(18 nodes) Tetrahydrofolate interconversion, and Glycine catabolic process network (Ectocarpus siliculosus)

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Your Input:
	Esi_0018_0204	DAO domain-containing protein. (389 aa)
	Esi_0203_0046	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (256 aa)
	Esi_0221_0023	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1000 aa)
	Esi_0305_0037	Putative methylene tetrahydrofolate dehydrogenase. (343 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (170 aa)
	Esi_0046_0033	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (419 aa)
	ThiO	Glycine oxidase ThiO. (866 aa)
	Esi_0000_0340	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (581 aa)
	Esi_0116_0039	Uncharacterized protein. (642 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	Esi_0019_0094	Folate-binding protein YgfZ. (544 aa)
	Esi_0292_0008	Uncharacterized protein. (57 aa)
	FMT	Methionyl-tRNA formyltransferase. (451 aa)
	Esi_0056_0101	Uncharacterized protein. (491 aa)
	Esi_0009_0081	Uncharacterized protein. (292 aa)
	Esi_0009_0170	DAO domain-containing protein. (402 aa)
	Esi_0099_0014	Uncharacterized protein. (517 aa)
	SHMT2-3	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (491 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Esi_0000_0340	Esi_0009_0081	D8LBA4	D8LTP6	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.925
Esi_0000_0340	Esi_0019_0094	D8LBA4	D8LH90	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Folate-binding protein YgfZ.	0.924
Esi_0000_0340	Esi_0046_0033	D8LBA4	D7G1U3	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.924
Esi_0000_0340	Esi_0056_0101	D8LBA4	D8LQ10	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.925
Esi_0000_0340	Esi_0099_0014	D8LBA4	D8LU87	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.925
Esi_0000_0340	Esi_0116_0039	D8LBA4	D8LDA9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.942
Esi_0000_0340	Esi_0203_0046	D8LBA4	D7FQL2	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.573
Esi_0000_0340	Esi_0221_0023	D8LBA4	D7FRW0	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.616
Esi_0000_0340	Esi_0292_0008	D8LBA4	D8LKA5	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.942
Esi_0000_0340	Esi_0305_0037	D8LBA4	D7FWG9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Putative methylene tetrahydrofolate dehydrogenase.	0.925
Esi_0000_0340	FMT	D8LBA4	D8LKZ7	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Methionyl-tRNA formyltransferase.	0.976
Esi_0000_0340	GCSH	D8LBA4	D7G1U2	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.609
Esi_0000_0340	SHMT2	D8LBA4	D8LFD6	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.932
Esi_0000_0340	SHMT2-3	D8LBA4	D8LUA3	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.932
Esi_0000_0340	ThiO	D8LBA4	D7G5B9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Glycine oxidase ThiO.	0.916
Esi_0009_0081	Esi_0000_0340	D8LTP6	D8LBA4	Uncharacterized protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.925
Esi_0009_0081	Esi_0009_0170	D8LTP6	D8LTU1	Uncharacterized protein.	DAO domain-containing protein.	0.564
Esi_0009_0081	Esi_0018_0204	D8LTP6	D7FNS1	Uncharacterized protein.	DAO domain-containing protein.	0.564
Esi_0009_0081	Esi_0019_0094	D8LTP6	D8LH90	Uncharacterized protein.	Folate-binding protein YgfZ.	0.803
Esi_0009_0081	Esi_0046_0033	D8LTP6	D7G1U3	Uncharacterized protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.803