(14 nodes) Mitochondrial iron-sulfur cluster biogenesis, and NifU-like domain network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	iscA	Iron-sulfur assembly protein. (175 aa)
	Esi_0147_0061	Iron-sulfur cluster assembly protein, similar to nifU. (494 aa)
	Esi_0212_0056	NifU-like protein 2, chloroplast (AtCNfu2) (AtCnfU-V). (276 aa)
	Esi_0217_0021	2Fe-2S ferredoxin-type domain-containing protein. (168 aa)
	Esi_0221_0016	Uncharacterized protein; Belongs to the complex I LYR family. (88 aa)
	Esi_0279_0010	Class-V aminotransferase. (530 aa)
	Esi_0308_0013	Uncharacterized protein. (268 aa)
	Esi_0446_0015	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (149 aa)
	Esi_0089_0014	Uncharacterized protein. (146 aa)
	Esi_0012_0170	2Fe-2S ferredoxin-type domain-containing protein. (199 aa)
	NFS-2	Cysteine desulfurase. (426 aa)
	Esi_0019_0152	Uncharacterized protein. (550 aa)
	Esi_0020_0043	Uncharacterized protein. (261 aa)
	NFS-3	Cysteine desulfurase. (444 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Esi_0012_0170	Esi_0019_0152	D8LDL2	D8LHB2	2Fe-2S ferredoxin-type domain-containing protein.	Uncharacterized protein.	0.414
Esi_0012_0170	Esi_0020_0043	D8LDL2	D8LHT9	2Fe-2S ferredoxin-type domain-containing protein.	Uncharacterized protein.	0.753
Esi_0012_0170	Esi_0089_0014	D8LDL2	D7G8E7	2Fe-2S ferredoxin-type domain-containing protein.	Uncharacterized protein.	0.414
Esi_0012_0170	Esi_0221_0016	D8LDL2	D7FRV6	2Fe-2S ferredoxin-type domain-containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.735
Esi_0012_0170	Esi_0279_0010	D8LDL2	D7FUT4	2Fe-2S ferredoxin-type domain-containing protein.	Class-V aminotransferase.	0.751
Esi_0012_0170	Esi_0308_0013	D8LDL2	D7FWL5	2Fe-2S ferredoxin-type domain-containing protein.	Uncharacterized protein.	0.422
Esi_0012_0170	Esi_0446_0015	D8LDL2	D7G1C2	2Fe-2S ferredoxin-type domain-containing protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.897
Esi_0012_0170	NFS-2	D8LDL2	D8LEU7	2Fe-2S ferredoxin-type domain-containing protein.	Cysteine desulfurase.	0.751
Esi_0012_0170	NFS-3	D8LDL2	D8LSH6	2Fe-2S ferredoxin-type domain-containing protein.	Cysteine desulfurase.	0.751
Esi_0012_0170	iscA	D8LDL2	D7FJK1	2Fe-2S ferredoxin-type domain-containing protein.	Iron-sulfur assembly protein.	0.422
Esi_0019_0152	Esi_0012_0170	D8LHB2	D8LDL2	Uncharacterized protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.414
Esi_0019_0152	Esi_0020_0043	D8LHB2	D8LHT9	Uncharacterized protein.	Uncharacterized protein.	0.421
Esi_0019_0152	Esi_0147_0061	D8LHB2	D7FKR5	Uncharacterized protein.	Iron-sulfur cluster assembly protein, similar to nifU.	0.645
Esi_0019_0152	Esi_0212_0056	D8LHB2	D7FRC2	Uncharacterized protein.	NifU-like protein 2, chloroplast (AtCNfu2) (AtCnfU-V).	0.645
Esi_0019_0152	Esi_0217_0021	D8LHB2	D7FRQ2	Uncharacterized protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.414
Esi_0019_0152	Esi_0279_0010	D8LHB2	D7FUT4	Uncharacterized protein.	Class-V aminotransferase.	0.597
Esi_0019_0152	Esi_0308_0013	D8LHB2	D7FWL5	Uncharacterized protein.	Uncharacterized protein.	0.834
Esi_0019_0152	Esi_0446_0015	D8LHB2	D7G1C2	Uncharacterized protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.842
Esi_0019_0152	NFS-2	D8LHB2	D8LEU7	Uncharacterized protein.	Cysteine desulfurase.	0.597
Esi_0019_0152	NFS-3	D8LHB2	D8LSH6	Uncharacterized protein.	Cysteine desulfurase.	0.597