSCVAP00000008323 ENSCVAP00000008323 LOC107081039 LOC107081039 serpine1 serpine1 LOC107100676 LOC107100676 nrf1 nrf1 rps6 rps6 calm1 calm1 ENSCVAP00000010568 ENSCVAP00000010568 LOC107083079 LOC107083079 PLCB2 PLCB2 akt1 akt1 LOC107096319 LOC107096319 LOC107089817 LOC107089817 LOC107087452 LOC107087452 LOC107085869 LOC107085869 Lipe Lipe LOC107101186 LOC107101186 LOC107098778 LOC107098778 plcb3 plcb3 LOC107084154 LOC107084154 LOC107094242 LOC107094242 LOC107099926 LOC107099926 agtr1 agtr1 LOC107083005 LOC107083005 map2k2 map2k2 ENSCVAP00000015230 ENSCVAP00000015230 mapk1 mapk1 myl3 myl3 RYR3 RYR3 LOC107101124 LOC107101124 plat plat LOC107083482 LOC107083482 egr1 egr1 adcy7 adcy7 calml4 calml4 ccn2 ccn2 becn1 becn1 LOC107088450 LOC107088450 LOC107092411 LOC107092411 LOC107083431 LOC107083431 LOC107083377 LOC107083377 gnb3 gnb3 LOC107088987 LOC107088987 LOC107093417 LOC107093417 LOC107082238 LOC107082238 LOC107097425 LOC107097425 prkag1 prkag1 mtor mtor ENSCVAP00000020262 ENSCVAP00000020262 LOC107105117 LOC107105117 mef2a mef2a LOC107097276 LOC107097276 ADCY9 ADCY9 LOC107100329 LOC107100329 LOC107102052 LOC107102052 ENSCVAP00000022050 ENSCVAP00000022050 gabarapl2 gabarapl2 gng10 gng10 pde3b pde3b pik3r6 pik3r6 LOC107095164 LOC107095164 LOC107095655 LOC107095655 LOC107091056 LOC107091056 LOC107092670 LOC107092670 itpr2 itpr2 LOC107089355 LOC107089355 gnb4 gnb4 smad3 smad3 LOC107097831 LOC107097831 Ryr2 Ryr2 prkaca prkaca sphk2 sphk2 LOC107097806 LOC107097806 SMAD3 SMAD3 LOC107097118 LOC107097118 ENSCVAP00000025068 ENSCVAP00000025068 LOC107104408 LOC107104408 hdac5 hdac5 LOC107089230 LOC107089230 klf2 klf2 LOC107103619 LOC107103619 gnb1 gnb1 LOC107091525 LOC107091525 PLCB1 PLCB1 gng7 gng7 LOC107087493 LOC107087493 gng8 gng8 pik3c3 pik3c3 LOC107088081 LOC107088081 LOC107093725 LOC107093725 LOC107086436 LOC107086436 ppargc1a ppargc1a LOC107094831 LOC107094831 LOC107091425 LOC107091425 ENSCVAP00000029198 ENSCVAP00000029198 LOC107093673 LOC107093673 LOC107093662 LOC107093662 SLC9A1 SLC9A1 ENSCVAP00000030040 ENSCVAP00000030040 nos1 nos1 LOC107082357 LOC107082357 gnb2 gnb2 LOC107097492 LOC107097492 LOC107082888 LOC107082888 LOC107081729 LOC107081729 mef2c mef2c adcy2 adcy2 adcy5 adcy5 LOC107088982 LOC107088982
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Itpr3Ion_trans domain-containing protein. (468 aa)
smad2Mothers against decapentaplegic homolog. (474 aa)
LOC107090628Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (762 aa)
LOC107091148Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1098 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC107090582MADS-box domain-containing protein. (464 aa)
ENSCVAP00000002855MNNL domain-containing protein. (150 aa)
gabarapGABA(A) receptor-associated protein b. (122 aa)
prkaa2Non-specific serine/threonine protein kinase. (557 aa)
LOC107096879Guanine nucleotide binding protein (G protein), beta 5a. (329 aa)
ENSCVAP00000003402Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LOC107086118Guanine nucleotide binding protein (G protein), beta polypeptide 3b. (342 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (267 aa)
aplnUncharacterized protein. (74 aa)
prkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (554 aa)
LOC107095138Zgc:55558. (187 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
LOC107084459Mothers against decapentaplegic homolog. (516 aa)
prkaa1Non-specific serine/threonine protein kinase. (564 aa)
LOC107090039Myosin light chain kinase family, member 4a. (810 aa)
LOC107091035Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1107 aa)
LOC107090031Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
LOC107104314Uncharacterized protein. (354 aa)
slc8a1Solute carrier family 8 member 1b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (949 aa)
mrasMuscle RAS oncogene homolog. (208 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1120 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
LOC107093044Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
tfamTranscription factor A, mitochondrial. (253 aa)
LOC107102520Uncharacterized protein. (413 aa)
gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC107095545Myosin, light chain kinase a. (733 aa)
LOC107098647Phosphoinositide phospholipase C. (814 aa)
ENSCVAP00000008323Cardiac myosin light chain-1. (200 aa)
LOC107081039Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (538 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (435 aa)
LOC107100676Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
nrf1Nuclear respiratory factor 1. (498 aa)
rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
calm1Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
ENSCVAP00000010568Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (391 aa)
LOC107083079Notch receptor 3. (2466 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
LOC107096319Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (498 aa)
LOC107089817Ryanodine receptor 1a (skeletal). (3848 aa)
LOC107087452Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
LOC107085869Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LipeLipase, hormone-sensitive b. (835 aa)
LOC107101186Mitogen-activated protein kinase. (379 aa)
