(26 nodes) Glyoxylate metabolism and glycine degradation network (Ectocarpus siliculosus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	Esi_0102_0069	Lipoyl-binding domain-containing protein. (370 aa)
	Esi_0108_0050	Uncharacterized protein. (514 aa)
	Esi_0109_0012	Phosphoribosylpyrophosphate synthetase. (384 aa)
	Pyruvate	Pyruvate dehydrogenase E1 component alpha subunit, mitochondrial (PDHE1-A). (354 aa)
	Esi_0144_0069	Uncharacterized protein. (612 aa)
	OGDC	Oxoglutarate dehydrogenase, N-terminal part. (866 aa)
	OGDC-2	Oxoglutarate dehydrogenase E1 subunit, C-terminal. (114 aa)
	Esi_0163_0048	Dihydrolipoamide S-acetyltransferase. (1262 aa)
	PDH	Pyruvate dehydrogenase E1 component subunit beta. (125 aa)
	Esi_0305_0003	Dihydrolipoamide succinyltransferase. (300 aa)
	Esi_0326_0032	Dihydrolipoamide acetyltransferase. (321 aa)
	Esi_0358_0027	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (623 aa)
	Esi_0358_0029	Branched chain alpha-keto acid dehydrogenase E1 beta subunit. (451 aa)
	Esi_0073_0036	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (409 aa)
	Esi_0098_0083	Mercuric reductase A. (399 aa)
	GCSL	Dihydrolipoyl dehydrogenase. (502 aa)
	PDH-2	Pyruvate dehydrogenase. (806 aa)
	Biotin	Biotin/lipoate A/B protein ligase family. (279 aa)
	PDH-3	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (362 aa)
	TrxR	Thioredoxin reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (773 aa)
	GCSL-2	Dihydrolipoamide dehydrogenase. (544 aa)
	Esi_0322_0031	Dihydrolipoamide acetyltransferase (Partial). (219 aa)
	Esi_0322_0032	Dihydrolipoamide acetyltransferase. (295 aa)
	Esi_0006_0185	Mercuric reductase. (573 aa)
	Esi_0006_0214	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)
	Esi_0009_0090	Lipoyl-binding domain-containing protein. (221 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Biotin	Esi_0006_0185	D8LFX0	D8LQL6	Biotin/lipoate A/B protein ligase family.	Mercuric reductase.	0.736
Biotin	Esi_0006_0214	D8LFX0	D8LQN6	Biotin/lipoate A/B protein ligase family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.874
Biotin	Esi_0009_0090	D8LFX0	D8LTQ3	Biotin/lipoate A/B protein ligase family.	Lipoyl-binding domain-containing protein.	0.802
Biotin	Esi_0073_0036	D8LFX0	D7G687	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.868
Biotin	Esi_0098_0083	D8LFX0	D7G9I3	Biotin/lipoate A/B protein ligase family.	Mercuric reductase A.	0.736
Biotin	Esi_0102_0069	D8LFX0	D7FGX3	Biotin/lipoate A/B protein ligase family.	Lipoyl-binding domain-containing protein.	0.802
Biotin	Esi_0108_0050	D8LFX0	D7FHH4	Biotin/lipoate A/B protein ligase family.	Uncharacterized protein.	0.736
Biotin	Esi_0109_0012	D8LFX0	D7FHK9	Biotin/lipoate A/B protein ligase family.	Phosphoribosylpyrophosphate synthetase.	0.503
Biotin	Esi_0144_0069	D8LFX0	D7FKJ5	Biotin/lipoate A/B protein ligase family.	Uncharacterized protein.	0.736
Biotin	Esi_0163_0048	D8LFX0	D7FM36	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide S-acetyltransferase.	0.802
Biotin	Esi_0305_0003	D8LFX0	D7FWF4	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide succinyltransferase.	0.868
Biotin	Esi_0322_0031	D8LFX0	D8LL61	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide acetyltransferase (Partial).	0.802
Biotin	Esi_0322_0032	D8LFX0	D8LL62	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide acetyltransferase.	0.802
Biotin	Esi_0326_0032	D8LFX0	D7FXE2	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide acetyltransferase.	0.802
Biotin	Esi_0358_0027	D8LFX0	D7FZ94	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.869
Biotin	Esi_0358_0029	D8LFX0	D7FZ95	Biotin/lipoate A/B protein ligase family.	Branched chain alpha-keto acid dehydrogenase E1 beta subunit.	0.862
Biotin	GCSL	D8LFX0	D8LBF4	Biotin/lipoate A/B protein ligase family.	Dihydrolipoyl dehydrogenase.	0.736
Biotin	GCSL-2	D8LFX0	D8LL48	Biotin/lipoate A/B protein ligase family.	Dihydrolipoamide dehydrogenase.	0.736
Biotin	OGDC	D8LFX0	D7FKZ0	Biotin/lipoate A/B protein ligase family.	Oxoglutarate dehydrogenase, N-terminal part.	0.709
Biotin	OGDC-2	D8LFX0	D7FKZ1	Biotin/lipoate A/B protein ligase family.	Oxoglutarate dehydrogenase E1 subunit, C-terminal.	0.709