LOC107098778Mothers against decapentaplegic homolog. (466 aa)
plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1221 aa)
LOC107084154Solute carrier family 8 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (956 aa)
LOC107094242GABA type A receptor associated protein like 2. (117 aa)
LOC107099926Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
agtr1Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC107083005Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
ENSCVAP00000015230Uncharacterized protein. (192 aa)
mapk1Mitogen-activated protein kinase. (351 aa)
myl3Myosin, light chain 13. (187 aa)
RYR3Ryanodine receptor 3. (4778 aa)
LOC107101124MADS-box domain-containing protein. (569 aa)
platPlasminogen activator, tissue. (608 aa)
LOC107083482Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1090 aa)
calml4Calmodulin-like 4a. (186 aa)
ccn2Cellular communication network factor 2a. (346 aa)
becn1Beclin 1, autophagy related. (448 aa)
LOC107088450Mothers against decapentaplegic homolog. (503 aa)
LOC107092411Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1153 aa)
LOC107083431Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1450 aa)
LOC107083377Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (543 aa)
gnb3Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (340 aa)
LOC107088987Uncharacterized protein. (357 aa)
LOC107093417Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
LOC107082238Zgc:92606. (117 aa)
LOC107097425Uncharacterized protein. (354 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (334 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2406 aa)
ENSCVAP00000020262MIR domain-containing protein. (209 aa)
LOC107105117Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (303 aa)
mef2aMyocyte enhancer factor 2aa. (528 aa)
LOC107097276Uncharacterized protein. (171 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1424 aa)
LOC107100329Guanine nucleotide binding protein (G protein), alpha 13b. (378 aa)
LOC107102052Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ENSCVAP00000022050CBS domain-containing protein. (115 aa)
gabarapl2GABA(A) receptor-associated protein like 2. (116 aa)
gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
pde3bPhosphodiesterase. (1099 aa)
pik3r6Uncharacterized protein. (490 aa)
LOC107095164Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
LOC107095655Myosin light chain kinase family, member 4b. (693 aa)
LOC107091056AMPKBI domain-containing protein. (269 aa)
LOC107092670Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (356 aa)
itpr2Inositol 1,4,5-trisphosphate receptor, type 2. (2625 aa)
LOC107089355WD_REPEATS_REGION domain-containing protein. (252 aa)
gnb4Guanine nucleotide binding protein (G protein), beta polypeptide 4b. (340 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC107097831Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
Ryr2Ion_trans domain-containing protein. (255 aa)
prkacaUncharacterized protein; Belongs to the protein kinase superfamily. (382 aa)
sphk2Sphingosine kinase 2. (900 aa)
LOC107097806Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (265 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC107097118Uncharacterized protein. (359 aa)
ENSCVAP00000025068Uncharacterized protein. (1006 aa)
LOC107104408Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1136 aa)
LOC107089230Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
klf2Kruppel-like factor 2b. (383 aa)
LOC107103619Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
gnb1Guanine nucleotide binding protein (G protein), beta polypeptide 1a. (340 aa)
LOC107091525Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC107087493Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
gng8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (885 aa)
LOC107088081DAGKc domain-containing protein. (562 aa)
LOC107093725Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (336 aa)
LOC107086436Guanine nucleotide binding protein (G protein), gamma 13a. (67 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (892 aa)
LOC107094831Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1207 aa)
LOC107091425Solute carrier family 8 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (925 aa)
ENSCVAP00000029198V-akt murine thymoma viral oncogene homolog 3b. (181 aa)
LOC107093673Myosin, light chain 2a, regulatory, cardiac, slow. (169 aa)
LOC107093662Ryanodine receptor 3. (4796 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (804 aa)
ENSCVAP00000030040Solute carrier family 8 member 4a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (593 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1428 aa)
LOC107082357Inositol 1,4,5-trisphosphate receptor, type 1b. (2672 aa)
gnb2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
LOC107097492Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (306 aa)
LOC107082888Uncharacterized protein. (466 aa)
LOC107081729Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
mef2cMyocyte enhancer factor 2cb. (526 aa)
adcy2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1189 aa)
LOC107088982Uncharacterized protein. (354 aa)
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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